SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		3 / 3 ALA A 552
VAL A 547
TRP A 548
 None
 0.88A 1bdwA-3hzjA:
undetectable
1bdwB-3hzjA:
undetectable		 1bdwA-3hzjA:
4.62
1bdwB-3hzjA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		5 / 12 SER A 624
LEU A 603
ILE A 606
ILE A 646
HIS A 633
 None
 1.19A 1kyvA-3hzjA:
undetectable
1kyvE-3hzjA:
undetectable		 1kyvA-3hzjA:
20.32
1kyvE-3hzjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		5 / 12 ILE A 646
HIS A 633
SER A 624
LEU A 603
ILE A 606
 None
 1.22A 1kyvB-3hzjA:
undetectable
1kyvC-3hzjA:
undetectable		 1kyvB-3hzjA:
20.32
1kyvC-3hzjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		5 / 11 LEU A 603
VAL A 713
LEU A 632
LEU A 710
LEU A 631
 None
 1.38A 1mx1B-3hzjA:
2.2		 1mx1B-3hzjA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		5 / 10 ALA A 696
LEU A 678
LEU A 733
LEU A 670
LEU A 736
 None
UNX  A 908 ( 4.7A)
None
None
None
 1.17A 2riwA-3hzjA:
undetectable
2riwB-3hzjA:
undetectable		 2riwA-3hzjA:
20.22
2riwB-3hzjA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		5 / 10 ALA A 696
LEU A 678
LEU A 733
LEU A 670
LEU A 736
 None
UNX  A 908 ( 4.7A)
None
None
None
 1.17A 2xn6A-3hzjA:
undetectable
2xn6B-3hzjA:
undetectable		 2xn6A-3hzjA:
20.33
2xn6B-3hzjA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		3 / 3 TYR A 668
GLU A 671
ASN A 689
 None
UNX  A 902 ( 4.4A)
None
 0.97A 2y7hC-3hzjA:
undetectable		 2y7hC-3hzjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		4 / 8 PHE A 704
PHE A 700
LEU A 736
LEU A 735
 None
 0.89A 4ejgB-3hzjA:
undetectable		 4ejgB-3hzjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		3 / 3 GLU A 541
ARG A 544
HIS A 633
 None
 0.75A 4kf9A-3hzjA:
undetectable		 4kf9A-3hzjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		4 / 7 PHE A 700
ALA A 732
ILE A 779
LEU A 673
 None
 0.98A 4uymB-3hzjA:
undetectable		 4uymB-3hzjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		5 / 6 GLN A 698
PHE A 704
PHE A 708
LEU A 759
PHE A 754
 UNX  A 910 ( 4.6A)
None
UNX  A 901 ( 4.7A)
None
None
 1.47A 5b1bC-3hzjA:
undetectable
5b1bJ-3hzjA:
undetectable		 5b1bC-3hzjA:
23.38
5b1bJ-3hzjA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		4 / 5 ASP A 581
ARG A 584
LEU A 652
MET A 647
 None
 1.23A 5tuiB-3hzjA:
undetectable		 5tuiB-3hzjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		3 / 3 TYR A 564
ARG A 565
THR A 569
 None
UNX  A 906 ( 4.3A)
None
 1.03A 5z84J-3hzjA:
undetectable		 5z84J-3hzjA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens) 		5 / 10 VAL A 535
LEU A 531
LEU A 516
LEU A 550
LEU A 551
 None
 0.99A 6f6nA-3hzjA:
undetectable
6f6nB-3hzjA:
undetectable		 6f6nA-3hzjA:
15.33
6f6nB-3hzjA:
13.82