SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 230
LEU A 184
MET A 159
VAL A 157
 None
 1.04A 1fduB-3hx3A:
undetectable		 1fduB-3hx3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A 217
SER A 214
PHE A 173
LEU A 258
 None
None
RET  A 400 (-3.6A)
RET  A 400 ( 4.9A)
 1.08A 1qcaA-3hx3A:
undetectable		 1qcaA-3hx3A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A  76
GLY A  77
ARG A 115
 None
 0.60A 1t9wA-3hx3A:
undetectable		 1t9wA-3hx3A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 145
ILE A 140
GLY A 143
TYR A 296
 None
 1.01A 2jkjD-3hx3A:
undetectable		 2jkjD-3hx3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 145
ILE A 140
GLY A 143
TYR A 296
 None
 1.01A 2jkjF-3hx3A:
undetectable		 2jkjF-3hx3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A 239
PHE A 204
PHE A 247
 None
 0.74A 3lk0D-3hx3A:
undetectable		 3lk0D-3hx3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		4 / 5 ARG A  87
ARG A 115
GLY A 116
GLU A 112
 None
 1.13A 4z3oA-3hx3A:
undetectable
4z3oB-3hx3A:
undetectable		 4z3oA-3hx3A:
17.52
4z3oB-3hx3A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 200
LEU A 184
PHE A 235
THR A 193
ALA A 179
 None
 1.23A 5x5qB-3hx3A:
undetectable		 5x5qB-3hx3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 278
GLY A 275
PHE A 276
VAL A 268
 None
 1.05A 6hu9S-3hx3A:
undetectable
6hu9q-3hx3A:
undetectable		 6hu9S-3hx3A:
15.50
6hu9q-3hx3A:
16.95