SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ALA A 138
TRP A 142
PHE A 215
GLU A 183
 None
None
None
SSA  A 442 ( 4.7A)
 1.08A 1dmiA-3hxwA:
undetectable
1dmiB-3hxwA:
undetectable		 1dmiA-3hxwA:
23.09
1dmiB-3hxwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 9 ARG A 288
LEU A 258
GLU A 241
ALA A 244
LEU A 240
 None
 1.35A 1mj2A-3hxwA:
undetectable		 1mj2A-3hxwA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ARG A 311
ASP A 285
ASN A 253
 None
 0.71A 1nbhA-3hxwA:
undetectable		 1nbhA-3hxwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ARG A 311
ASP A 285
ASN A 253
 None
 0.70A 1nbhD-3hxwA:
undetectable		 1nbhD-3hxwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 HIS A 286
SER A 289
ARG A 288
VAL A  68
 None
 1.26A 1u1jA-3hxwA:
3.0		 1u1jA-3hxwA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 293
ALA A 291
ILE A 312
ASP A 296
PHE A  38
 None
 1.23A 2ejtA-3hxwA:
undetectable		 2ejtA-3hxwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ILE A 243
GLY A  94
THR A 236
LEU A 114
GLY A 239
 None
None
None
None
SSA  A 442 (-3.5A)
 1.28A 2fn1A-3hxwA:
undetectable		 2fn1A-3hxwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ALA A 316
GLY A 320
GLY A 373
LEU A 374
LEU A 377
 None
 0.97A 2hw2A-3hxwA:
undetectable		 2hw2A-3hxwA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 LEU A  93
THR A   4
ILE A 243
VAL A 340
MET A 341
 None
 1.40A 2n27A-3hxwA:
0.0		 2n27A-3hxwA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 GLN A  45
PHE A  46
PHE A  98
GLY A  94
 None
 1.41A 2qmzA-3hxwA:
undetectable
2qmzB-3hxwA:
undetectable		 2qmzA-3hxwA:
17.41
2qmzB-3hxwA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 LEU A  77
ARG A 311
ILE A 312
LEU A 280
 None
 0.96A 2xkwB-3hxwA:
undetectable		 2xkwB-3hxwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 TYR A 331
GLU A 363
THR A 270
 None
 0.95A 2y7hB-3hxwA:
undetectable		 2y7hB-3hxwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ILE A 256
ARG A 288
ILE A 243
ILE A   7
GLN A 248
 None
 1.31A 2yzqA-3hxwA:
undetectable		 2yzqA-3hxwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 293
ALA A 291
ILE A 312
ASP A 296
PHE A  89
 None
 1.17A 3axtA-3hxwA:
undetectable		 3axtA-3hxwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 THR A  88
PHE A  89
LEU A 293
LEU A  28
 None
 1.14A 3bgdA-3hxwA:
undetectable		 3bgdA-3hxwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 VAL A  49
GLY A  52
PRO A 230
ARG A  56
 None
 0.92A 3bjwA-3hxwA:
undetectable		 3bjwA-3hxwA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 LEU A 370
TYR A 401
LEU A 397
ARG A 318
 None
 1.02A 3f33A-3hxwA:
undetectable		 3f33A-3hxwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 ILE A 287
LEU A 309
VAL A  29
SER A  27
 None
 0.93A 3r9vA-3hxwA:
undetectable
3r9vB-3hxwA:
undetectable		 3r9vA-3hxwA:
22.69
3r9vB-3hxwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 LEU A 359
LEU A 309
VAL A  29
SER A  27
 None
 0.82A 3r9vA-3hxwA:
undetectable
3r9vB-3hxwA:
undetectable		 3r9vA-3hxwA:
22.69
3r9vB-3hxwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 PHE A 259
THR A  88
SER A 289
LEU A 337
VAL A 340
 None
 1.47A 3u9fJ-3hxwA:
undetectable
3u9fL-3hxwA:
undetectable		 3u9fJ-3hxwA:
18.10
3u9fL-3hxwA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 GLU A  91
VAL A 340
LEU A 258
ALA A   5
 None
 1.00A 3uniA-3hxwA:
undetectable		 3uniA-3hxwA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 THR A  88
ALA A  70
PHE A  38
VAL A 358
ILE A 313
 None
 1.48A 4claA-3hxwA:
undetectable		 4claA-3hxwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 PHE A  50
GLY A  42
THR A  63
PHE A  98
 None
 0.84A 4ejjA-3hxwA:
undetectable		 4ejjA-3hxwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 PHE A  50
GLY A  42
THR A  63
PHE A  98
 None
 0.83A 4ejjB-3hxwA:
undetectable		 4ejjB-3hxwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ILE A 287
ILE A 294
PHE A 292
GLY A 345
 None
 0.76A 4hdlA-3hxwA:
undetectable		 4hdlA-3hxwA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 MET A 341
LEU A 359
LEU A 337
MET A 299
ALA A 295
 None
 1.49A 4m11A-3hxwA:
1.0		 4m11A-3hxwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ARG A  60
HIS A  20
SER A  59
 None
 0.84A 4mjwA-3hxwA:
1.7
4mjwB-3hxwA:
undetectable		 4mjwA-3hxwA:
21.44
4mjwB-3hxwA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 SER A  59
ARG A  60
HIS A  20
 None
 0.92A 4mjwA-3hxwA:
1.8
4mjwB-3hxwA:
undetectable		 4mjwA-3hxwA:
21.44
4mjwB-3hxwA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 359
ALA A 316
PHE A 330
ILE A 294
THR A  88
 None
 1.01A 4nkxA-3hxwA:
undetectable		 4nkxA-3hxwA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 359
ALA A 316
PHE A 330
ILE A 294
THR A  88
 None
 0.99A 4nkxD-3hxwA:
undetectable		 4nkxD-3hxwA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 GLU A 137
TYR A 139
GLU A 140
ARG A 155
 None
 1.23A 4r87J-3hxwA:
1.2
4r87L-3hxwA:
undetectable		 4r87J-3hxwA:
18.10
4r87L-3hxwA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ASP A 285
ALA A 291
PHE A  89
THR A  88
ARG A   8
 None
 1.28A 4z7fA-3hxwA:
0.0		 4z7fA-3hxwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ASP A 285
ALA A 291
PHE A  89
THR A  88
ARG A   8
 None
 1.11A 4z7fB-3hxwA:
undetectable		 4z7fB-3hxwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 THR A  88
ASP A 285
TYR A 254
GLY A  81
 None
 1.07A 5hwaA-3hxwA:
undetectable		 5hwaA-3hxwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 10 ARG A  69
HIS A  86
PHE A  90
GLU A 209
GLY A 239
ARG A 242
 SSA  A 442 (-2.7A)
None
SSA  A 442 (-3.5A)
SSA  A 442 (-3.9A)
SSA  A 442 (-3.5A)
SSA  A 442 (-3.8A)
 0.69A 6bniA-3hxwA:
13.4		 6bniA-3hxwA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 10 ARG A  69
HIS A  86
PHE A  90
GLU A 209
GLY A 239
ARG A 242
 SSA  A 442 (-2.7A)
None
SSA  A 442 (-3.5A)
SSA  A 442 (-3.9A)
SSA  A 442 (-3.5A)
SSA  A 442 (-3.8A)
 0.69A 6bniB-3hxwA:
12.0		 6bniB-3hxwA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 ASN A  75
TYR A 307
GLY A 306
ASP A 406
 None
 1.11A 6gh9A-3hxwA:
undetectable		 6gh9A-3hxwA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3hxw ALANYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 GLY A  19
PHE A  15
HIS A  16
VAL A  22
 None
 1.07A 6hu9S-3hxwA:
undetectable
6hu9q-3hxwA:
undetectable		 6hu9S-3hxwA:
12.97
6hu9q-3hxwA:
15.60