SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 255
ARG A 246
THR A 254
 None
 0.82A 1df7A-3hzuA:
undetectable		 1df7A-3hzuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  73
MET A  82
VAL A 119
GLY A  75
 None
 1.44A 1e06B-3hzuA:
undetectable		 1e06B-3hzuA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  20
SER A 100
ASN A 101
ASP A 217
 None
 1.05A 1ig3A-3hzuA:
undetectable
1ig3B-3hzuA:
undetectable		 1ig3A-3hzuA:
23.96
1ig3B-3hzuA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 217
LEU A  20
SER A 100
ASN A 101
 None
 1.01A 1ig3A-3hzuA:
undetectable
1ig3B-3hzuA:
undetectable		 1ig3A-3hzuA:
23.96
1ig3B-3hzuA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 12 SER A 252
PHE A 256
LEU A  20
LEU A 228
LEU A 262
 None
 1.47A 1p33A-3hzuA:
undetectable		 1p33A-3hzuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 12 SER A 252
PHE A 256
LEU A  20
LEU A 228
LEU A 262
 None
 1.44A 1p33B-3hzuA:
undetectable		 1p33B-3hzuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 12 SER A 252
PHE A 256
LEU A  20
LEU A 228
LEU A 262
 None
 1.41A 1p33C-3hzuA:
undetectable		 1p33C-3hzuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 119
PHE A 114
HIS A 116
VAL A  93
 None
 1.13A 3fhxB-3hzuA:
undetectable		 3fhxB-3hzuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  97
GLY A 125
GLU A  42
ALA A 104
 None
 0.85A 3fpjB-3hzuA:
undetectable		 3fpjB-3hzuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  36
ILE A  87
HIS A 116
VAL A 119
 None
 1.19A 3nneG-3hzuA:
undetectable		 3nneG-3hzuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  31
ALA A  32
ALA A  36
ASP A  91
LEU A   3
 None
 1.38A 3ur0C-3hzuA:
undetectable		 3ur0C-3hzuA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 278
THR A 188
VAL A 165
PRO A 205
LEU A 169
 None
 1.13A 3v8vA-3hzuA:
undetectable		 3v8vA-3hzuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 126
ASP A  41
TYR A  47
 None
 0.94A 4yo9B-3hzuA:
undetectable		 4yo9B-3hzuA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 125
GLY A 220
SER A 219
LEU A 128
ARG A 221
 None
 1.29A 5hwkA-3hzuA:
undetectable		 5hwkA-3hzuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 125
GLY A 220
SER A 219
LEU A 128
ARG A 221
 None
 1.29A 5hwkB-3hzuA:
undetectable		 5hwkB-3hzuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  64
LEU A 108
VAL A 119
TYR A 148
GLY A 115
 None
 0.98A 5i8fA-3hzuA:
undetectable		 5i8fA-3hzuA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  87
GLY A  86
THR A 142
LEU A  26
LEU A  35
 None
 0.90A 5nfjA-3hzuA:
undetectable		 5nfjA-3hzuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  87
GLY A  86
THR A 142
LEU A  26
LEU A  35
 None
 0.91A 5nfjB-3hzuA:
undetectable		 5nfjB-3hzuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  87
GLY A  86
THR A 142
LEU A  26
LEU A  35
 None
 0.91A 5nfjC-3hzuA:
undetectable		 5nfjC-3hzuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 155
ARG A 159
TRP A 255
TYR A 106
 None
 1.20A 6hisB-3hzuA:
undetectable
6hisC-3hzuA:
undetectable		 6hisB-3hzuA:
15.77
6hisC-3hzuA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 155
ARG A 159
TRP A 255
TYR A 106
 None
 1.19A 6hisC-3hzuA:
undetectable
6hisD-3hzuA:
undetectable		 6hisC-3hzuA:
15.77
6hisD-3hzuA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 8 TRP A 255
TYR A 106
ASP A 155
ARG A 159
 None
 1.19A 6hisA-3hzuA:
undetectable
6hisE-3hzuA:
undetectable		 6hisA-3hzuA:
15.77
6hisE-3hzuA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 198
GLY A 197
GLY A 272
ASN A 279
 None
 0.84A 6nm4A-3hzuA:
undetectable		 6nm4A-3hzuA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 198
GLY A 197
GLY A 272
ASN A 279
ARG A 200
 None
 1.02A 6nm4B-3hzuA:
undetectable		 6nm4B-3hzuA:
20.48