SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3hva PROTEIN FIMX
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 304
ILE A 425
LEU A 312
 None
 0.56A 2prgA-3hvaA:
undetectable		 2prgA-3hvaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3hva PROTEIN FIMX
(Pseudomonas
aeruginosa) 		4 / 8 MET A 285
PHE A 281
ALA A 351
ALA A 302
 None
 1.01A 3l4dD-3hvaA:
undetectable		 3l4dD-3hvaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3hva PROTEIN FIMX
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 411
HIS A 305
ILE A 349
 None
 0.84A 3u52A-3hvaA:
undetectable
3u52C-3hvaA:
undetectable		 3u52A-3hvaA:
15.98
3u52C-3hvaA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3hva PROTEIN FIMX
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 281
PHE A 345
GLN A 427
ALA A 410
MET A 407
 None
 1.39A 4a84A-3hvaA:
undetectable		 4a84A-3hvaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 3hva PROTEIN FIMX
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 373
LEU A 275
PHE A 336
LEU A 342
ARG A 344
 None
 1.15A 6ew0G-3hvaA:
undetectable		 6ew0G-3hvaA:
20.57