SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWX_A_EPAA1_1 (PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)))	3hwj	E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 (Mus musculus)	5 / 10	VAL A1755 ILE A1809 LEU A1771 VAL A1773 LEU A1814	None	1.06A	3gwxA-3hwjA: undetectable	3gwxA-3hwjA: 23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_B_SAMB301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	3hwj	E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 (Mus musculus)	5 / 12	GLY A1840 SER A1729 THR A1728 ASP A1742 ILE A1874	None	1.33A	3iv6B-3hwjA: undetectable	3iv6B-3hwjA: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_B_SAMB301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	3hwj	E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 (Mus musculus)	5 / 12	GLY A1840 SER A1729 THR A1728 ILE A1874 ASP A1808	None	1.06A	3iv6B-3hwjA: undetectable	3iv6B-3hwjA: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NUJ_A_Z80A201_1 (BETA-LACTOGLOBULIN)	3hwj	E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 (Mus musculus)	4 / 8	VAL A1796 PHE A1758 LEU A1771 VAL A1755	None	0.81A	5nujA-3hwjA: undetectable	5nujA-3hwjA: 18.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3GWX_A_EPAA1_1","PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA))","3hwj","E3 UBIQUITIN-PROTEIN LIGASE MYCBP2","Mus musculus",5,"VAL A1755;ILE A1809;LEU A1771;VAL A1773;LEU A1814","None","1.06A","3gwxA-3hwjA:undetectable","3gwxA-3hwjA:23.14"],["3IV6_B_SAMB301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","3hwj","E3 UBIQUITIN-PROTEIN LIGASE MYCBP2","Mus musculus",5,"GLY A1840;SER A1729;THR A1728;ASP A1742;ILE A1874","None","1.33A","3iv6B-3hwjA:undetectable","3iv6B-3hwjA:22.43"],["3IV6_B_SAMB301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","3hwj","E3 UBIQUITIN-PROTEIN LIGASE MYCBP2","Mus musculus",5,"GLY A1840;SER A1729;THR A1728;ILE A1874;ASP A1808","None","1.06A","3iv6B-3hwjA:undetectable","3iv6B-3hwjA:22.43"],["5NUJ_A_Z80A201_1","BETA-LACTOGLOBULIN","3hwj","E3 UBIQUITIN-PROTEIN LIGASE MYCBP2","Mus musculus",4,"VAL A1796;PHE A1758;LEU A1771;VAL A1755","None","0.81A","5nujA-3hwjA:undetectable","5nujA-3hwjA:18.47"]]