SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hvy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 9 GLY A 233
ILE A 195
ALA A 234
ILE A 237
GLU A 228
 None
 1.17A 1cetA-3hvyA:
4.2		 1cetA-3hvyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ALA A 303
GLY A 247
GLY A 407
LEU A 241
LEU A 293
 None
 1.01A 1eizA-3hvyA:
3.9		 1eizA-3hvyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ALA A 303
GLY A 247
GLY A 407
LEU A 241
LEU A 293
 None
 1.01A 1ej0A-3hvyA:
undetectable		 1ej0A-3hvyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 10 GLY A 239
CYH A 219
LEU A 129
THR A 101
GLY A 105
 None
LLP  A 243 ( 3.5A)
None
LLP  A 243 ( 3.3A)
None
 1.26A 1h4oA-3hvyA:
undetectable
1h4oB-3hvyA:
undetectable		 1h4oA-3hvyA:
17.65
1h4oB-3hvyA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 ILE A 345
LEU A 344
ALA A 311
CYH A 310
 None
 0.67A 1mz9C-3hvyA:
undetectable		 1mz9C-3hvyA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ASN A 244
ILE A 245
ASP A 217
GLY A 239
ALA A 238
 LLP  A 243 ( 4.7A)
None
LLP  A 243 ( 2.9A)
None
None
 1.06A 1r9oA-3hvyA:
undetectable		 1r9oA-3hvyA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 PRO A 297
ILE A 242
GLY A 247
ILE A 245
ASN A 244
 None
LLP  A 243 ( 4.3A)
None
None
LLP  A 243 ( 4.7A)
 1.10A 1sg9A-3hvyA:
4.6		 1sg9A-3hvyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 PHE A  86
VAL A  93
LEU A  78
VAL A  81
GLY A 246
 None
None
None
None
LLP  A 243 ( 4.0A)
 1.04A 2cbrA-3hvyA:
undetectable		 2cbrA-3hvyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 6 PHE A  86
VAL A  93
LEU A  78
ALA A  83
 None
 1.08A 2e1qA-3hvyA:
undetectable		 2e1qA-3hvyA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 7 LEU A 404
PHE A 347
ILE A 313
GLY A 406
 None
 0.84A 2v0mC-3hvyA:
undetectable		 2v0mC-3hvyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 THR A 300
ILE A 388
ALA A 307
GLY A 306
GLY A 407
 None
LLP  A 243 ( 3.8A)
None
None
None
 1.08A 2y7hB-3hvyA:
undetectable		 2y7hB-3hvyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 THR A 300
ILE A 388
ALA A 307
GLY A 306
GLY A 407
 None
LLP  A 243 ( 3.8A)
None
None
None
 1.08A 2y7hC-3hvyA:
undetectable		 2y7hC-3hvyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 10 THR A 101
ILE A 104
GLY A 105
HIS A 180
THR A 128
 LLP  A 243 ( 3.3A)
None
None
None
LLP  A 243 ( 4.8A)
 1.26A 2y7wB-3hvyA:
undetectable		 2y7wB-3hvyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ALA A 303
GLY A 247
GLY A 407
LEU A 241
ALA A 296
 None
 0.90A 3douA-3hvyA:
2.9		 3douA-3hvyA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 4 ILE A 121
GLN A 182
ILE A 202
LEU A 129
 None
LLP  A 243 ( 4.0A)
None
None
 1.29A 3dzyD-3hvyA:
undetectable		 3dzyD-3hvyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		3 / 3 ASN A  99
ASP A 217
GLN A 182
 LLP  A 243 ( 3.3A)
LLP  A 243 ( 2.9A)
LLP  A 243 ( 4.0A)
 0.81A 3eeyC-3hvyA:
5.6		 3eeyC-3hvyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		3 / 3 ASN A  99
ASP A 217
GLN A 182
 LLP  A 243 ( 3.3A)
LLP  A 243 ( 2.9A)
LLP  A 243 ( 4.0A)
 0.83A 3eeyD-3hvyA:
5.5		 3eeyD-3hvyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		3 / 3 ASN A  99
ASP A 217
GLN A 182
 LLP  A 243 ( 3.3A)
LLP  A 243 ( 2.9A)
LLP  A 243 ( 4.0A)
 0.83A 3eeyE-3hvyA:
4.3		 3eeyE-3hvyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 SER A 391
TYR A 220
ALA A 392
GLY A 402
TYR A 187
 None
LLP  A 243 ( 3.6A)
None
None
None
 1.12A 3f8wA-3hvyA:
undetectable		 3f8wA-3hvyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 SER A 391
TYR A 220
ALA A 392
GLY A 402
TYR A 187
 None
LLP  A 243 ( 3.6A)
None
None
None
 1.12A 3f8wC-3hvyA:
undetectable		 3f8wC-3hvyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 GLY A 248
GLY A 246
THR A 409
LEU A 408
SER A 240
 None
LLP  A 243 ( 4.0A)
None
None
LLP  A 243 ( 3.8A)
 1.20A 3mteA-3hvyA:
2.1		 3mteA-3hvyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 9 GLY A 233
ALA A 234
ASP A 235
ILE A 236
ILE A 201
 None
 0.71A 3ogpA-3hvyA:
undetectable		 3ogpA-3hvyA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 9 GLY A 233
ALA A 234
ASP A 235
ILE A 236
ILE A 201
 None
 0.82A 3ogpB-3hvyA:
undetectable		 3ogpB-3hvyA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ASP A 393
GLY A 406
ILE A 388
PRO A 356
VAL A 357
 None
None
LLP  A 243 ( 3.8A)
None
None
 0.95A 3oxcA-3hvyA:
undetectable		 3oxcA-3hvyA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 7 GLY A 233
ALA A 234
ASP A 235
ILE A 201
 None
 0.70A 3t3cA-3hvyA:
undetectable		 3t3cA-3hvyA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 ASP A  72
SER A 281
GLY A 280
ASP A  76
 None
 0.94A 3w9tB-3hvyA:
undetectable		 3w9tB-3hvyA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 ASP A  72
SER A 281
GLY A 280
ASP A  76
 None
 0.94A 3w9tC-3hvyA:
undetectable		 3w9tC-3hvyA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 ASP A  72
SER A 281
GLY A 280
ASP A  76
 None
 0.95A 3w9tD-3hvyA:
undetectable		 3w9tD-3hvyA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		3 / 3 ASP A 217
LEU A 108
VAL A 270
 LLP  A 243 ( 2.9A)
None
None
 0.71A 4jecB-3hvyA:
undetectable		 4jecB-3hvyA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 6 ASP A  79
TYR A  82
LEU A  78
THR A 282
 None
 1.11A 4paeA-3hvyA:
undetectable		 4paeA-3hvyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 6 ILE A 245
GLY A 292
ILE A  57
VAL A  48
 None
 0.81A 4r21A-3hvyA:
1.2		 4r21A-3hvyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ILE A 396
PRO A 395
ALA A 394
ILE A 376
ARG A 397
 None
 1.33A 4uroC-3hvyA:
undetectable		 4uroC-3hvyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ALA A 250
GLU A 222
SER A 240
TYR A  82
LEU A 289
 None
None
LLP  A 243 ( 3.8A)
None
None
 1.47A 4xqeA-3hvyA:
2.8		 4xqeA-3hvyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 11 VAL A 216
ILE A 237
TYR A 255
ILE A 245
ILE A 333
 None
 0.97A 5hw8A-3hvyA:
undetectable
5hw8D-3hvyA:
undetectable		 5hw8A-3hvyA:
15.07
5hw8D-3hvyA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		6 / 12 VAL A 216
ILE A 237
ALA A 238
PHE A  86
GLY A 233
ILE A 202
 None
 1.24A 5j2tC-3hvyA:
2.7		 5j2tC-3hvyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 10 ILE A 181
ILE A 236
ALA A 238
ILE A 237
ILE A 104
 None
 1.02A 5mvmD-3hvyA:
undetectable
5mvmE-3hvyA:
undetectable		 5mvmD-3hvyA:
17.62
5mvmE-3hvyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 7 LEU A 178
ALA A 107
ILE A 132
LEU A 144
 None
 0.86A 5te8C-3hvyA:
0.3		 5te8C-3hvyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 9 LEU A 424
GLY A 416
ILE A 351
PHE A 338
ILE A 336
 None
 1.27A 6ebpA-3hvyA:
undetectable		 6ebpA-3hvyA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 8 TYR A 187
VAL A 375
GLN A 405
ILE A 348
 None
 1.01A 6hzpA-3hvyA:
undetectable		 6hzpA-3hvyA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 7 ASP A 217
TYR A 255
GLU A 222
GLU A 225
 LLP  A 243 ( 2.9A)
None
None
None
 1.32A 6mn5B-3hvyA:
undetectable		 6mn5B-3hvyA:
10.87