SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I7Z_A_COCA301_1 (CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION)	3hz8	THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA (Neisseria meningitidis)	4 / 8	TYR A 185 LEU A 202 LEU A 50 GLU A 188	None	1.12A	1i7zA-3hz8A: undetectable	1i7zA-3hz8A: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_A_TEIA3006_1 (XANTHINE DEHYDROGENASE)	3hz8	THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA (Neisseria meningitidis)	5 / 12	LEU A 133 LEU A 137 PHE A 143 ALA A 104 ALA A 105	None	1.15A	1n5xA-3hz8A: undetectable	1n5xA-3hz8A: 10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_B_TEIB4006_1 (XANTHINE DEHYDROGENASE)	3hz8	THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA (Neisseria meningitidis)	5 / 12	LEU A 133 LEU A 137 PHE A 143 ALA A 104 ALA A 105	None	1.15A	1n5xB-3hz8A: undetectable	1n5xB-3hz8A: 10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M66_D_ADND502_2 (ADENOSYLHOMOCYSTEINA SE)	3hz8	THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA (Neisseria meningitidis)	3 / 3	THR A 198 THR A 178 LEU A 35	None	0.68A	5m66D-3hz8A: undetectable	5m66D-3hz8A: 17.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I7Z_A_COCA301_1","CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION","3hz8","THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA","Neisseria meningitidis",4,"TYR A 185;LEU A 202;LEU A  50;GLU A 188","None","1.12A","1i7zA-3hz8A:undetectable","1i7zA-3hz8A:22.36"],["1N5X_A_TEIA3006_1","XANTHINE DEHYDROGENASE","3hz8","THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA","Neisseria meningitidis",5,"LEU A 133;LEU A 137;PHE A 143;ALA A 104;ALA A 105","None","1.15A","1n5xA-3hz8A:undetectable","1n5xA-3hz8A:10.05"],["1N5X_B_TEIB4006_1","XANTHINE DEHYDROGENASE","3hz8","THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA","Neisseria meningitidis",5,"LEU A 133;LEU A 137;PHE A 143;ALA A 104;ALA A 105","None","1.15A","1n5xB-3hz8A:undetectable","1n5xB-3hz8A:10.05"],["5M66_D_ADND502_2","ADENOSYLHOMOCYSTEINASE","3hz8","THIOL:DISULFIDE INTERCHANGE PROTEIN DSBA","Neisseria meningitidis",3,"THR A 198;THR A 178;LEU A  35","None","0.68A","5m66D-3hz8A:undetectable","5m66D-3hz8A:17.09"]]