SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3hvw DIGUANYLATE-CYCLASE
(DGC)
(Pseudomonas
aeruginosa) 		4 / 4 THR A 238
LEU A 250
VAL A 196
LEU A 292
 None
 1.02A 1fbmB-3hvwA:
undetectable		 1fbmB-3hvwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3hvw DIGUANYLATE-CYCLASE
(DGC)
(Pseudomonas
aeruginosa) 		4 / 5 THR A 238
LEU A 250
VAL A 196
LEU A 292
 None
 0.81A 1fbmE-3hvwA:
undetectable		 1fbmE-3hvwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3hvw DIGUANYLATE-CYCLASE
(DGC)
(Pseudomonas
aeruginosa) 		5 / 12 SER A 243
ILE A 242
VAL A 307
ALA A 311
LEU A 201
 None
 1.27A 2japB-3hvwA:
undetectable		 2japB-3hvwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3hvw DIGUANYLATE-CYCLASE
(DGC)
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 267
LEU A 264
SER A 261
THR A 259
 None
 1.10A 4d7bB-3hvwA:
undetectable		 4d7bB-3hvwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3hvw DIGUANYLATE-CYCLASE
(DGC)
(Pseudomonas
aeruginosa) 		5 / 10 ARG A 231
ALA A 269
PHE A 270
GLU A 225
LEU A 239
 None
 1.28A 4la0A-3hvwA:
undetectable		 4la0A-3hvwA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3hvw DIGUANYLATE-CYCLASE
(DGC)
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 267
LEU A 264
SER A 261
THR A 259
 None
 1.06A 5bojA-3hvwA:
undetectable		 5bojA-3hvwA:
20.54