SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hy8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		3 / 3 VAL A 140
TRP A 229
TRP A 219
 None
 1.29A 1c4dA-3hy8A:
undetectable
1c4dB-3hy8A:
undetectable		 1c4dA-3hy8A:
3.94
1c4dB-3hy8A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		3 / 3 GLN A 166
HIS A 159
PRO A 201
 None
 0.94A 1d8cA-3hy8A:
undetectable		 1d8cA-3hy8A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		4 / 4 SER A  55
PHE A 232
GLU A 251
GLY A 250
 PO4  A 380 (-3.0A)
None
PO4  A 380 (-2.7A)
None
 1.35A 1icvA-3hy8A:
undetectable
1icvB-3hy8A:
undetectable		 1icvA-3hy8A:
22.97
1icvB-3hy8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		4 / 6 ARG A 138
PHE A 218
ILE A 230
PHE A 232
 None
 1.05A 2qeiA-3hy8A:
undetectable		 2qeiA-3hy8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		4 / 4 ARG A 116
GLY A 118
GLU A 120
SER A 172
 PO4  A 370 ( 3.7A)
None
None
None
 1.30A 2xctS-3hy8A:
undetectable
2xctU-3hy8A:
undetectable		 2xctS-3hy8A:
16.12
2xctU-3hy8A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		4 / 5 ARG A 116
GLY A 118
THR A  87
GLU A 120
 PO4  A 370 ( 3.7A)
None
None
None
 1.08A 5btiA-3hy8A:
undetectable
5btiB-3hy8A:
undetectable		 5btiA-3hy8A:
19.96
5btiB-3hy8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		4 / 5 ARG A 116
GLY A 118
THR A  87
GLU A 120
 PO4  A 370 ( 3.7A)
None
None
None
 1.10A 5btiC-3hy8A:
undetectable
5btiD-3hy8A:
undetectable		 5btiC-3hy8A:
19.96
5btiD-3hy8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		3 / 3 ASP A 122
LEU A  83
ARG A  95
 None
None
FMN  A 390 (-3.5A)
 0.78A 5e8qA-3hy8A:
undetectable		 5e8qA-3hy8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		5 / 12 GLY A 144
GLN A 214
LEU A 149
TYR A 157
PHE A 109
 None
None
None
PO4  A 360 (-3.7A)
None
 1.24A 5fsaB-3hy8A:
undetectable		 5fsaB-3hy8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens) 		3 / 3 PRO A 162
SER A 164
SER A 165
 PLP  A 350 (-4.4A)
None
PLP  A 350 (-3.1A)
 0.63A 6bpyA-3hy8A:
undetectable		 6bpyA-3hy8A:
21.07