SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB151_0 (ILEAL BILE ACID-BINDING PROTEIN)	3hyf	REVERSE TRANSCRIPTASE/RNASEH (Escherichia coli; Human immunodeficiency virus 1)	5 / 12	ILE A 521 ILE A 482 VAL A 442 GLY A 444 LEU A 469	None	1.15A	3em0B-3hyfA: undetectable	3em0B-3hyfA: 24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SG9_B_KANB305_1 (APH(2'')-ID)	3hyf	REVERSE TRANSCRIPTASE/RNASEH (Escherichia coli; Human immunodeficiency virus 1)	4 / 8	ASN A 474 ASP A 549 HIS A 539 ASP A 443	GOL A 699 (-3.8A) MN A 602 ( 3.2A) ON1 A 701 (-3.8A) MN A 602 (-2.5A)	0.89A	3sg9B-3hyfA: undetectable	3sg9B-3hyfA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE3_B_CL6B502_1 (CYTOCHROME P-450)	3hyf	REVERSE TRANSCRIPTASE/RNASEH (Escherichia coli; Human immunodeficiency virus 1)	4 / 5	LEU A 517 ALA A 502 THR A 497 ILE A 495	None	0.95A	4xe3B-3hyfA: undetectable	4xe3B-3hyfA: 14.50