SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Schistosoma
mansoni) 		5 / 11 LEU A 149
LEU A 118
LEU A  63
LEU A 173
LEU A 117
 None
 1.26A 1mx1B-3hxgA:
undetectable		 1mx1B-3hxgA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Schistosoma
mansoni) 		5 / 11 PRO A  69
LEU A  34
VAL A  50
PHE A  59
THR A  66
 None
 1.39A 3n23C-3hxgA:
undetectable		 3n23C-3hxgA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Schistosoma
mansoni) 		4 / 5 GLY A 137
TRP A 152
ALA A 138
PHE A 181
 None
 1.31A 3wqwA-3hxgA:
undetectable		 3wqwA-3hxgA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Schistosoma
mansoni) 		5 / 12 GLY A 137
ILE A 135
SER A 150
VAL A 151
ILE A 165
 None
 0.99A 4ax8A-3hxgA:
undetectable		 4ax8A-3hxgA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-BINDING PROTEIN 1
(Schistosoma
mansoni;
Homo
sapiens) 		5 / 12 ILE A  56
HIS A  24
GLY A 123
ILE A 122
GLY C   4
 None
 0.97A 5d4uD-3hxgA:
undetectable		 5d4uD-3hxgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-BINDING PROTEIN 1
(Homo
sapiens;
Schistosoma
mansoni) 		4 / 7 ARG C   5
ASP A 132
ASP A  28
GLY A 123
 None
 1.10A 5hwaA-3hxgC:
undetectable		 5hwaA-3hxgC:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Schistosoma
mansoni) 		4 / 8 TRP A  43
ARG A  99
GLN A 187
TRP A  89
 GTA  A   1 (-3.4A)
None
None
GTA  A   1 (-3.6A)
 1.41A 5tzoB-3hxgA:
undetectable		 5tzoB-3hxgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Schistosoma
mansoni) 		3 / 3 LEU A 149
VAL A 110
ASP A 111
 None
 0.65A 5x23A-3hxgA:
undetectable		 5x23A-3hxgA:
18.97