SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		4 / 7 LEU A 405
ALA A 420
VAL A 433
VAL A 435
 None
 0.77A 1epbA-3hxlA:
undetectable		 1epbA-3hxlA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		3 / 3 ALA A 275
VAL A 270
TRP A 269
 None
 0.86A 1kqeA-3hxlA:
undetectable
1kqeE-3hxlA:
undetectable		 1kqeA-3hxlA:
9.52
1kqeE-3hxlA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		3 / 3 ALA A 275
VAL A 270
TRP A 269
 None
 0.84A 1kqeB-3hxlA:
undetectable
1kqeD-3hxlA:
undetectable		 1kqeB-3hxlA:
9.52
1kqeD-3hxlA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		3 / 3 TRP A 269
ALA A 275
VAL A 270
 None
 0.86A 1kqeB-3hxlA:
undetectable
1kqeD-3hxlA:
undetectable		 1kqeB-3hxlA:
9.52
1kqeD-3hxlA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		3 / 3 TRP A 269
ALA A 275
VAL A 270
 None
 0.84A 1kqeA-3hxlA:
undetectable
1kqeE-3hxlA:
undetectable		 1kqeA-3hxlA:
9.52
1kqeE-3hxlA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		5 / 11 ARG A  73
LEU A 261
VAL A 294
GLY A 287
VAL A 253
 None
 1.04A 2nnpB-3hxlA:
undetectable		 2nnpB-3hxlA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		4 / 7 ALA A 214
THR A 215
ALA A 218
ARG A 222
 None
 0.95A 2ql8A-3hxlA:
undetectable
2ql8B-3hxlA:
undetectable		 2ql8A-3hxlA:
18.05
2ql8B-3hxlA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		4 / 7 GLY A 181
ASN A  91
ALA A 112
ILE A  41
 None
 0.79A 3a2qA-3hxlA:
undetectable		 3a2qA-3hxlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		3 / 3 THR A 262
SER A 207
LYS A 213
 None
 1.21A 3aocC-3hxlA:
undetectable		 3aocC-3hxlA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		4 / 6 TYR A 288
VAL A 234
THR A 267
PHE A 314
 None
 1.39A 3ltwA-3hxlA:
undetectable		 3ltwA-3hxlA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		3 / 3 ALA A  82
GLN A 232
GLY A 245
 None
 0.52A 4odoC-3hxlA:
undetectable		 4odoC-3hxlA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		4 / 6 LEU A 175
LEU A 136
THR A 170
VAL A 100
 None
 0.91A 4udaA-3hxlA:
undetectable		 4udaA-3hxlA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		4 / 7 ILE A 353
ARG A 345
ILE A 396
MET A 387
 None
 0.99A 4xumA-3hxlA:
undetectable		 4xumA-3hxlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		4 / 7 ASN A 251
VAL A 294
ALA A 291
GLY A 287
 None
 0.91A 5fpdB-3hxlA:
undetectable		 5fpdB-3hxlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		5 / 9 LEU A 205
LEU A 212
ILE A  41
LEU A  74
ALA A 187
 None
 1.36A 5og9A-3hxlA:
undetectable		 5og9A-3hxlA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 3hxl UNCHARACTERIZED
PROTEIN DSY3957
(Desulfitobacteri
um
hafniense) 		4 / 4 LEU A  72
ASP A  69
GLN A  71
VAL A 234
 None
 1.40A 6bzoF-3hxlA:
undetectable		 6bzoF-3hxlA:
23.68