SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 8 PHE A 119
GLY A 117
VAL A  20
PHE A 181
 None
 0.95A 1gsfC-3hyiA:
undetectable		 1gsfC-3hyiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		3 / 3 LEU A 244
PRO A 245
LEU A 248
 None
 0.55A 1hrkA-3hyiA:
undetectable		 1hrkA-3hyiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 6 ILE A  13
SER A  10
ILE A 136
PHE A 181
 None
 1.12A 2q72A-3hyiA:
1.6		 2q72A-3hyiA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 5 LEU A 244
PRO A 245
LEU A 248
ILE A 284
 None
 0.79A 2qd4A-3hyiA:
undetectable		 2qd4A-3hyiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		5 / 11 ILE A  13
LEU A 115
LEU A 182
ILE A 185
LEU A 120
 None
 1.24A 3a50C-3hyiA:
undetectable		 3a50C-3hyiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 4 LEU A 244
PRO A 245
LEU A 248
ILE A 284
 None
 0.90A 4f4dB-3hyiA:
undetectable		 4f4dB-3hyiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		5 / 10 LEU A 118
ILE A 185
GLY A 123
PHE A 114
SER A 113
 None
 1.07A 4fakA-3hyiA:
undetectable		 4fakA-3hyiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		5 / 12 GLY A 160
ASN A 158
ASP A 177
ILE A 172
PHE A 181
 None
 1.09A 4u8vB-3hyiA:
undetectable		 4u8vB-3hyiA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		5 / 12 GLY A 160
ASN A 158
ASP A 177
ILE A 172
PHE A 181
 None
 1.10A 4u95B-3hyiA:
undetectable		 4u95B-3hyiA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		5 / 10 ARG A 249
ARG A 250
ARG A 283
LEU A 281
ILE A 277
 None
 1.24A 4z69I-3hyiA:
2.5		 4z69I-3hyiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 8 GLU A  27
SER A  30
PHE A 114
GLY A 117
 None
 0.98A 5flcB-3hyiA:
undetectable		 5flcB-3hyiA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3hyi PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 8 GLU A  27
SER A  30
PHE A 114
GLY A 117
 None
 0.98A 5flcF-3hyiA:
2.6		 5flcF-3hyiA:
14.17