SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hx1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 3hx1 SLR1951 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  83
VAL A 110
ILE A  44
GLY A  35
ILE A 102
 None
 0.72A 1hxbA-3hx1A:
undetectable		 1hxbA-3hx1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hx1 SLR1951 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 ILE A  96
LEU A  14
ILE A  13
HIS A  12
 None
 0.93A 2azxA-3hx1A:
undetectable		 2azxA-3hx1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3hx1 SLR1951 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  42
LEU A  56
VAL A  25
ARG A  23
VAL A 110
 None
 1.16A 2vn0A-3hx1A:
undetectable		 2vn0A-3hx1A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 3hx1 SLR1951 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A  54
ASP A  72
ILE A  16
ILE A  96
ILE A  70
 None
 1.01A 3s45A-3hx1A:
undetectable		 3s45A-3hx1A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3hx1 SLR1951 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY A  21
ASP A  18
ARG A  22
ARG A  23
 None
 1.17A 6dwdA-3hx1A:
undetectable
6dwdC-3hx1A:
undetectable		 6dwdA-3hx1A:
14.00
6dwdC-3hx1A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3hx1 SLR1951 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLY A  21
ASP A  18
ARG A  22
ARG A  23
 None
 1.16A 6dwdB-3hx1A:
undetectable
6dwdD-3hx1A:
undetectable		 6dwdB-3hx1A:
14.00
6dwdD-3hx1A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3hx1 SLR1951 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 ARG A  22
ARG A  23
GLY A  21
ASP A  18
 None
 1.15A 6dwjB-3hx1A:
undetectable
6dwjD-3hx1A:
undetectable		 6dwjB-3hx1A:
14.00
6dwjD-3hx1A:
14.00