SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3hzg THYMIDYLATE SYNTHASE
THYX
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  38
VAL A  23
TRP A  47
 None
 0.86A 2cc8A-3hzgA:
undetectable		 2cc8A-3hzgA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3hzg THYMIDYLATE SYNTHASE
THYX
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  38
VAL A  23
TRP A  47
 None
 0.86A 2ccbA-3hzgA:
undetectable		 2ccbA-3hzgA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3hzg THYMIDYLATE SYNTHASE
THYX
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  38
VAL A  23
TRP A  47
 None
 0.85A 2vx9A-3hzgA:
undetectable		 2vx9A-3hzgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 3hzg THYMIDYLATE SYNTHASE
THYX
(Mycobacterium
tuberculosis) 		4 / 5 THR A  15
GLY A  31
PRO A  33
TYR A 189
 None
 1.25A 3u8qA-3hzgA:
undetectable		 3u8qA-3hzgA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hzg THYMIDYLATE SYNTHASE
THYX
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 175
PRO A 176
ARG A 182
 None
 0.62A 4klrB-3hzgA:
undetectable		 4klrB-3hzgA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3hzg THYMIDYLATE SYNTHASE
THYX
(Mycobacterium
tuberculosis) 		3 / 3 SER A 201
ALA A 242
VAL A 232
 None
 0.64A 4o2bC-3hzgA:
undetectable		 4o2bC-3hzgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3hzg THYMIDYLATE SYNTHASE
THYX
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 189
GLY A  32
PRO A  33
 None
 0.62A 4qwpA-3hzgA:
undetectable		 4qwpA-3hzgA:
23.84