SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3huu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 ASP A 208
PRO A  38
PHE A 235
SER A 238
ASN A 252
 None
 0.98A 1g60A-3huuA:
2.9		 1g60A-3huuA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		4 / 6 ALA A 130
LEU A 133
ILE A 205
CYH A 177
 None
 1.07A 1sbrA-3huuA:
undetectable
1sbrB-3huuA:
undetectable		 1sbrA-3huuA:
19.68
1sbrB-3huuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		4 / 6 ILE A 180
PRO A 201
LEU A 219
ILE A 204
 None
 1.00A 2q83B-3huuA:
undetectable		 2q83B-3huuA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		4 / 7 THR A 292
VAL A 290
SER A 291
GLU A 288
 None
 1.05A 2v41E-3huuA:
undetectable
2v41F-3huuA:
undetectable		 2v41E-3huuA:
21.36
2v41F-3huuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 LEU A 137
HIS A 142
SER A 202
ILE A 226
SER A 291
 None
 1.30A 2xpwA-3huuA:
0.1		 2xpwA-3huuA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 11 VAL A 110
VAL A 156
TYR A 154
TYR A  89
GLU A 150
 None
 1.14A 3m8pA-3huuA:
0.2
3m8pB-3huuA:
undetectable		 3m8pA-3huuA:
20.83
3m8pB-3huuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 VAL A 110
VAL A 156
TYR A 154
TYR A  89
GLU A 150
 None
 1.13A 3medA-3huuA:
undetectable
3medB-3huuA:
2.2		 3medA-3huuA:
20.97
3medB-3huuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 9 GLY A  84
ILE A 120
GLY A 263
ILE A  47
ILE A 109
 None
 0.98A 3s53A-3huuA:
undetectable		 3s53A-3huuA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 GLY A  84
ILE A 120
GLY A 263
ILE A  47
ILE A 109
 None
 0.99A 3s56A-3huuA:
undetectable		 3s56A-3huuA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 LEU A 137
HIS A 142
SER A 202
ILE A 226
SER A 291
 None
 1.25A 4b3aA-3huuA:
undetectable		 4b3aA-3huuA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		4 / 5 LEU A  88
LEU A 258
LEU A  25
ASN A 124
 None
 1.20A 4n09B-3huuA:
2.7		 4n09B-3huuA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 10 ASP A  94
TYR A  89
ILE A  26
VAL A  73
LEU A  99
 None
 1.43A 5fxfB-3huuA:
undetectable		 5fxfB-3huuA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 9 ILE A  96
LEU A  69
THR A  61
ARG A  59
GLY A  24
 None
 1.26A 5ifuB-3huuA:
2.9		 5ifuB-3huuA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 ILE A  86
ILE A  47
VAL A 110
ASN A 254
ASP A 256
 None
 1.20A 5lg3J-3huuA:
undetectable		 5lg3J-3huuA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN
(Staphylococcus
haemolyticus) 		5 / 12 LEU A  25
GLY A 259
ALA A 262
GLY A 111
ILE A  86
 None
 1.06A 5t2zA-3huuA:
undetectable		 5t2zA-3huuA:
18.01