SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		3 / 3 VAL A 263
VAL A 310
TRP A 259
 None
 0.79A 1av2A-3hztA:
undetectable
1av2B-3hztA:
undetectable		 1av2A-3hztA:
3.29
1av2B-3hztA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.71A 1fmoE-3hztA:
21.5		 1fmoE-3hztA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 PHE A 493
GLY A 494
ILE A 484
SER A 362
LEU A 365
 None
 0.97A 1v2xA-3hztA:
undetectable		 1v2xA-3hztA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		3 / 3 VAL A 263
VAL A 310
TRP A 259
 None
 0.77A 1w5uA-3hztA:
undetectable
1w5uB-3hztA:
undetectable		 1w5uA-3hztA:
3.29
1w5uB-3hztA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 TYR A 242
MET A 180
LEU A 268
GLN A 360
PHE A 162
 None
 1.48A 1xomA-3hztA:
undetectable		 1xomA-3hztA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 TYR A 242
MET A 180
LEU A 268
GLN A 360
PHE A 162
 None
 1.48A 1xomB-3hztA:
undetectable		 1xomB-3hztA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		3 / 3 LEU A 365
LEU A 371
MET A 527
 None
 0.68A 1ya3B-3hztA:
undetectable		 1ya3B-3hztA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 5 LEU A 284
ASP A 280
VAL A 287
ILE A 283
 None
 0.91A 2aoiB-3hztA:
undetectable		 2aoiB-3hztA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.62A 2fumB-3hztA:
23.3		 2fumB-3hztA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.80A 2fumC-3hztA:
22.1		 2fumC-3hztA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.64A 2fumD-3hztA:
22.1		 2fumD-3hztA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		3 / 3 VAL A 310
TRP A 259
VAL A 263
 None
 0.68A 2izqC-3hztA:
undetectable
2izqD-3hztA:
undetectable		 2izqC-3hztA:
3.29
2izqD-3hztA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 LEU A  82
VAL A  90
LYS A 105
LEU A 206
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
 0.60A 3cs9D-3hztA:
17.7		 3cs9D-3hztA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		9 / 12 LEU A  82
GLY A  83
GLY A  88
VAL A  90
ALA A 103
LYS A 105
ASN A 204
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
GOL  A 544 (-3.4A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.74A 3eygA-3hztA:
19.4		 3eygA-3hztA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		9 / 12 LEU A  82
GLY A  83
GLY A  88
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
GOL  A 544 (-3.4A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.51A 3eygA-3hztA:
19.4		 3eygA-3hztA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		8 / 12 LEU A  82
GLY A  83
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
GOL  A 544 (-3.4A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.77A 3fupA-3hztA:
19.6		 3fupA-3hztA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		8 / 12 LEU A  82
GLY A  83
GLY A  88
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
GOL  A 544 (-3.4A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
J60  A 540 ( 3.6A)
 0.52A 3fupA-3hztA:
19.6		 3fupA-3hztA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
J60  A 540 ( 3.6A)
 0.44A 3fupB-3hztA:
19.5		 3fupB-3hztA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 11 LEU A 489
GLY A 494
ILE A 484
SER A 362
LEU A 365
 None
 1.10A 3gyqB-3hztA:
undetectable		 3gyqB-3hztA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		3 / 3 GLY A 290
PRO A 274
LEU A 314
 None
 0.48A 3hcpB-3hztA:
undetectable		 3hcpB-3hztA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 7 TYR A 149
LEU A 151
LEU A 223
THR A 115
 None
GOL  A   1 (-3.4A)
GOL  A   1 (-4.6A)
None
 0.80A 3lm8A-3hztA:
undetectable
3lm8C-3hztA:
undetectable		 3lm8A-3hztA:
18.11
3lm8C-3hztA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 7 TYR A 149
LEU A 151
LEU A 223
THR A 115
 None
GOL  A   1 (-3.4A)
GOL  A   1 (-4.6A)
None
 0.93A 3lm8B-3hztA:
undetectable
3lm8D-3hztA:
undetectable		 3lm8B-3hztA:
18.11
3lm8D-3hztA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
J60  A 540 ( 3.6A)
 0.53A 3lxkA-3hztA:
19.7		 3lxkA-3hztA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 PHE A 493
GLY A 494
ILE A 484
SER A 362
LEU A 365
 None
 0.94A 3nk7B-3hztA:
undetectable		 3nk7B-3hztA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		6 / 12 LYS A 105
LEU A 128
MET A 153
ASP A 199
ASN A 204
ASP A 220
 GOL  A   1 (-2.7A)
None
GOL  A   1 ( 3.0A)
None
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 1.47A 4an2A-3hztA:
22.0		 4an2A-3hztA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LYS A 105
LEU A 128
MET A 153
ASP A 199
LYS A 201
ASN A 204
ASP A 220
 GOL  A   1 (-2.7A)
None
GOL  A   1 ( 3.0A)
None
None
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 1.26A 4an2A-3hztA:
22.0		 4an2A-3hztA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 GLU A 203
ASP A 199
ASP A 280
GLY A 238
GLN A 360
 GOL  A 542 (-4.3A)
None
None
None
None
 1.41A 4djeB-3hztA:
undetectable		 4djeB-3hztA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 ALA A 225
LEU A 121
LEU A 151
ILE A 107
MET A 137
 GOL  A 602 (-3.2A)
None
GOL  A   1 (-3.4A)
GOL  A 544 ( 4.8A)
J60  A 540 ( 3.5A)
 1.12A 4lnxA-3hztA:
undetectable		 4lnxA-3hztA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 LEU A 161
PHE A 162
ILE A 216
ALA A 176
ILE A 267
 None
 1.03A 4nkxC-3hztA:
undetectable		 4nkxC-3hztA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 11 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.96A 4o0sA-3hztA:
23.7		 4o0sA-3hztA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 6 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LEU A 206
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.6A)
 0.51A 4o0wA-3hztA:
23.5		 4o0wA-3hztA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		3 / 3 ASP A 398
ASN A 395
SER A 451
 MG  A 601 (-2.8A)
None
None
 0.79A 4obwA-3hztA:
undetectable		 4obwA-3hztA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		6 / 8 GLY A  85
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 GOL  A 542 ( 4.8A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.75A 4ogrA-3hztA:
20.6		 4ogrA-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 7 GLY A  83
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 J60  A 540 ( 4.3A)
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.99A 4ogrE-3hztA:
20.0		 4ogrE-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		6 / 9 GLY A  85
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 GOL  A 542 ( 4.8A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.74A 4ogrI-3hztA:
20.6		 4ogrI-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		7 / 12 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.63A 4otiA-3hztA:
19.6		 4otiA-3hztA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 7 ASN A 486
GLU A 487
GLU A 488
GLU A 517
 None
 1.32A 4r87I-3hztA:
undetectable		 4r87I-3hztA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 VAL A  90
ALA A 103
LYS A 105
PHE A 221
GLY A 222
 None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 (-4.1A)
GOL  A 602 ( 3.7A)
 0.74A 4rzvB-3hztA:
22.1		 4rzvB-3hztA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 LEU A  82
VAL A  90
ILE A 136
ILE A 218
 J60  A 540 (-3.8A)
None
None
None
 0.40A 4tyjA-3hztA:
19.2		 4tyjA-3hztA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 LEU A  82
VAL A  90
LYS A 105
ILE A 136
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
None
 0.53A 4tyjA-3hztA:
19.2		 4tyjA-3hztA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		3 / 3 ASP A 253
ARG A 321
PRO A 318
 GOL  A 543 (-3.5A)
None
None
 1.08A 4wanC-3hztA:
undetectable		 4wanC-3hztA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 LYS A 108
GLY A  88
TYR A  87
ALA A  86
 GOL  A 544 (-4.5A)
GOL  A 544 (-3.4A)
None
GOL  A   1 ( 4.7A)
 1.24A 4yshB-3hztA:
undetectable		 4yshB-3hztA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 SER A 465
MET A 527
PHE A 520
GLU A 160
GLY A  83
 None
None
None
GOL  A 542 (-3.8A)
J60  A 540 ( 4.3A)
 1.45A 4zjlA-3hztA:
undetectable		 4zjlA-3hztA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 ILE A 165
PHE A 171
ARG A 168
ILE A 179
 None
 1.36A 4zzcA-3hztA:
2.3
4zzcB-3hztA:
2.3		 4zzcA-3hztA:
20.68
4zzcB-3hztA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 ILE A 165
PHE A 171
ARG A 168
ILE A 179
 None
 1.33A 4zzcB-3hztA:
2.3
4zzcC-3hztA:
2.3		 4zzcB-3hztA:
20.68
4zzcC-3hztA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 6 PRO A 274
GLU A 305
ALA A 327
LEU A 184
 None
 1.03A 5igiA-3hztA:
5.2		 5igiA-3hztA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		6 / 11 LEU A  82
GLY A  83
VAL A  90
ALA A 103
GLU A 203
LEU A 206
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A 542 (-4.3A)
GOL  A 542 ( 4.6A)
 0.60A 5lvnA-3hztA:
22.0		 5lvnA-3hztA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 8 LEU A  82
VAL A  90
LYS A 105
ASP A 220
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
J60  A 540 ( 3.6A)
 0.75A 5y9mA-3hztA:
20.1		 5y9mA-3hztA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 7 ILE A 179
GLN A 182
VAL A 183
ILE A 264
 None
 0.85A 6cduF-3hztA:
undetectable
6cduG-3hztA:
undetectable		 6cduF-3hztA:
19.60
6cduG-3hztA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		4 / 8 ILE A 179
GLN A 182
VAL A 183
ILE A 264
 None
 1.06A 6cduG-3hztA:
undetectable
6cduH-3hztA:
undetectable		 6cduG-3hztA:
19.60
6cduH-3hztA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Toxoplasma
gondii) 		5 / 12 GLY A 276
VAL A 287
GLY A 490
ASP A 280
GLN A 363
 None
 0.89A 6gngA-3hztA:
undetectable		 6gngA-3hztA:
21.41