SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 11 LEU A 326
GLY A 282
PRO A 283
HIS A 289
HIS A 292
 None
TRP  A   1 (-3.7A)
None
None
None
 1.46A 1tmxA-3hv0A:
undetectable		 1tmxA-3hv0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 326
GLY A 282
PRO A 283
HIS A 289
HIS A 292
 None
TRP  A   1 (-3.7A)
None
None
None
 1.32A 1tmxB-3hv0A:
undetectable		 1tmxB-3hv0A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 12 THR A 279
GLY A 280
GLY A 282
GLN A 313
GLN A 401
 TRP  A   1 ( 4.7A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-4.5A)
TRP  A   1 (-3.2A)
 0.95A 2akeA-3hv0A:
48.9		 2akeA-3hv0A:
55.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		10 / 12 TYR A 278
THR A 279
GLY A 280
GLY A 282
THR A 315
GLU A 318
LYS A 319
GLN A 401
GLN A 430
PHE A 434
 TRP  A   1 (-4.2A)
TRP  A   1 ( 4.7A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-4.0A)
TRP  A   1 (-2.5A)
TRP  A   1 (-3.4A)
TRP  A   1 (-3.2A)
TRP  A   1 (-3.4A)
TRP  A   1 (-4.8A)
 0.35A 2akeA-3hv0A:
48.9		 2akeA-3hv0A:
55.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 12 THR A 279
GLY A 280
GLY A 282
GLN A 313
GLN A 401
 TRP  A   1 ( 4.7A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-4.5A)
TRP  A   1 (-3.2A)
 0.93A 2azxA-3hv0A:
47.9		 2azxA-3hv0A:
47.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 12 THR A 279
GLY A 280
GLY A 282
GLN A 401
GLN A 430
 TRP  A   1 ( 4.7A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-3.2A)
TRP  A   1 (-3.4A)
 1.03A 2azxA-3hv0A:
47.9		 2azxA-3hv0A:
47.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		10 / 12 TYR A 278
THR A 279
GLY A 280
GLY A 282
GLN A 313
THR A 315
GLU A 318
GLN A 401
GLN A 430
PHE A 434
 TRP  A   1 (-4.2A)
TRP  A   1 ( 4.7A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-4.5A)
TRP  A   1 (-4.0A)
TRP  A   1 (-2.5A)
TRP  A   1 (-3.2A)
TRP  A   1 (-3.4A)
TRP  A   1 (-4.8A)
 0.30A 2azxA-3hv0A:
47.9		 2azxA-3hv0A:
47.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 12 THR A 279
GLY A 280
GLY A 282
GLN A 313
GLN A 401
 TRP  A   1 ( 4.7A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-4.5A)
TRP  A   1 (-3.2A)
 0.92A 2azxB-3hv0A:
48.0		 2azxB-3hv0A:
47.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 12 THR A 279
GLY A 280
GLY A 282
GLN A 401
GLN A 430
 TRP  A   1 ( 4.7A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-3.2A)
TRP  A   1 (-3.4A)
 1.03A 2azxB-3hv0A:
48.0		 2azxB-3hv0A:
47.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		10 / 12 TYR A 278
THR A 279
GLY A 280
GLY A 282
GLN A 313
THR A 315
GLU A 318
GLN A 401
GLN A 430
PHE A 434
 TRP  A   1 (-4.2A)
TRP  A   1 ( 4.7A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-4.5A)
TRP  A   1 (-4.0A)
TRP  A   1 (-2.5A)
TRP  A   1 (-3.2A)
TRP  A   1 (-3.4A)
TRP  A   1 (-4.8A)
 0.31A 2azxB-3hv0A:
48.0		 2azxB-3hv0A:
47.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		9 / 11 TYR A 278
GLY A 280
GLY A 282
GLN A 313
THR A 315
GLU A 318
GLN A 401
GLN A 430
PHE A 434
 TRP  A   1 (-4.2A)
TRP  A   1 (-3.3A)
TRP  A   1 (-3.7A)
TRP  A   1 (-4.5A)
TRP  A   1 (-4.0A)
TRP  A   1 (-2.5A)
TRP  A   1 (-3.2A)
TRP  A   1 (-3.4A)
TRP  A   1 (-4.8A)
 0.29A 2dr2A-3hv0A:
48.7		 2dr2A-3hv0A:
55.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		4 / 5 ASP A 267
LEU A 266
MET A 239
ARG A 238
 None
 1.42A 2gj5A-3hv0A:
undetectable		 2gj5A-3hv0A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		4 / 8 GLY A 385
PHE A 386
ILE A 375
PHE A 397
 None
 0.68A 3ko0O-3hv0A:
undetectable
3ko0Q-3hv0A:
undetectable		 3ko0O-3hv0A:
14.40
3ko0Q-3hv0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		4 / 8 PHE A 384
GLY A 385
PHE A 386
ILE A 375
 None
 0.92A 3ko0O-3hv0A:
undetectable
3ko0Q-3hv0A:
undetectable		 3ko0O-3hv0A:
14.40
3ko0Q-3hv0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		3 / 3 ASP A 480
ASN A 481
SER A 474
 None
 0.85A 3lslA-3hv0A:
0.6
3lslD-3hv0A:
undetectable		 3lslA-3hv0A:
20.74
3lslD-3hv0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		3 / 3 SER A 474
ASP A 480
ASN A 481
 None
 0.92A 3lslA-3hv0A:
0.7
3lslD-3hv0A:
undetectable		 3lslA-3hv0A:
20.74
3lslD-3hv0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		3 / 3 PHE A 322
GLN A 313
PHE A 386
 None
TRP  A   1 (-4.5A)
None
 0.78A 3rv5A-3hv0A:
undetectable		 3rv5A-3hv0A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT2_A_ASDA1490_1
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 10 GLU A 363
ALA A 403
VAL A 400
TYR A 446
SER A 408
 None
 1.48A 4at2A-3hv0A:
0.0		 4at2A-3hv0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		4 / 6 PHE A 353
LEU A 364
PRO A 404
ARG A 582
 None
 1.30A 4yv5B-3hv0A:
undetectable		 4yv5B-3hv0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		4 / 6 PHE A 353
LEU A 364
PRO A 404
ARG A 582
 None
 1.27A 4yv5A-3hv0A:
undetectable		 4yv5A-3hv0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		3 / 3 VAL A 308
ARG A 260
PRO A 449
 None
 0.60A 5koxA-3hv0A:
undetectable		 5koxA-3hv0A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		4 / 8 VAL A 290
ILE A 485
GLU A 554
LEU A 558
 None
 0.73A 5og9A-3hv0A:
undetectable		 5og9A-3hv0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		4 / 5 HIS A 426
ASP A 431
HIS A 453
ARG A 260
 None
 1.47A 6dchA-3hv0A:
undetectable		 6dchA-3hv0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE
(Cryptosporidium
parvum) 		5 / 12 THR A 305
GLN A 245
THR A 243
LEU A 302
HIS A 248
 None
 1.44A 6exiB-3hv0A:
2.6		 6exiB-3hv0A:
11.31