SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3hwp PHLG
(Pseudomonas
protegens) 		3 / 3 PHE A 255
LEU A 201
MET A 199
 None
 0.79A 1mx1D-3hwpA:
undetectable		 1mx1D-3hwpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 12 HIS A 129
GLU A 160
HIS A 270
GLU A 274
PHE A 111
 ZN  A 295 (-3.3A)
ZN  A 295 (-2.9A)
ZN  A 295 (-3.3A)
ZN  A 295 (-2.5A)
None
 1.46A 1o86A-3hwpA:
undetectable		 1o86A-3hwpA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3hwp PHLG
(Pseudomonas
protegens) 		3 / 3 GLU A 160
HIS A 129
HIS A 270
 ZN  A 295 (-2.9A)
ZN  A 295 (-3.3A)
ZN  A 295 (-3.3A)
 0.67A 1oe2A-3hwpA:
undetectable		 1oe2A-3hwpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 12 ALA A 158
HIS A 129
GLU A 160
HIS A 270
GLU A 274
 None
ZN  A 295 (-3.3A)
ZN  A 295 (-2.9A)
ZN  A 295 (-3.3A)
ZN  A 295 (-2.5A)
 1.15A 2c6nA-3hwpA:
undetectable		 2c6nA-3hwpA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3hwp PHLG
(Pseudomonas
protegens) 		4 / 5 LEU A  19
ASN A  23
PHE A  36
ALA A 128
 None
 1.06A 2cizA-3hwpA:
undetectable		 2cizA-3hwpA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3hwp PHLG
(Pseudomonas
protegens) 		3 / 3 PHE A   9
CYH A 273
PHE A 125
 None
 1.04A 3cr5X-3hwpA:
undetectable		 3cr5X-3hwpA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 12 LEU A 181
SER A 178
ILE A  68
PHE A 240
ASP A 172
 None
 1.17A 3ko0A-3hwpA:
undetectable
3ko0B-3hwpA:
undetectable
3ko0C-3hwpA:
undetectable
3ko0D-3hwpA:
undetectable		 3ko0A-3hwpA:
15.77
3ko0B-3hwpA:
15.77
3ko0C-3hwpA:
15.77
3ko0D-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 11 PHE A 240
ASP A 172
LEU A 181
SER A 178
ILE A  68
 None
 1.13A 3ko0A-3hwpA:
undetectable
3ko0B-3hwpA:
undetectable
3ko0C-3hwpA:
undetectable
3ko0D-3hwpA:
undetectable		 3ko0A-3hwpA:
15.77
3ko0B-3hwpA:
15.77
3ko0C-3hwpA:
15.77
3ko0D-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 11 LEU A 181
SER A 178
ILE A  68
PHE A 240
ASP A 172
 None
 1.17A 3ko0C-3hwpA:
undetectable
3ko0D-3hwpA:
undetectable
3ko0E-3hwpA:
undetectable
3ko0F-3hwpA:
undetectable		 3ko0C-3hwpA:
15.77
3ko0D-3hwpA:
15.77
3ko0E-3hwpA:
15.77
3ko0F-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 11 ASP A 172
PHE A 240
LEU A 181
SER A 178
ILE A  68
 None
 1.17A 3ko0C-3hwpA:
undetectable
3ko0D-3hwpA:
undetectable
3ko0E-3hwpA:
undetectable
3ko0F-3hwpA:
undetectable		 3ko0C-3hwpA:
15.77
3ko0D-3hwpA:
15.77
3ko0E-3hwpA:
15.77
3ko0F-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 11 ASP A 172
PHE A 240
LEU A 181
SER A 178
ILE A  68
 None
 1.21A 3ko0A-3hwpA:
undetectable
3ko0B-3hwpA:
undetectable
3ko0I-3hwpA:
undetectable
3ko0J-3hwpA:
undetectable		 3ko0A-3hwpA:
15.77
3ko0B-3hwpA:
15.77
3ko0I-3hwpA:
15.77
3ko0J-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 12 LEU A 181
SER A 178
ILE A  68
PHE A 240
ASP A 172
 None
 1.18A 3ko0K-3hwpA:
undetectable
3ko0L-3hwpA:
undetectable
3ko0S-3hwpA:
undetectable
3ko0T-3hwpA:
undetectable		 3ko0K-3hwpA:
15.77
3ko0L-3hwpA:
15.77
3ko0S-3hwpA:
15.77
3ko0T-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 12 LEU A 181
SER A 178
ILE A  68
ASP A 172
PHE A 240
 None
 1.16A 3ko0M-3hwpA:
undetectable
3ko0N-3hwpA:
undetectable
3ko0O-3hwpA:
undetectable
3ko0P-3hwpA:
undetectable		 3ko0M-3hwpA:
15.77
3ko0N-3hwpA:
15.77
3ko0O-3hwpA:
15.77
3ko0P-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 11 ASP A 172
PHE A 240
LEU A 181
SER A 178
ILE A  68
 None
 1.20A 3ko0K-3hwpA:
undetectable
3ko0L-3hwpA:
undetectable
3ko0M-3hwpA:
undetectable
3ko0N-3hwpA:
undetectable		 3ko0K-3hwpA:
15.77
3ko0L-3hwpA:
15.77
3ko0M-3hwpA:
15.77
3ko0N-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 11 LEU A 181
SER A 178
ILE A  68
PHE A 240
ASP A 172
 None
 1.17A 3ko0O-3hwpA:
undetectable
3ko0P-3hwpA:
undetectable
3ko0Q-3hwpA:
undetectable
3ko0R-3hwpA:
undetectable		 3ko0O-3hwpA:
15.77
3ko0P-3hwpA:
15.77
3ko0Q-3hwpA:
15.77
3ko0R-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 12 PHE A 240
ASP A 172
LEU A 181
SER A 178
ILE A  68
 None
 1.16A 3ko0M-3hwpA:
undetectable
3ko0N-3hwpA:
undetectable
3ko0O-3hwpA:
undetectable
3ko0P-3hwpA:
undetectable		 3ko0M-3hwpA:
15.77
3ko0N-3hwpA:
15.77
3ko0O-3hwpA:
15.77
3ko0P-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 10 PHE A 240
ASP A 172
LEU A 181
SER A 178
ILE A  68
 None
 1.17A 3ko0O-3hwpA:
undetectable
3ko0P-3hwpA:
undetectable
3ko0Q-3hwpA:
undetectable
3ko0R-3hwpA:
undetectable		 3ko0O-3hwpA:
15.77
3ko0P-3hwpA:
15.77
3ko0Q-3hwpA:
15.77
3ko0R-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3hwp PHLG
(Pseudomonas
protegens) 		3 / 3 ARG A 239
PHE A 240
PRO A 241
 None
 0.52A 3zoaB-3hwpA:
undetectable		 3zoaB-3hwpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hwp PHLG
(Pseudomonas
protegens) 		3 / 3 LEU A  86
PRO A  87
ARG A  70
 None
 0.62A 4klrB-3hwpA:
undetectable		 4klrB-3hwpA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3hwp PHLG
(Pseudomonas
protegens) 		3 / 3 PRO A  63
VAL A 213
HIS A 214
 None
 0.71A 4pevC-3hwpA:
undetectable		 4pevC-3hwpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 12 HIS A 129
GLU A 160
HIS A 270
PHE A 275
GLU A 274
 ZN  A 295 (-3.3A)
ZN  A 295 (-2.9A)
ZN  A 295 (-3.3A)
None
ZN  A 295 (-2.5A)
 1.08A 4r7lA-3hwpA:
undetectable		 4r7lA-3hwpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3hwp PHLG
(Pseudomonas
protegens) 		3 / 3 TRP A 230
ARG A 228
LEU A 181
 None
 0.97A 5dbyA-3hwpA:
undetectable		 5dbyA-3hwpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3hwp PHLG
(Pseudomonas
protegens) 		4 / 6 PHE A  12
THR A  10
TYR A  11
TYR A 265
 None
 1.44A 5lrbA-3hwpA:
undetectable		 5lrbA-3hwpA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3hwp PHLG
(Pseudomonas
protegens) 		4 / 6 THR A 183
TYR A 186
TYR A 152
PHE A 216
 None
 1.00A 5lrbA-3hwpA:
undetectable		 5lrbA-3hwpA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 12 ILE A  50
VAL A 213
VAL A  93
ALA A 268
LEU A 215
 None
 1.49A 6a7pB-3hwpA:
undetectable		 6a7pB-3hwpA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 10 MET A 212
SER A 196
LEU A  61
ASP A 271
SER A 227
 None
 1.28A 6dlzA-3hwpA:
undetectable
6dlzD-3hwpA:
undetectable		 6dlzA-3hwpA:
15.47
6dlzD-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 10 MET A 212
SER A 196
LEU A  61
ASP A 271
SER A 227
 None
 1.29A 6dlzB-3hwpA:
undetectable
6dlzC-3hwpA:
undetectable		 6dlzB-3hwpA:
15.47
6dlzC-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 10 SER A 227
MET A 212
SER A 196
LEU A  61
ASP A 271
 None
 1.29A 6dlzB-3hwpA:
undetectable
6dlzC-3hwpA:
undetectable		 6dlzB-3hwpA:
15.47
6dlzC-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 11 SER A 227
MET A 212
SER A 196
LEU A  61
ASP A 271
 None
 1.29A 6dlzA-3hwpA:
undetectable
6dlzD-3hwpA:
undetectable		 6dlzA-3hwpA:
15.47
6dlzD-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 10 MET A 212
SER A 196
LEU A  61
ASP A 271
SER A 227
 None
 1.28A 6dm1A-3hwpA:
undetectable
6dm1D-3hwpA:
undetectable		 6dm1A-3hwpA:
15.47
6dm1D-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 10 MET A 212
SER A 196
LEU A  61
ASP A 271
SER A 227
 None
 1.30A 6dm1B-3hwpA:
undetectable
6dm1C-3hwpA:
undetectable		 6dm1B-3hwpA:
15.47
6dm1C-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 10 SER A 227
MET A 212
SER A 196
LEU A  61
ASP A 271
 None
 1.28A 6dm1B-3hwpA:
undetectable
6dm1C-3hwpA:
undetectable		 6dm1B-3hwpA:
15.47
6dm1C-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hwp PHLG
(Pseudomonas
protegens) 		5 / 11 SER A 227
MET A 212
SER A 196
LEU A  61
ASP A 271
 None
 1.30A 6dm1A-3hwpA:
undetectable
6dm1D-3hwpA:
undetectable		 6dm1A-3hwpA:
15.47
6dm1D-3hwpA:
15.47