SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 9 LEU A1123
ILE A1047
VAL A1144
PHE A1089
GLN A1117
 None
 1.49A 1gx8A-3hx6A:
undetectable		 1gx8A-3hx6A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 6 PRO A 789
ASP A 865
ASN A 869
TYR A 809
 None
 1.20A 1hpkA-3hx6A:
undetectable		 1hpkA-3hx6A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 11 ASP A 822
PHE A 740
VAL A 747
ILE A 749
ILE A 776
 None
 1.41A 1tcoC-3hx6A:
undetectable		 1tcoC-3hx6A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 964
VAL A 938
VAL A 804
ILE A 820
 None
 0.81A 1uwhA-3hx6A:
undetectable		 1uwhA-3hx6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 964
VAL A 938
VAL A 804
ILE A 820
 None
 0.81A 1uwhB-3hx6A:
undetectable		 1uwhB-3hx6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 820
HIS A 797
ASP A 855
ASP A 851
GLY A 856
 None
None
CA  A   1 (-2.8A)
CA  A   1 (-3.4A)
None
 1.08A 1zz1A-3hx6A:
undetectable		 1zz1A-3hx6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 820
HIS A 797
ASP A 855
ASP A 851
GLY A 856
 None
None
CA  A   1 (-2.8A)
CA  A   1 (-3.4A)
None
 1.08A 1zz1C-3hx6A:
undetectable		 1zz1C-3hx6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 645
ALA A 861
LEU A 849
ALA A 850
MET A1046
 None
 1.28A 2jjpA-3hx6A:
undetectable		 2jjpA-3hx6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		3 / 3 ASP A1030
THR A1059
PRO A1060
 None
 0.69A 2pynB-3hx6A:
undetectable		 2pynB-3hx6A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		3 / 3 ASP A1030
THR A1059
PRO A1060
 None
 0.66A 2q64B-3hx6A:
undetectable		 2q64B-3hx6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		3 / 3 ASP A1030
THR A1059
PRO A1060
 None
 0.70A 2qakB-3hx6A:
undetectable		 2qakB-3hx6A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		3 / 3 SER A1085
ARG A1083
GLN A1010
 None
 0.65A 2xnrA-3hx6A:
undetectable		 2xnrA-3hx6A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 8 GLN A1051
GLY A1147
PRO A1078
GLY A1082
 None
 0.88A 2y6rB-3hx6A:
undetectable		 2y6rB-3hx6A:
26.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 6 THR A1087
VAL A1088
LEU A1091
SER A1113
 None
 1.26A 3b6rB-3hx6A:
undetectable		 3b6rB-3hx6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 761
LEU A 759
SER A 751
VAL A 747
 None
 0.91A 3d2tB-3hx6A:
undetectable		 3d2tB-3hx6A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 690
GLY A 758
GLY A 750
LEU A 752
LEU A 748
 None
 1.16A 3e23A-3hx6A:
undetectable		 3e23A-3hx6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 855
ASP A 851
TYR A 936
ARG A 929
 CA  A   1 (-2.8A)
CA  A   1 (-3.4A)
None
None
 1.23A 3s3oA-3hx6A:
undetectable		 3s3oA-3hx6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		3 / 3 ASP A1030
THR A1059
PRO A1060
 None
 0.56A 3tkgD-3hx6A:
undetectable		 3tkgD-3hx6A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 759
ILE A 821
ILE A 749
ILE A 820
ARG A 848
 None
 1.04A 3uj6A-3hx6A:
undetectable		 3uj6A-3hx6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 849
PHE A 873
VAL A 804
PRO A 847
GLY A 868
 None
 1.32A 4hvcB-3hx6A:
undetectable		 4hvcB-3hx6A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 8 ARG A1093
GLN A1117
THR A1073
ARG A1003
 None
 0.77A 4k87A-3hx6A:
undetectable		 4k87A-3hx6A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 849
PHE A 873
VAL A 804
PRO A 847
GLY A 868
 None
 1.26A 4ydqA-3hx6A:
undetectable		 4ydqA-3hx6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 836
GLY A 868
SER A 910
ARG A 957
GLY A 839
 None
 1.05A 5gwxA-3hx6A:
undetectable		 5gwxA-3hx6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 836
GLY A 868
SER A 910
ARG A 957
GLY A 839
 None
 1.06A 5hikA-3hx6A:
undetectable		 5hikA-3hx6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 12 LYS A 790
GLY A 750
ASP A 763
VAL A 764
THR A 765
 None
 1.16A 5kpcB-3hx6A:
undetectable		 5kpcB-3hx6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 968
THR A 969
LEU A 870
LEU A 908
 None
 1.27A 5m5kB-3hx6A:
undetectable		 5m5kB-3hx6A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		5 / 9 PHE A 788
SER A 810
SER A 811
GLY A 785
THR A 922
 None
 1.49A 6awpA-3hx6A:
undetectable		 6awpA-3hx6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1
(Pseudomonas
aeruginosa) 		4 / 5 GLN A1056
THR A1057
THR A1004
GLY A1119
 None
 1.08A 6gbnC-3hx6A:
undetectable		 6gbnC-3hx6A:
22.28