SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		3 / 3 GLU A 286
TYR A 278
PHE A 250
 None
 0.96A 1eqbB-3hxjA:
undetectable		 1eqbB-3hxjA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		3 / 3 GLU A 286
TYR A 278
PHE A 250
 None
 0.96A 1eqbA-3hxjA:
undetectable		 1eqbA-3hxjA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		3 / 3 GLU A 286
TYR A 278
PHE A 250
 None
 0.96A 1eqbD-3hxjA:
undetectable		 1eqbD-3hxjA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		3 / 3 GLU A 286
TYR A 278
PHE A 250
 None
 0.97A 1eqbC-3hxjA:
undetectable		 1eqbC-3hxjA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		4 / 6 TYR A 198
ASP A 195
ASN A 175
GLU A 168
 None
 1.31A 1rjdC-3hxjA:
undetectable		 1rjdC-3hxjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		4 / 4 GLY A 271
SER A 258
VAL A 261
LEU A 277
 None
 1.18A 1yajB-3hxjA:
undetectable		 1yajB-3hxjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		5 / 5 LEU A  35
ASP A 303
GLY A 263
PRO A 300
VAL A 301
 None
 1.40A 2aojA-3hxjA:
undetectable		 2aojA-3hxjA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		4 / 7 TYR A 120
VAL A 112
ILE A 138
ASP A 116
 None
 1.24A 2x45B-3hxjA:
undetectable		 2x45B-3hxjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		4 / 7 TYR A 120
VAL A 112
ILE A 138
ASP A 116
 None
 1.24A 2x45C-3hxjA:
undetectable		 2x45C-3hxjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		4 / 7 ASP A 116
ILE A 162
SER A 114
TYR A 120
 None
 0.93A 3pglA-3hxjA:
undetectable		 3pglA-3hxjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		4 / 7 ASP A 234
ILE A 280
SER A 232
TYR A 238
 None
 0.83A 3pglA-3hxjA:
undetectable		 3pglA-3hxjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		5 / 12 THR A 218
TYR A 191
PRO A 260
ILE A 302
ILE A 268
 None
 1.03A 4eb6B-3hxjA:
undetectable
4eb6C-3hxjA:
undetectable		 4eb6B-3hxjA:
20.67
4eb6C-3hxjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		4 / 4 VAL A 230
ALA A 239
ILE A 222
THR A 227
 None
 1.02A 5e4dB-3hxjA:
undetectable		 5e4dB-3hxjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hxj PYRROLO-QUINOLINE
QUINONE
(Methanococcus
maripaludis) 		4 / 4 LEU A 159
TYR A 139
PRO A 142
ILE A 143
 None
 1.20A 5esgA-3hxjA:
undetectable		 5esgA-3hxjA:
22.64