SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 GLY A 112
ALA A 113
VAL A 231
THR A 248
ILE A 226
 None
 0.82A 1c6yB-3hyvA:
undetectable		 1c6yB-3hyvA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 8 GLY A 396
ARG A  22
ILE A  71
LEU A  66
 None
 0.91A 1jg4A-3hyvA:
2.1		 1jg4A-3hyvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 6 PHE A 157
ALA A 160
GLY A 149
TYR A 161
 None
 1.15A 1l5qA-3hyvA:
1.8		 1l5qA-3hyvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 6 PHE A 157
ALA A 160
GLY A 149
TYR A 161
 None
 1.15A 1l7xA-3hyvA:
undetectable		 1l7xA-3hyvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		3 / 3 ALA A 325
HIS A 326
VAL A 329
 None
 0.49A 1lqtB-3hyvA:
8.2		 1lqtB-3hyvA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		3 / 3 ALA A 325
HIS A 326
VAL A 329
 None
 0.50A 1lquB-3hyvA:
8.2		 1lquB-3hyvA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 GLY A  13
GLY A  11
ILE A 398
LEU A 407
PRO A 415
 FAD  A 441 (-3.4A)
FAD  A 441 (-3.3A)
None
LMT  A 600 ( 4.9A)
None
 0.99A 1p91B-3hyvA:
3.0		 1p91B-3hyvA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 8 THR A 296
GLY A  13
THR A  17
VAL A 324
 None
FAD  A 441 (-3.4A)
None
None
 0.74A 2a1mB-3hyvA:
undetectable		 2a1mB-3hyvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 8 ILE A 103
ILE A 289
ILE A 328
ILE A   8
 None
None
None
FAD  A 441 (-4.9A)
 0.67A 2nniA-3hyvA:
undetectable		 2nniA-3hyvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 ALA A 245
PRO A 244
VAL A 231
ILE A 185
PHE A 250
 None
 1.29A 2v95A-3hyvA:
undetectable		 2v95A-3hyvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 5 PHE A 157
ALA A 160
GLY A 149
TYR A 161
 None
 1.16A 3bcrA-3hyvA:
3.6		 3bcrA-3hyvA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 ALA A 323
THR A 296
ILE A 298
PRO A 299
ILE A 317
 None
None
None
None
FAD  A 441 (-4.6A)
 1.07A 3clbB-3hyvA:
undetectable		 3clbB-3hyvA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 10 VAL A 146
ALA A 245
ILE A 226
PRO A 252
ILE A 148
 None
 1.26A 3clbD-3hyvA:
undetectable		 3clbD-3hyvA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 8 GLY A 192
VAL A 206
ILE A 199
VAL A 196
 None
 0.71A 3fi0I-3hyvA:
undetectable		 3fi0I-3hyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 9 MET A 249
ALA A 150
ILE A 215
LEU A 165
ILE A 148
 None
 1.25A 3jw3B-3hyvA:
undetectable		 3jw3B-3hyvA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 7 GLY A 309
CYH A 347
PHE A 359
GLY A 197
 None
PS9  A 800 (-3.5A)
None
None
 0.99A 3ko0M-3hyvA:
undetectable
3ko0P-3hyvA:
undetectable		 3ko0M-3hyvA:
15.16
3ko0P-3hyvA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 10 LEU A  32
ILE A  15
ALA A  16
VAL A 102
VAL A   5
 None
 1.09A 3r9cA-3hyvA:
undetectable		 3r9cA-3hyvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 7 VAL A 275
VAL A 324
PHE A 281
ILE A 298
 None
 0.95A 3zjqA-3hyvA:
undetectable		 3zjqA-3hyvA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 7 VAL A 275
VAL A 324
PHE A 281
ILE A 298
 None
 0.93A 3zjqB-3hyvA:
undetectable		 3zjqB-3hyvA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 LEU A  32
ILE A  71
ILE A  15
ALA A  16
ALA A 325
 None
 0.93A 4enhA-3hyvA:
undetectable		 4enhA-3hyvA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 6 TYR A 388
GLU A 318
VAL A 292
ALA A 104
 None
 0.85A 4nkvC-3hyvA:
undetectable		 4nkvC-3hyvA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 5 ILE A  96
VAL A   6
ILE A   8
VAL A  88
 None
None
FAD  A 441 (-4.9A)
None
 0.69A 4xdtA-3hyvA:
undetectable		 4xdtA-3hyvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		4 / 5 ILE A 185
VAL A 223
ILE A 226
THR A 248
 None
 0.60A 4xdtA-3hyvA:
undetectable		 4xdtA-3hyvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 11 LEU A 171
VAL A 146
ILE A 148
ALA A  49
ILE A 123
 None
 1.09A 5d75A-3hyvA:
undetectable		 5d75A-3hyvA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 11 LEU A 171
VAL A 146
ILE A 148
ALA A  49
ILE A 123
 None
 1.13A 5gpgA-3hyvA:
undetectable		 5gpgA-3hyvA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 LEU A 191
THR A 186
GLY A 149
ILE A 148
MET A 249
 None
 1.08A 5ifuA-3hyvA:
2.9		 5ifuA-3hyvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 10 LEU A 390
ILE A  58
PHE A  39
ALA A  44
VAL A  12
 None
None
None
None
FAD  A 441 (-4.1A)
 1.37A 5m0oA-3hyvA:
undetectable		 5m0oA-3hyvA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 11 ASP A  35
SER A  34
ILE A 103
THR A 105
ILE A  81
 FAD  A 441 (-3.2A)
FAD  A 441 (-3.4A)
None
FAD  A 441 (-4.2A)
None
 0.93A 5y80A-3hyvA:
undetectable		 5y80A-3hyvA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 9 ALA A  16
PHE A  41
GLY A  40
PHE A  39
GLY A  14
 None
 1.28A 6awoA-3hyvA:
undetectable		 6awoA-3hyvA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 9 ALA A  16
PHE A  41
GLY A  40
PHE A  39
GLY A  14
 None
 1.29A 6awqA-3hyvA:
undetectable		 6awqA-3hyvA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3hyv SULFIDE-QUINONE
REDUCTASE
(Aquifex
aeolicus) 		5 / 12 ASN A 288
ILE A  81
VAL A 267
ILE A  96
VAL A 259
 None
None
None
None
SO4  A 433 (-4.0A)
 1.43A 6j21A-3hyvA:
undetectable		 6j21A-3hyvA:
21.13