SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 9 ILE A  46
LEU A 124
GLU A  61
ALA A  66
VAL A  76
 None
 1.15A 1ctrA-3hxkA:
undetectable		 1ctrA-3hxkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		6 / 12 GLY A  51
GLY A  52
GLY A  53
SER A 127
TRP A 161
HIS A 231
 None
 0.98A 1dx6A-3hxkA:
15.5		 1dx6A-3hxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 10 LEU A 124
LEU A 235
TRP A 254
ALA A  66
LEU A  70
 None
 1.14A 1pxxA-3hxkA:
undetectable		 1pxxA-3hxkA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 12 GLY A  51
GLY A  52
GLY A  53
SER A 127
HIS A 231
 None
 0.48A 1qtiA-3hxkA:
15.7		 1qtiA-3hxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 8 LEU A  65
GLU A  61
THR A 196
TYR A 152
 None
 0.84A 1qvtA-3hxkA:
undetectable		 1qvtA-3hxkA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 12 GLY A  51
GLY A  52
GLY A  53
SER A 127
HIS A 231
 None
 0.47A 1w6rA-3hxkA:
16.0		 1w6rA-3hxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 10 ASP A 164
GLY A  52
GLY A  53
SER A 127
HIS A 231
 None
 1.23A 1w76B-3hxkA:
15.6		 1w76B-3hxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		3 / 3 ASN A  80
TRP A  26
GLN A  59
 None
 1.18A 1xoqA-3hxkA:
undetectable		 1xoqA-3hxkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 9 GLY A  52
GLY A  53
SER A 127
ALA A 128
HIS A 231
 None
 0.63A 2aceA-3hxkA:
15.5		 2aceA-3hxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 8 GLY A  52
GLY A  53
ALA A 128
HIS A 231
 None
 0.47A 2ha4A-3hxkA:
16.3		 2ha4A-3hxkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 7 GLY A  52
GLY A  53
ALA A 128
HIS A 231
 None
 0.48A 2ha4B-3hxkA:
16.4		 2ha4B-3hxkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 8 SER A 207
THR A 155
ALA A 133
ALA A 134
 None
 0.95A 3ax9B-3hxkA:
undetectable		 3ax9B-3hxkA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 8 SER A 207
THR A 155
ALA A 133
ALA A 134
 None
 1.01A 3ns1L-3hxkA:
undetectable		 3ns1L-3hxkA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 7 GLY A  52
GLY A  53
SER A 127
HIS A 231
 None
 0.36A 3o9mA-3hxkA:
16.9		 3o9mA-3hxkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 6 GLY A  51
GLY A  52
SER A 127
TRP A 161
HIS A 231
 None
 1.24A 3o9mB-3hxkA:
16.7		 3o9mB-3hxkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 6 GLY A  52
GLY A  53
SER A 127
TRP A 161
HIS A 231
 None
 1.07A 3o9mB-3hxkA:
16.7		 3o9mB-3hxkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 5 SER A 156
PRO A 203
TYR A 205
VAL A 202
 None
 1.31A 3sufC-3hxkA:
undetectable		 3sufC-3hxkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 11 LEU A 214
VAL A 184
LEU A 150
VAL A 154
THR A 155
 None
 1.14A 3tbgA-3hxkA:
undetectable		 3tbgA-3hxkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 10 LEU A 214
VAL A 184
LEU A 150
VAL A 154
THR A 155
 None
 1.05A 3tbgC-3hxkA:
undetectable		 3tbgC-3hxkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 12 LEU A 214
TYR A 152
HIS A 195
ALA A 258
LEU A 124
 None
 1.34A 3tm4A-3hxkA:
undetectable		 3tm4A-3hxkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 12 GLY A  51
GLY A  52
GLY A  53
SER A 127
HIS A 231
 None
 0.41A 4ey6A-3hxkA:
4.4		 4ey6A-3hxkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 12 GLY A  51
GLY A  52
GLY A  53
SER A 127
HIS A 231
 None
 0.50A 4ey6B-3hxkA:
15.9		 4ey6B-3hxkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 5 HIS A 231
TYR A  81
GLY A 129
SER A 127
 None
 1.26A 4fu8A-3hxkA:
undetectable		 4fu8A-3hxkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 7 GLY A 130
GLY A  51
SER A  58
LEU A  65
 None
 0.85A 5izfA-3hxkA:
undetectable		 5izfA-3hxkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 10 GLY A 201
VAL A 154
ASN A 206
PRO A 162
GLY A 160
 None
 1.34A 5vncC-3hxkA:
6.6		 5vncC-3hxkA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 6 TRP A 161
SER A 127
HIS A 231
GLU A  61
 None
 1.37A 5x7pA-3hxkA:
undetectable		 5x7pA-3hxkA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 6 TRP A 161
SER A 127
HIS A 231
GLU A  61
 None
 1.39A 5x7pB-3hxkA:
undetectable		 5x7pB-3hxkA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 6 TRP A 161
SER A 127
HIS A 231
GLU A  61
 None
 1.39A 5x7qA-3hxkA:
undetectable		 5x7qA-3hxkA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 6 TRP A 161
SER A 127
HIS A 231
GLU A  61
 None
 1.44A 5x7qB-3hxkA:
undetectable		 5x7qB-3hxkA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 6 TRP A 161
SER A 127
HIS A 231
GLU A  61
 None
 1.40A 5x7rA-3hxkA:
undetectable		 5x7rA-3hxkA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 6 TRP A 161
SER A 127
HIS A 231
GLU A  61
 None
 1.42A 5x7rB-3hxkA:
undetectable		 5x7rB-3hxkA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 7 GLY A  53
GLY A  52
PRO A  50
GLY A 125
GLY A 130
 None
 1.08A 6ag0A-3hxkA:
undetectable		 6ag0A-3hxkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		4 / 8 LEU A 214
GLU A 182
THR A 188
ASN A 179
 None
 1.25A 6c71B-3hxkA:
undetectable		 6c71B-3hxkA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3hxk SUGAR HYDROLASE
(Lactococcus
lactis) 		5 / 10 GLU A  61
GLY A  51
GLY A  52
ALA A 128
GLY A 232
 None
 0.93A 6e5zA-3hxkA:
4.2		 6e5zA-3hxkA:
23.02