SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 VAL A 242
ILE A 231
MET A 264
LEU A 246
 None
 0.93A 1iepB-3hzsA:
undetectable		 1iepB-3hzsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 THR A 135
VAL A  70
ILE A 172
VAL A 139
LEU A  73
 None
 1.43A 1z9hA-3hzsA:
undetectable		 1z9hA-3hzsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 THR A 135
VAL A  70
ILE A 172
VAL A 139
LEU A  73
 None
 1.42A 1z9hB-3hzsA:
undetectable		 1z9hB-3hzsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 THR A 135
VAL A  70
ILE A 172
VAL A 139
LEU A  73
 None
 1.43A 1z9hC-3hzsA:
undetectable		 1z9hC-3hzsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ASN A 224
VAL A 223
ILE A 231
LEU A 214
ALA A 192
 M0E  A 901 (-3.9A)
M0E  A 901 (-4.8A)
None
None
None
 1.27A 2iyfB-3hzsA:
undetectable		 2iyfB-3hzsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 ILE A  97
SER A 221
ARG A 241
TYR A 254
 None
 1.05A 2zw9B-3hzsA:
undetectable		 2zw9B-3hzsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 VAL A 223
ASN A 245
MET A 249
ALA A  95
PHE A  96
 M0E  A 901 (-4.8A)
None
None
None
None
 1.45A 3nuvA-3hzsA:
undetectable		 3nuvA-3hzsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 ASN A 224
VAL A 223
ILE A 231
LEU A 214
ALA A 192
 M0E  A 901 (-3.9A)
M0E  A 901 (-4.8A)
None
None
None
 1.29A 4m83A-3hzsA:
undetectable		 4m83A-3hzsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 SER A 124
ASP A 127
GLN A 251
 None
 0.89A 4oltA-3hzsA:
undetectable
4oltB-3hzsA:
undetectable		 4oltA-3hzsA:
19.52
4oltB-3hzsA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 GLN A 251
SER A 124
ASP A 127
 None
 0.82A 4qwpA-3hzsA:
undetectable
4qwpB-3hzsA:
2.6		 4qwpA-3hzsA:
18.47
4qwpB-3hzsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 MET A  67
GLU A 156
TYR A 142
ILE A 172
ALA A 160
 None
 1.18A 5kvaA-3hzsA:
undetectable		 5kvaA-3hzsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 ASN A  87
ASP A  86
ASN A 170
ASN A 178
 None
 1.33A 5vooA-3hzsA:
undetectable		 5vooA-3hzsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 ASN A  87
ASP A  86
ASN A 170
ASN A 178
 None
 1.34A 5vooC-3hzsA:
undetectable		 5vooC-3hzsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 ASN A  87
ASP A  86
ASN A 170
ASN A 178
 None
 1.31A 5vooE-3hzsA:
undetectable		 5vooE-3hzsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 ASN A 268
TYR A 260
LEU A 214
SER A 243
 None
 1.40A 6a7pB-3hzsA:
undetectable		 6a7pB-3hzsA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 ALA A  95
TYR A  91
GLN A 215
ILE A 211
 None
 1.44A 6g9bA-3hzsA:
undetectable
6g9bB-3hzsA:
undetectable		 6g9bA-3hzsA:
16.75
6g9bB-3hzsA:
18.18