SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3hxs THIOREDOXIN
(Bacteroides
fragilis) 		4 / 8 PHE A 111
ASP A  57
ILE A 109
LEU A 130
 None
 0.94A 1hmyA-3hxsA:
undetectable		 1hmyA-3hxsA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3hxs THIOREDOXIN
(Bacteroides
fragilis) 		5 / 12 TYR A  48
TYR A  87
LEU A  97
PHE A  58
VAL A 112
 None
 1.08A 1vpoH-3hxsA:
undetectable
1vpoL-3hxsA:
undetectable		 1vpoH-3hxsA:
20.37
1vpoL-3hxsA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3hxs THIOREDOXIN
(Bacteroides
fragilis) 		5 / 12 LEU A 138
LEU A 139
ILE A  84
ILE A  86
LEU A 130
 None
 0.99A 2bdmA-3hxsA:
undetectable		 2bdmA-3hxsA:
14.65