SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		5 / 12 LEU A 271
LEU A 421
MET A 266
LEU A 383
MET A 434
 None
 1.15A 1dtlA-3hvdA:
undetectable		 1dtlA-3hvdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 7 LEU A 500
SER A 327
SER A 329
THR A 331
 None
 0.87A 1dvxA-3hvdA:
undetectable		 1dvxA-3hvdA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 8 GLU A 535
ASP A 546
ILE A 547
THR A 548
 None
 0.92A 1hmyA-3hvdA:
undetectable		 1hmyA-3hvdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		5 / 11 ALA A 604
THR A 702
VAL A 612
ALA A 615
LEU A 498
 None
 0.99A 1jinA-3hvdA:
undetectable		 1jinA-3hvdA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		3 / 3 LEU A 383
LEU A 450
SER A 330
 None
 0.57A 1tlmA-3hvdA:
undetectable		 1tlmA-3hvdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 8 LEU A 187
GLY A 191
LEU A 203
PRO A 254
 None
 0.73A 1ya4A-3hvdA:
undetectable		 1ya4A-3hvdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 7 LEU A 187
GLY A 191
LEU A 203
PRO A 254
 None
 0.65A 1ya4B-3hvdA:
undetectable		 1ya4B-3hvdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 6 LEU A 187
LEU A 203
PRO A 254
VAL A 239
 None
 0.94A 2dqyC-3hvdA:
undetectable		 2dqyC-3hvdA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 8 ILE A 591
PHE A 552
THR A 522
LEU A 583
 None
 0.84A 2einA-3hvdA:
undetectable
2einJ-3hvdA:
undetectable		 2einA-3hvdA:
21.11
2einJ-3hvdA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		5 / 11 THR A 706
THR A 702
ALA A 607
GLY A 641
ALA A 700
 None
 1.20A 2f162-3hvdA:
undetectable		 2f162-3hvdA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		5 / 11 THR A 706
THR A 702
ALA A 607
GLY A 641
ALA A 700
 None
 1.21A 2f16N-3hvdA:
undetectable		 2f16N-3hvdA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 7 PHE A 678
LEU A 627
LEU A 629
GLU A 645
 None
 1.01A 2jn3A-3hvdA:
undetectable		 2jn3A-3hvdA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		5 / 12 ILE A 261
GLY A 370
ALA A 406
ILE A 374
TYR A 233
 None
 1.11A 3jayA-3hvdA:
undetectable		 3jayA-3hvdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 8 SER A 234
PHE A 236
LEU A 187
PRO A 184
 None
 1.23A 3jq7B-3hvdA:
undetectable		 3jq7B-3hvdA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		3 / 3 ASN A 368
ASN A 328
GLU A 502
 None
 0.89A 3kpdC-3hvdA:
undetectable		 3kpdC-3hvdA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 6 ILE A 707
ILE A 676
GLY A 641
VAL A 655
 None
 0.92A 3n3iA-3hvdA:
undetectable		 3n3iA-3hvdA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		5 / 11 LEU A 523
PHE A 552
TYR A 575
LEU A 540
ILE A 547
 None
 1.04A 3o94B-3hvdA:
undetectable		 3o94B-3hvdA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		5 / 12 ALA A 358
LEU A 271
LEU A 442
LEU A 383
ILE A 432
 None
 0.92A 3tq9A-3hvdA:
undetectable		 3tq9A-3hvdA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 7 ILE A 635
LEU A 639
ALA A 615
ALA A 607
 None
 0.65A 4g77A-3hvdA:
undetectable		 4g77A-3hvdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		3 / 3 HIS A 336
TRP A 346
SER A 640
 None
 1.23A 4lrhD-3hvdA:
undetectable		 4lrhD-3hvdA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		3 / 3 ASP A 179
LYS A 518
LEU A 255
 CA  A 736 ( 2.6A)
None
None
 1.06A 4ptjA-3hvdA:
undetectable		 4ptjA-3hvdA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		3 / 3 SER A 296
ASP A 608
ASP A 599
 None
 0.77A 4uckA-3hvdA:
undetectable		 4uckA-3hvdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		5 / 12 GLY A 626
ILE A 665
ILE A 620
ASN A 621
ASN A 630
 None
 1.03A 5fa8A-3hvdA:
undetectable		 5fa8A-3hvdA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 4 THR A 702
LEU A 639
HIS A 616
GLY A 641
 None
 1.25A 5gwyA-3hvdA:
0.0		 5gwyA-3hvdA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		4 / 8 THR A 488
SER A 230
SER A 227
ALA A 258
 None
 1.05A 5l5fY-3hvdA:
undetectable
5l5fZ-3hvdA:
undetectable		 5l5fY-3hvdA:
16.76
5l5fZ-3hvdA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3hvd PROTECTIVE ANTIGEN
(Bacillus
anthracis) 		3 / 3 ALA A 257
GLN A 485
THR A 488
 None
 0.54A 5n0oA-3hvdA:
undetectable		 5n0oA-3hvdA:
20.18