SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		3 / 4 VAL A 143
TRP A 138
TRP A  46
 None
 1.20A 1gmkA-3hznA:
undetectable
1gmkB-3hznA:
undetectable		 1gmkA-3hznA:
5.74
1gmkB-3hznA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		4 / 4 ALA A  86
VAL A 143
ALA A 140
HIS A 136
 None
None
SIN  A 219 (-3.1A)
None
 1.09A 1q23A-3hznA:
undetectable		 1q23A-3hznA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		4 / 4 ALA A  86
VAL A 143
ALA A 140
HIS A 136
 None
None
SIN  A 219 (-3.1A)
None
 1.17A 1q23F-3hznA:
undetectable		 1q23F-3hznA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		5 / 8 TYR A  68
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 None
MLI  A 226 (-2.8A)
MLI  A 226 (-3.4A)
None
MLI  A 226 (-3.3A)
 0.75A 1ykiA-3hznA:
33.5
1ykiB-3hznA:
33.7		 1ykiA-3hznA:
88.48
1ykiB-3hznA:
88.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		5 / 8 TYR A  68
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 None
MLI  A 226 (-2.8A)
MLI  A 226 (-3.4A)
None
MLI  A 226 (-3.3A)
 0.77A 1ykiA-3hznA:
33.5
1ykiB-3hznA:
33.7		 1ykiA-3hznA:
88.48
1ykiB-3hznA:
88.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		5 / 8 TYR A  68
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 None
MLI  A 226 (-2.8A)
MLI  A 226 (-3.4A)
None
MLI  A 226 (-3.3A)
 0.76A 1ykiC-3hznA:
33.6
1ykiD-3hznA:
33.5		 1ykiC-3hznA:
88.48
1ykiD-3hznA:
88.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		5 / 8 TYR A  68
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 None
MLI  A 226 (-2.8A)
MLI  A 226 (-3.4A)
None
MLI  A 226 (-3.3A)
 0.74A 1ykiC-3hznA:
33.6
1ykiD-3hznA:
33.5		 1ykiC-3hznA:
88.48
1ykiD-3hznA:
88.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		3 / 3 LEU A 132
HIS A 128
MET A 127
 None
 0.81A 3thrD-3hznA:
undetectable		 3thrD-3hznA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		3 / 3 ARG A  73
LYS A  14
LYS A  74
 SIN  A 222 ( 3.1A)
MLI  A 226 ( 4.6A)
MLI  A 226 (-3.4A)
 1.38A 4k50A-3hznA:
undetectable		 4k50A-3hznA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		3 / 3 ARG A  73
LYS A  14
LYS A  74
 SIN  A 222 ( 3.1A)
MLI  A 226 ( 4.6A)
MLI  A 226 (-3.4A)
 1.41A 4k50E-3hznA:
undetectable		 4k50E-3hznA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		3 / 3 ARG A  73
LYS A  14
LYS A  74
 SIN  A 222 ( 3.1A)
MLI  A 226 ( 4.6A)
MLI  A 226 (-3.4A)
 1.38A 4k50I-3hznA:
undetectable		 4k50I-3hznA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Salmonella
enterica) 		4 / 5 SER A  79
ALA A  78
HIS A  80
LEU A 159
 None
None
TLA  A 218 (-4.0A)
None
 1.38A 5dzkf-3hznA:
undetectable
5dzkt-3hznA:
undetectable		 5dzkf-3hznA:
22.18
5dzkt-3hznA:
1.29