SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		3 / 3 LEU B 372
HIS B 342
ILE B 338
 None
 0.71A 1s9pB-3hymB:
undetectable		 1s9pB-3hymB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		4 / 5 VAL B 408
GLY B 409
VAL B 411
TRP B 418
 None
 0.99A 1tkqB-3hymB:
undetectable		 1tkqB-3hymB:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3hym ANAPHASE-PROMOTING
COMPLEX SUBUNIT
CDC26
CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A   2
PRO B 335
TRP B 337
SER B 301
PHE B 303
 None
 1.44A 1xmuA-3hymA:
undetectable		 1xmuA-3hymA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hym ANAPHASE-PROMOTING
COMPLEX SUBUNIT
CDC26
CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A   2
PRO B 335
TRP B 337
SER B 301
PHE B 303
 None
 1.45A 1xoqB-3hymA:
undetectable		 1xoqB-3hymA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		3 / 3 ALA B 412
THR B 420
PHE B 391
 None
 0.63A 2c6nB-3hymB:
undetectable		 2c6nB-3hymB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		5 / 12 ILE B 338
PHE B 344
ASN B 316
LEU B 310
THR B 359
 None
 1.22A 2w3mB-3hymB:
undetectable		 2w3mB-3hymB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hym ANAPHASE-PROMOTING
COMPLEX SUBUNIT
CDC26
CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		5 / 12 LEU B 380
THR A   7
GLU B 377
LEU B 372
HIS B 342
 None
 1.33A 3g1uA-3hymB:
undetectable		 3g1uA-3hymB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3hym ANAPHASE-PROMOTING
COMPLEX SUBUNIT
CDC26
CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		5 / 12 THR A   7
GLU A  10
LEU B 447
LEU B 376
TYR B 373
 None
 1.46A 3gwxB-3hymA:
undetectable		 3gwxB-3hymA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		3 / 3 LEU B 458
TRP B 418
GLY B 416
 None
 0.78A 3l35A-3hymB:
undetectable
3l35H-3hymB:
undetectable		 3l35A-3hymB:
6.73
3l35H-3hymB:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		3 / 3 LEU B 458
TRP B 418
GLY B 416
 None
 0.74A 3l35B-3hymB:
undetectable
3l35K-3hymB:
undetectable		 3l35B-3hymB:
6.73
3l35K-3hymB:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		4 / 5 THR B 254
GLU B 283
HIS B 289
LEU B 291
 None
 1.24A 5utuH-3hymB:
undetectable		 5utuH-3hymB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens) 		5 / 12 GLY B 334
TYR B 242
HIS B 368
TYR B 243
LEU B 369
 None
 1.38A 6bp4A-3hymB:
undetectable		 6bp4A-3hymB:
22.97