SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3hyj PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		5 / 11 PHE A 155
VAL A 112
ILE A 185
LEU A 170
ILE A 136
 None
 1.35A 1yatA-3hyjA:
undetectable		 1yatA-3hyjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3hyj PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 8 PHE A 181
THR A 147
GLY A  34
ILE A 185
 None
 0.79A 2a1mB-3hyjA:
undetectable		 2a1mB-3hyjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3hyj PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		5 / 12 PHE A 114
LEU A 118
GLU A 141
LEU A 144
ARG A 168
 None
 1.16A 2bxfA-3hyjA:
undetectable		 2bxfA-3hyjA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3hyj PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		5 / 9 ILE A 185
LEU A 151
THR A 143
GLU A 135
GLY A 160
 None
 1.43A 3nxuB-3hyjA:
undetectable		 3nxuB-3hyjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3hyj PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 6 LEU A 138
ALA A 159
LEU A 151
THR A 147
 None
 1.04A 3rozA-3hyjA:
undetectable		 3rozA-3hyjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3hyj PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 8 GLU A  27
SER A  30
PHE A 114
GLY A 117
 None
 0.93A 5flcB-3hyjA:
undetectable		 5flcB-3hyjA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3hyj PROTEIN DUF199/WHIA
(Thermotoga
maritima) 		4 / 8 GLU A  27
SER A  30
PHE A 114
GLY A 117
 None
 0.93A 5flcF-3hyjA:
undetectable		 5flcF-3hyjA:
10.31