SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hvn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 8 ALA A 401
TRP A 436
TYR A 403
GLY A 397
 None
HTO  A 506 (-4.2A)
None
None
 0.87A 1rukH-3hvnA:
undetectable
1rukL-3hvnA:
undetectable		 1rukH-3hvnA:
19.56
1rukL-3hvnA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 8 SER A 266
SER A 267
SER A 360
GLN A 371
 None
 1.03A 2cmlC-3hvnA:
undetectable		 2cmlC-3hvnA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 8 VAL A 263
LEU A 103
PRO A 114
TYR A 359
 None
 0.96A 2ddwA-3hvnA:
undetectable		 2ddwA-3hvnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 5 PHE A 291
THR A 313
LEU A 338
ALA A 294
 None
 1.34A 2e1qD-3hvnA:
0.7		 2e1qD-3hvnA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 LEU A 102
LEU A 241
LYS A 240
SER A 237
THR A 247
 None
 1.23A 2oipB-3hvnA:
undetectable		 2oipB-3hvnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		3 / 3 LEU A 130
PRO A 131
LEU A 133
 None
 0.47A 2qd5B-3hvnA:
undetectable		 2qd5B-3hvnA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 8 TYR A  98
VAL A 263
LEU A 109
PRO A 114
 None
 1.00A 3jq7C-3hvnA:
undetectable		 3jq7C-3hvnA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 8 SER A 239
GLN A  38
PHE A  37
ASP A  32
 None
 1.27A 3n62A-3hvnA:
undetectable		 3n62A-3hvnA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 GLY A 302
ASN A 303
ALA A 293
ALA A 294
LEU A 310
 None
 0.98A 3p2kC-3hvnA:
undetectable		 3p2kC-3hvnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 8 ILE A 319
ILE A 342
LEU A 338
ILE A 276
 None
 0.94A 4dtaB-3hvnA:
undetectable		 4dtaB-3hvnA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 7 GLY A 255
ILE A 119
LEU A 102
PHE A 242
 None
 0.83A 4ejjD-3hvnA:
undetectable		 4ejjD-3hvnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 LEU A 102
LEU A 241
LYS A 240
SER A 237
THR A 247
 None
 1.11A 4q0dA-3hvnA:
undetectable		 4q0dA-3hvnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 LEU A 102
LEU A 241
LYS A 240
SER A 237
THR A 247
 None
 1.11A 4q0dB-3hvnA:
undetectable		 4q0dB-3hvnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 LEU A 102
LEU A 241
LYS A 240
SER A 237
THR A 247
 None
 1.12A 4q0dC-3hvnA:
undetectable		 4q0dC-3hvnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 LEU A 102
LEU A 241
LYS A 240
SER A 237
THR A 247
 None
 1.11A 4q0dD-3hvnA:
undetectable		 4q0dD-3hvnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 LEU A 102
LEU A 241
LYS A 240
SER A 237
THR A 247
 None
 1.11A 4q0dE-3hvnA:
undetectable		 4q0dE-3hvnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 8 ASN A  34
PRO A 238
PHE A  37
SER A  39
 None
 1.32A 5amiB-3hvnA:
undetectable		 5amiB-3hvnA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 PHE A  37
ILE A 256
PHE A 242
ILE A 117
ALA A 370
 None
 0.84A 5vceA-3hvnA:
undetectable		 5vceA-3hvnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 5 ILE A  90
PHE A 320
ASN A 129
TYR A 270
 None
 1.25A 6a93B-3hvnA:
undetectable		 6a93B-3hvnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 5 ILE A 206
PHE A 208
ASN A 375
TYR A 378
 None
 1.18A 6a93B-3hvnA:
undetectable		 6a93B-3hvnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		5 / 12 LEU A 351
LEU A 158
GLY A 271
GLY A 354
GLY A 325
 None
 1.11A 6ce2B-3hvnA:
undetectable		 6ce2B-3hvnA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3hvn HEMOLYSIN
(Streptococcus
suis) 		4 / 7 GLN A 177
GLY A 321
GLY A 271
VAL A 355
 None
 0.72A 6ekzA-3hvnA:
undetectable		 6ekzA-3hvnA:
10.28