SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 ASP A 118
THR A 379
ILE A 376
LEU A 372
ILE A 155
 None
 0.98A 1rx7A-3hzrA:
undetectable		 1rx7A-3hzrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		3 / 3 GLN A 115
ILE A 116
TYR A 156
 None
 0.66A 1vifA-3hzrA:
undetectable		 1vifA-3hzrA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 LEU A  98
ILE A  80
GLN A 105
PHE A 148
ILE A 143
 None
 1.35A 1xotA-3hzrA:
undetectable		 1xotA-3hzrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 8 TYR A 335
ASP A 312
SER A 293
HIS A 302
 None
 1.08A 2bteA-3hzrA:
9.0		 2bteA-3hzrA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 8 TYR A 335
ASP A 312
SER A 293
HIS A 302
 None
 1.05A 2bteD-3hzrA:
9.5		 2bteD-3hzrA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 8 MET A 202
GLN A 115
LEU A 117
LEU A 123
GLY A 194
 None
 1.23A 2qqcH-3hzrA:
undetectable
2qqcK-3hzrA:
undetectable		 2qqcH-3hzrA:
13.62
2qqcK-3hzrA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 6 TYR A  53
MET A 353
ILE A 357
LEU A  92
 None
 1.19A 2wekB-3hzrA:
undetectable		 2wekB-3hzrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 7 TYR A  53
PHE A 321
PHE A 356
ILE A  96
 None
 1.08A 2zseA-3hzrA:
undetectable		 2zseA-3hzrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 11 ASP A 118
THR A 379
ILE A 376
LEU A 372
ILE A 155
 None
 1.03A 3tqbA-3hzrA:
undetectable		 3tqbA-3hzrA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 TYR A 156
TYR A 211
SER A 205
VAL A 250
HIS A 253
 None
 1.42A 3vt7A-3hzrA:
undetectable		 3vt7A-3hzrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 5 GLU A 344
GLY A 343
TYR A 335
ASP A 312
 None
 0.88A 3w9tD-3hzrA:
undetectable		 3w9tD-3hzrA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 GLY A 307
GLY A 295
LEU A 340
SER A 342
CYH A 309
 None
 1.09A 4krhA-3hzrA:
2.8		 4krhA-3hzrA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 GLY A 307
GLY A 295
LEU A 340
SER A 342
CYH A 309
 None
 1.09A 4krhB-3hzrA:
2.9		 4krhB-3hzrA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 PHE A 100
ILE A  34
THR A  78
LEU A  65
LEU A 224
 None
 1.42A 4qynB-3hzrA:
undetectable		 4qynB-3hzrA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 PHE A 100
ILE A  34
THR A  78
LEU A  65
LEU A 224
 None
 1.40A 4qzuA-3hzrA:
undetectable		 4qzuA-3hzrA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		3 / 3 TYR A 166
ARG A 167
THR A 168
 None
 1.05A 5z84J-3hzrA:
undetectable		 5z84J-3hzrA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3hzr TRYPTOPHANYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 8 VAL A 172
GLN A  83
PRO A 199
ILE A 201
 None
 1.06A 6hzpA-3hzrA:
undetectable		 6hzpA-3hzrA:
21.10