SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 4 VAL A 148
THR A 147
VAL A 144
GLY A 145
 None
 1.09A 2p2fB-3hvuA:
5.3		 2p2fB-3hvuA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		6 / 12 ILE A  97
LEU A  60
ALA A  28
ASP A  30
LEU A  52
LEU A  23
 None
 1.27A 2yqzA-3hvuA:
2.9		 2yqzA-3hvuA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		6 / 12 ILE A  97
LEU A  60
ALA A  28
ASP A  30
LEU A  52
LEU A  23
 None
 1.30A 2yqzB-3hvuA:
3.3		 2yqzB-3hvuA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		6 / 12 ILE A  97
LEU A  60
ASP A  30
LEU A  52
LEU A  23
VAL A  20
 None
 1.47A 2yqzB-3hvuA:
3.3		 2yqzB-3hvuA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 6 TYR A 156
VAL A  20
VAL A  98
VAL A 126
 None
 0.96A 2z97A-3hvuA:
undetectable		 2z97A-3hvuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 LEU A 108
GLY A 105
ARG A 135
ILE A 125
ASP A 130
 MES  A 181 (-3.7A)
MES  A 181 (-3.0A)
None
None
None
 1.04A 3gwwA-3hvuA:
undetectable		 3gwwA-3hvuA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 7 VAL A 112
VAL A  67
ILE A  39
ARG A 135
 None
 1.14A 3ms9B-3hvuA:
undetectable		 3ms9B-3hvuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		3 / 3 THR A  88
SER A  89
ARG A  93
 None
 0.53A 3phnA-3hvuA:
undetectable		 3phnA-3hvuA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 9 LEU A  37
ASP A  63
ILE A  82
ILE A  95
ILE A  39
 None
 0.99A 3s56B-3hvuA:
undetectable		 3s56B-3hvuA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 5 LEU A 129
LEU A 158
GLY A 155
GLY A 157
 None
 0.79A 3si7C-3hvuA:
undetectable
3si7D-3hvuA:
undetectable		 3si7C-3hvuA:
20.14
3si7D-3hvuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 7 LEU A  37
ASP A  63
VAL A  67
ILE A  39
 None
 0.81A 3wsjB-3hvuA:
undetectable		 3wsjB-3hvuA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 7 GLY A  40
VAL A  98
PHE A 115
ILE A  95
 None
 0.92A 4fglC-3hvuA:
3.5		 4fglC-3hvuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 7 ILE A  16
LEU A 128
LYS A  43
GLY A  44
 None
 0.99A 4hajA-3hvuA:
undetectable		 4hajA-3hvuA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 8 TYR A 156
VAL A  20
VAL A  98
VAL A 126
 None
 0.99A 4l4bA-3hvuA:
undetectable		 4l4bA-3hvuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 PHE A 146
LEU A 129
ILE A  97
PHE A  48
TYR A 156
 None
 1.49A 5dlvA-3hvuA:
undetectable		 5dlvA-3hvuA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 6 THR A  56
ARG A  55
LEU A  52
ASP A  51
 None
 1.14A 5tdzA-3hvuA:
2.8		 5tdzA-3hvuA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 8 TYR A 156
VAL A  20
VAL A  98
VAL A 126
 None
 0.96A 6cp4A-3hvuA:
undetectable		 6cp4A-3hvuA:
19.22