SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3hvs THIOL PEROXIDASE
(Escherichia
coli) 		4 / 8 SER A  64
ILE A  56
PHE A  53
VAL A 135
 CIT  A   1 (-2.8A)
None
None
None
 1.02A 1kb9A-3hvsA:
undetectable
1kb9C-3hvsA:
undetectable
1kb9D-3hvsA:
undetectable
1kb9E-3hvsA:
undetectable		 1kb9A-3hvsA:
19.80
1kb9C-3hvsA:
17.89
1kb9D-3hvsA:
21.60
1kb9E-3hvsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3hvs THIOL PEROXIDASE
(Escherichia
coli) 		4 / 5 ILE A 145
ASN A 143
ILE A 138
ASP A 139
 None
 1.03A 2h4jA-3hvsA:
2.0		 2h4jA-3hvsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3hvs THIOL PEROXIDASE
(Escherichia
coli) 		3 / 3 THR A  29
VAL A  31
GLU A 113
 None
 0.78A 3v4tA-3hvsA:
undetectable
3v4tD-3hvsA:
undetectable		 3v4tA-3hvsA:
19.09
3v4tD-3hvsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3hvs THIOL PEROXIDASE
(Escherichia
coli) 		5 / 11 ALA A  25
GLN A  26
PHE A  28
ALA A 117
VAL A  80
 None
 1.18A 4nqaA-3hvsA:
undetectable		 4nqaA-3hvsA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3hvs THIOL PEROXIDASE
(Escherichia
coli) 		4 / 5 LEU A 127
ALA A 132
LEU A 130
VAL A 150
 None
 1.21A 5cr1A-3hvsA:
undetectable		 5cr1A-3hvsA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3hvs THIOL PEROXIDASE
(Escherichia
coli) 		3 / 3 THR A  73
THR A  78
PHE A  43
 None
 0.89A 5cxvA-3hvsA:
undetectable		 5cxvA-3hvsA:
18.63