SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
3 / 3 TRP M 427
VAL M 430
TRP M 418
None
1.14A 1c4dA-3i04M:
undetectable
1c4dB-3i04M:
undetectable
1c4dA-3i04M:
2.56
1c4dB-3i04M:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.18A 1c9sB-3i04A:
undetectable
1c9sC-3i04A:
undetectable
1c9sB-3i04A:
7.87
1c9sC-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 1c9sB-3i04A:
undetectable
1c9sC-3i04A:
undetectable
1c9sB-3i04A:
7.87
1c9sC-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 1c9sG-3i04A:
undetectable
1c9sH-3i04A:
undetectable
1c9sG-3i04A:
7.87
1c9sH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 1c9sG-3i04A:
undetectable
1c9sH-3i04A:
undetectable
1c9sG-3i04A:
7.87
1c9sH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 5 LEU A 107
GLU A 214
ALA A 219
LEU A 104
None
1.16A 1eta1-3i04A:
undetectable
1eta1-3i04A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 1gtfC-3i04A:
undetectable
1gtfD-3i04A:
undetectable
1gtfC-3i04A:
7.87
1gtfD-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 1gtfC-3i04A:
undetectable
1gtfD-3i04A:
undetectable
1gtfC-3i04A:
7.87
1gtfD-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.14A 1gtfG-3i04A:
undetectable
1gtfH-3i04A:
undetectable
1gtfG-3i04A:
7.87
1gtfH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.30A 1gtfG-3i04A:
undetectable
1gtfH-3i04A:
undetectable
1gtfG-3i04A:
7.87
1gtfH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.42A 1gtfP-3i04A:
undetectable
1gtfQ-3i04A:
undetectable
1gtfP-3i04A:
7.87
1gtfQ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.43A 1gtfT-3i04A:
undetectable
1gtfU-3i04A:
undetectable
1gtfT-3i04A:
7.87
1gtfU-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 GLY A 117
HIS A 113
HIS A 246
ILE A 120
ARG A 555
None
CYN  A 900 (-4.1A)
None
None
None
1.22A 1gtfU-3i04A:
undetectable
1gtfV-3i04A:
undetectable
1gtfU-3i04A:
7.87
1gtfV-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 GLY A 117
HIS A 113
THR A 249
HIS A 246
ARG A 555
None
CYN  A 900 (-4.1A)
None
None
None
1.35A 1gtfU-3i04A:
undetectable
1gtfV-3i04A:
undetectable
1gtfU-3i04A:
7.87
1gtfV-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 7 THR A 318
LEU A 323
GLY A 314
LEU A 312
None
1.02A 1gtiD-3i04A:
undetectable
1gtiD-3i04A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3001_1
(SERUM ALBUMIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 TYR A 628
LYS A 197
ARG M 117
LEU M  39
HIS A 201
None
1.37A 1hk1A-3i04A:
0.0
1hk1A-3i04A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 GLU A 533
GLY A 534
LEU A 436
LEU A 541
PRO A 542
None
1.42A 1mjqA-3i04A:
undetectable
1mjqB-3i04A:
undetectable
1mjqA-3i04A:
10.24
1mjqB-3i04A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 ASN A 284
ALA A 375
ASN A 377
None
0.65A 1n4fA-3i04A:
undetectable
1n4fA-3i04A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 8 PHE M 644
SER M 624
ALA M 603
ILE M 601
None
1.18A 1pnlA-3i04M:
undetectable
1pnlB-3i04M:
undetectable
1pnlA-3i04M:
13.53
1pnlB-3i04M:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 6 ARG A 325
ASP A 352
ASP A 376
GLU A 289
None
1.10A 1rjdA-3i04A:
undetectable
1rjdA-3i04A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 6 ARG A 325
ASP A 352
ASP A 376
GLU A 289
None
1.10A 1rjdB-3i04A:
2.4
1rjdB-3i04A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 6 ARG A 325
ASP A 352
ASP A 376
GLU A 289
None
1.06A 1rjdC-3i04A:
2.3
1rjdC-3i04A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 ALA A 397
ILE A 394
ILE A 291
PHE A 256
GLN A 293
None
1.03A 1uduB-3i04A:
undetectable
1uduB-3i04A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 GLY A 117
HIS A 113
HIS A 246
ILE A 120
ARG A 555
None
CYN  A 900 (-4.1A)
None
None
None
1.22A 1utdM-3i04A:
undetectable
1utdN-3i04A:
undetectable
1utdM-3i04A:
7.87
1utdN-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 GLY A 117
HIS A 113
THR A 249
HIS A 246
ARG A 555
None
CYN  A 900 (-4.1A)
None
None
None
1.36A 1utdM-3i04A:
undetectable
1utdN-3i04A:
undetectable
1utdM-3i04A:
7.87
1utdN-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 5 PHE A 494
LEU A 440
MET A 547
SER A 432
None
1.35A 1wrkB-3i04A:
undetectable
1wrkB-3i04A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 6 MET A 127
VAL A 125
LEU A 124
PHE A 251
None
1.18A 1x8vA-3i04A:
undetectable
1x8vA-3i04A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 ALA A 397
ILE A 394
ILE A 291
PHE A 256
GLN A 293
None
0.94A 1xozA-3i04A:
undetectable
1xozA-3i04A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 7 PRO A 575
LEU A 567
GLY A 568
LEU A 656
None
0.93A 1ya4B-3i04A:
undetectable
1ya4B-3i04A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 10 THR M 213
THR M 106
ALA M  29
ALA M 105
ALA M  36
None
1.01A 2f16K-3i04M:
undetectable
2f16L-3i04M:
undetectable
2f16K-3i04M:
14.54
2f16L-3i04M:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 10 THR M 213
THR M 106
ALA M  29
ALA M 105
ALA M  36
None
1.01A 2f16Y-3i04M:
undetectable
2f16Z-3i04M:
undetectable
2f16Y-3i04M:
14.54
2f16Z-3i04M:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 6 TYR M 221
TYR M 207
GLY M 137
ASP M 138
None
1.27A 2g72A-3i04M:
undetectable
2g72A-3i04M:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 12 VAL M 198
LEU M 200
ILE M 185
ILE M 159
ALA M 157
None
1.07A 2gj5A-3i04M:
undetectable
2gj5A-3i04M:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 SER A 264
ASN A 277
THR A 343
VAL A 279
VAL A 322
None
1.26A 2nniA-3i04A:
0.0
2nniA-3i04A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 4 SER A 211
GLY A 207
HIS A 113
ASP A 552
None
None
CYN  A 900 (-4.1A)
None
1.18A 2oxtC-3i04A:
2.7
2oxtC-3i04A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 LEU A 541
PRO A 542
LEU A 528
None
0.58A 2po7B-3i04A:
3.5
2po7B-3i04A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 VAL A 292
ILE A 328
GLY A 314
ILE A 315
ILE A 291
None
0.89A 2pymB-3i04A:
undetectable
2pymB-3i04A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 369
THR A 332
VAL A 313
ILE A 315
VAL A 331
None
1.45A 2qboA-3i04A:
undetectable
2qboA-3i04A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLY A 469
GLY A 109
GLY A 586
THR A 108
LEU A 107
XCC  A 800 (-3.6A)
None
None
None
None
0.98A 2wa2B-3i04A:
2.7
2wa2B-3i04A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 12 VAL M 149
SER M 539
VAL M 531
GLY M 526
ALA M 530
None
None
SF4  M 900 ( 4.3A)
SF4  M 900 (-3.6A)
None
1.23A 2x2iC-3i04M:
undetectable
2x2iC-3i04M:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 5 ALA A 588
GLY A 499
CYH A 550
HIS A 113
CYN  A 900 ( 4.8A)
XCC  A 800 ( 4.1A)
XCC  A 800 ( 2.1A)
CYN  A 900 (-4.1A)
1.45A 2ylgA-3i04A:
undetectable
2ylgA-3i04A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 VAL A 557
VAL A 574
GLY A 599
ILE A 190
ALA A 564
None
0.87A 2z0yA-3i04A:
5.3
2z0yA-3i04A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 VAL A 557
VAL A 574
GLY A 599
ILE A 190
ALA A 564
None
0.77A 2z0yB-3i04A:
4.4
2z0yB-3i04A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 7 ARG A 411
GLU A 410
ALA A 307
ALA A 305
None
1.11A 2zgwA-3i04A:
undetectable
2zgwA-3i04A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 8 THR A 258
ASP A 552
GLU A 289
SER A 252
None
1.06A 2zw9A-3i04A:
2.6
2zw9A-3i04A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 5 SER A 549
LEU A 280
GLY A 282
GLU A 321
None
1.16A 3aiaA-3i04A:
1.4
3aiaB-3i04A:
2.9
3aiaA-3i04A:
15.19
3aiaB-3i04A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica)
4 / 8 ARG A 194
TYR A 674
GLN M  42
GLU M  37
None
1.37A 3dh0A-3i04A:
2.7
3dh0A-3i04A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 5 ASP A 570
ILE A 190
VAL A 557
THR A 602
None
0.92A 3eigA-3i04A:
undetectable
3eigA-3i04A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 VAL A 292
ILE A 328
GLY A 314
ILE A 315
ILE A 291
None
0.93A 3el0B-3i04A:
undetectable
3el0B-3i04A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica)
5 / 12 THR A 593
VAL A 228
TYR A 674
SER A 625
ILE M 113
None
1.36A 3frqA-3i04A:
undetectable
3frqA-3i04A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 LEU A 541
PRO A 542
LEU A 528
None
0.55A 3hcrA-3i04A:
3.8
3hcrA-3i04A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 8 ILE A 386
ALA A 400
LEU A 287
ALA A 294
None
0.90A 3hrdA-3i04A:
undetectable
3hrdB-3i04A:
undetectable
3hrdA-3i04A:
22.44
3hrdB-3i04A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica)
3 / 3 ASN A 202
ASN A 229
GLU M  37
None
0.80A 3kpdC-3i04A:
undetectable
3kpdC-3i04A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica)
3 / 3 ASN A 202
ASN A 229
GLU M  37
None
0.74A 3kpdB-3i04A:
undetectable
3kpdB-3i04A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica)
3 / 3 SER M  34
ASP A 226
ASN A 225
None
0.98A 3lsfB-3i04M:
undetectable
3lsfE-3i04M:
undetectable
3lsfB-3i04M:
18.31
3lsfE-3i04M:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica)
3 / 3 ASP A 226
ASN A 225
SER M  34
None
0.94A 3lsfB-3i04A:
undetectable
3lsfE-3i04A:
undetectable
3lsfB-3i04A:
17.23
3lsfE-3i04A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ILE A 212
ALA A 234
THR A 593
ALA A 589
ALA A 110
None
1.09A 3mdtB-3i04A:
undetectable
3mdtB-3i04A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 LEU A 330
GLY A 499
ALA A 502
ALA A 505
LEU A 511
None
XCC  A 800 ( 4.1A)
None
None
None
1.09A 3p5nA-3i04A:
undetectable
3p5nA-3i04A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 LEU A 330
GLY A 499
ALA A 502
ALA A 505
LEU A 511
None
XCC  A 800 ( 4.1A)
None
None
None
1.09A 3p5nB-3i04A:
undetectable
3p5nB-3i04A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 7 ILE M 667
SER M 654
TYR M 651
ARG M 685
None
0.99A 3pglA-3i04M:
4.0
3pglA-3i04M:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 THR A 189
ASP A 250
GLU A 434
None
0.74A 3qowA-3i04A:
undetectable
3qowA-3i04A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 5 ARG M  66
PRO M  63
TYR M  61
VAL M  64
None
1.08A 3sufC-3i04M:
undetectable
3sufC-3i04M:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 9 PHE M   8
PHE M  96
ILE M 270
GLY M 268
PHE M   4
None
1.39A 3t3rB-3i04M:
undetectable
3t3rB-3i04M:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 9 PHE M   8
PHE M  96
ILE M 270
GLY M 268
PHE M   4
None
1.37A 3t3rC-3i04M:
undetectable
3t3rC-3i04M:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ILE A 380
ILE A 341
ALA A 383
VAL A 351
VAL A 279
None
0.86A 3tmzA-3i04A:
undetectable
3tmzA-3i04A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 8 VAL M  53
LEU M 119
LEU M 116
ILE M  44
None
0.93A 3u5kD-3i04M:
undetectable
3u5kD-3i04M:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 8 PHE A 527
GLY A 526
GLY A 463
ASN A 453
None
0.92A 3v3nB-3i04A:
3.2
3v3nB-3i04A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 8 PHE A 527
GLY A 526
GLY A 463
ASN A 453
None
0.92A 3v3nC-3i04A:
3.3
3v3nC-3i04A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_A_ACTA511_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 4 ASN A 471
PHE A 334
SER A 333
GLN A 337
None
XCC  A 800 (-4.2A)
None
None
1.37A 3v5vA-3i04A:
0.0
3v5vA-3i04A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 TYR A 242
ASP A 558
ASP A 552
None
0.75A 4a6eA-3i04A:
undetectable
4a6eA-3i04A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 8 ASN M 211
ASP M 187
VAL M 190
LEU M 128
None
1.09A 4f8hB-3i04M:
undetectable
4f8hC-3i04M:
undetectable
4f8hB-3i04M:
17.97
4f8hC-3i04M:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 PHE A 198
ILE A 235
GLY A 630
GLY A 629
TYR A 674
None
1.39A 4fglA-3i04A:
4.7
4fglB-3i04A:
3.6
4fglA-3i04A:
15.01
4fglB-3i04A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 HIS A   9
GLU M 188
LEU M 169
ASP M 279
GLY M 256
None
1.39A 4foxC-3i04A:
undetectable
4foxC-3i04A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 HIS A   9
GLU M 188
LEU M 169
ASP M 279
GLY M 256
None
1.37A 4foxF-3i04A:
undetectable
4foxF-3i04A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 7 ILE M 311
LEU M 313
LYS M 147
GLY M 325
None
1.00A 4hajA-3i04M:
undetectable
4hajA-3i04M:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.14A 4hvcA-3i04A:
undetectable
4hvcA-3i04A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.13A 4hvcB-3i04A:
undetectable
4hvcB-3i04A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
3 / 3 ASP M 497
ARG M 685
THR M 521
None
0.89A 4i13A-3i04M:
undetectable
4i13A-3i04M:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 8 PRO A  13
VAL A 604
GLY A 605
MET A 636
None
0.99A 4klrB-3i04A:
4.0
4klrB-3i04A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 7 MET A 324
PRO A 285
SER A 288
VAL A 551
None
1.29A 4kmmA-3i04A:
undetectable
4kmmA-3i04A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 9 ASP M  78
GLY M  54
PRO M  63
VAL M  64
ILE M  65
None
1.20A 4ll3B-3i04M:
undetectable
4ll3B-3i04M:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 12 ILE M 159
ALA M 163
LEU M 194
LEU M 200
ILE M 185
None
1.00A 4m2xA-3i04M:
undetectable
4m2xA-3i04M:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 12 ILE M 159
ALA M 163
LEU M 194
LEU M 200
ILE M 185
None
1.01A 4m2xC-3i04M:
undetectable
4m2xC-3i04M:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 12 ILE M 159
ALA M 163
LEU M 194
LEU M 200
ILE M 185
None
1.01A 4m2xE-3i04M:
2.0
4m2xE-3i04M:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB304_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 4 GLY A 599
SER A 597
ARG A 194
PRO A 572
None
1.41A 4m93B-3i04A:
0.0
4m93C-3i04A:
undetectable
4m93B-3i04A:
16.10
4m93C-3i04A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica)
3 / 3 ARG M 162
GLU M 191
ARG A   5
None
0.90A 4mwvA-3i04M:
undetectable
4mwvA-3i04M:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLY A  85
PRO A  84
GLY A  83
ILE A  97
GLY A  91
None
1.15A 4n48A-3i04A:
3.0
4n48A-3i04A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
3 / 3 ALA M  36
GLN M 214
GLY M 210
None
0.57A 4odoC-3i04M:
undetectable
4odoC-3i04M:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.11A 4olfA-3i04A:
4.6
4olfA-3i04A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
3 / 3 ASP M 497
ARG M 685
THR M 521
None
0.87A 4p3rA-3i04M:
2.4
4p3rA-3i04M:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.10A 4q15A-3i04A:
4.3
4q15A-3i04A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.11A 4q15B-3i04A:
4.9
4q15B-3i04A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
6 / 9 ALA M 109
SER A 618
ILE A 623
GLY M  28
ALA M  29
VAL A 228
None
1.20A 4r1zA-3i04M:
1.2
4r1zA-3i04M:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 6 ASN M 220
GLU M 114
TYR M 108
GLU M 111
None
1.42A 4r87H-3i04M:
undetectable
4r87H-3i04M:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 ASP A 226
SER M  34
ALA M 102
ALA M 105
TYR M  26
None
1.38A 4u15B-3i04A:
undetectable
4u15B-3i04A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
3 / 3 ASP M 203
ARG M 649
ARG M 616
None
0.94A 4x5iA-3i04M:
undetectable
4x5iA-3i04M:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.12A 4ydqA-3i04A:
5.3
4ydqA-3i04A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.13A 4ydqB-3i04A:
5.0
4ydqB-3i04A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
THR A 606
SER A 480
GLY A 475
None
1.36A 4ydqB-3i04A:
5.0
4ydqB-3i04A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 SER A 333
LEU A 323
ASN A 553
GLU A 245
MET A 324
None
1.29A 4zjlD-3i04A:
0.4
4zjlD-3i04A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 ASP A 226
SER M  34
ALA M 102
ALA M 105
TYR M  26
None
1.39A 5cxvA-3i04A:
0.5
5cxvA-3i04A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
3 / 3 ARG M 406
LYS M 451
GLU M 455
None
0.81A 5d0yA-3i04M:
undetectable
5d0yA-3i04M:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 5 GLU M 114
ALA M 115
GLU M 111
ASN M 220
None
1.02A 5dwkC-3i04M:
undetectable
5dwkC-3i04M:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
3 / 3 ASP M 203
ARG M 649
ARG M 616
None
0.97A 5eajB-3i04M:
undetectable
5eajB-3i04M:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 8 ILE A 235
VAL A 627
TYR A 628
VAL A 231
None
0.90A 5ecnD-3i04A:
undetectable
5ecnD-3i04A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.18A 5eeuD-3i04A:
undetectable
5eeuE-3i04A:
undetectable
5eeuD-3i04A:
7.87
5eeuE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.30A 5eeuD-3i04A:
undetectable
5eeuE-3i04A:
undetectable
5eeuD-3i04A:
7.87
5eeuE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.47A 5eeuG-3i04A:
undetectable
5eeuH-3i04A:
undetectable
5eeuG-3i04A:
7.87
5eeuH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5eeuH-3i04A:
undetectable
5eeuI-3i04A:
undetectable
5eeuH-3i04A:
7.87
5eeuI-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.43A 5eeuP-3i04A:
undetectable
5eeuQ-3i04A:
undetectable
5eeuP-3i04A:
7.87
5eeuQ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.43A 5eeuU-3i04A:
undetectable
5eeuV-3i04A:
undetectable
5eeuU-3i04A:
7.87
5eeuV-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 5eevD-3i04A:
undetectable
5eevE-3i04A:
undetectable
5eevD-3i04A:
7.87
5eevE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.30A 5eevD-3i04A:
undetectable
5eevE-3i04A:
undetectable
5eevD-3i04A:
7.87
5eevE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.48A 5eevE-3i04A:
undetectable
5eevF-3i04A:
undetectable
5eevE-3i04A:
7.87
5eevF-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.46A 5eevG-3i04A:
undetectable
5eevH-3i04A:
undetectable
5eevG-3i04A:
7.87
5eevH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.43A 5eevP-3i04A:
undetectable
5eevQ-3i04A:
undetectable
5eevP-3i04A:
7.87
5eevQ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.42A 5eevU-3i04A:
undetectable
5eevV-3i04A:
undetectable
5eevU-3i04A:
7.87
5eevV-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.18A 5eewD-3i04A:
undetectable
5eewE-3i04A:
undetectable
5eewD-3i04A:
7.87
5eewE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.31A 5eewD-3i04A:
undetectable
5eewE-3i04A:
undetectable
5eewD-3i04A:
7.87
5eewE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.48A 5eewE-3i04A:
undetectable
5eewF-3i04A:
undetectable
5eewE-3i04A:
7.87
5eewF-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.47A 5eewG-3i04A:
undetectable
5eewH-3i04A:
undetectable
5eewG-3i04A:
7.87
5eewH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5eewH-3i04A:
undetectable
5eewI-3i04A:
undetectable
5eewH-3i04A:
7.87
5eewI-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.43A 5eewP-3i04A:
undetectable
5eewQ-3i04A:
undetectable
5eewP-3i04A:
7.87
5eewQ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.41A 5eewU-3i04A:
undetectable
5eewV-3i04A:
undetectable
5eewU-3i04A:
7.87
5eewV-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 5eexD-3i04A:
undetectable
5eexE-3i04A:
undetectable
5eexD-3i04A:
7.87
5eexE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.31A 5eexD-3i04A:
undetectable
5eexE-3i04A:
undetectable
5eexD-3i04A:
7.87
5eexE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.48A 5eexE-3i04A:
undetectable
5eexF-3i04A:
undetectable
5eexE-3i04A:
7.87
5eexF-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.46A 5eexG-3i04A:
undetectable
5eexH-3i04A:
undetectable
5eexG-3i04A:
7.87
5eexH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.18A 5eexH-3i04A:
undetectable
5eexI-3i04A:
undetectable
5eexH-3i04A:
7.87
5eexI-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5eexI-3i04A:
undetectable
5eexJ-3i04A:
undetectable
5eexI-3i04A:
7.87
5eexJ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 5eexI-3i04A:
undetectable
5eexJ-3i04A:
undetectable
5eexI-3i04A:
7.87
5eexJ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.43A 5eexP-3i04A:
undetectable
5eexQ-3i04A:
undetectable
5eexP-3i04A:
7.87
5eexQ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.42A 5eexU-3i04A:
undetectable
5eexV-3i04A:
undetectable
5eexU-3i04A:
7.87
5eexV-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 5eeyD-3i04A:
undetectable
5eeyE-3i04A:
undetectable
5eeyD-3i04A:
7.87
5eeyE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.31A 5eeyD-3i04A:
undetectable
5eeyE-3i04A:
undetectable
5eeyD-3i04A:
7.87
5eeyE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.47A 5eeyE-3i04A:
undetectable
5eeyF-3i04A:
undetectable
5eeyE-3i04A:
7.87
5eeyF-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.46A 5eeyG-3i04A:
undetectable
5eeyH-3i04A:
undetectable
5eeyG-3i04A:
7.87
5eeyH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5eeyI-3i04A:
undetectable
5eeyJ-3i04A:
undetectable
5eeyI-3i04A:
7.87
5eeyJ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 5eeyI-3i04A:
undetectable
5eeyJ-3i04A:
undetectable
5eeyI-3i04A:
7.87
5eeyJ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.43A 5eeyP-3i04A:
undetectable
5eeyQ-3i04A:
undetectable
5eeyP-3i04A:
7.87
5eeyQ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 5eezD-3i04A:
undetectable
5eezE-3i04A:
undetectable
5eezD-3i04A:
7.87
5eezE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.30A 5eezD-3i04A:
undetectable
5eezE-3i04A:
undetectable
5eezD-3i04A:
7.87
5eezE-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.47A 5eezE-3i04A:
undetectable
5eezF-3i04A:
undetectable
5eezE-3i04A:
7.87
5eezF-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.46A 5eezG-3i04A:
undetectable
5eezH-3i04A:
undetectable
5eezG-3i04A:
7.87
5eezH-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5eezI-3i04A:
undetectable
5eezJ-3i04A:
undetectable
5eezI-3i04A:
7.87
5eezJ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 5eezI-3i04A:
undetectable
5eezJ-3i04A:
undetectable
5eezI-3i04A:
7.87
5eezJ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.43A 5eezP-3i04A:
undetectable
5eezQ-3i04A:
undetectable
5eezP-3i04A:
7.87
5eezQ-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.41A 5eezU-3i04A:
undetectable
5eezV-3i04A:
undetectable
5eezU-3i04A:
7.87
5eezV-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 5ef0D-3i04A:
undetectable
5ef0E-3i04A:
undetectable
5ef0D-3i04A:
7.87
5ef0E-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.31A 5ef0D-3i04A:
undetectable
5ef0E-3i04A:
undetectable
5ef0D-3i04A:
7.87
5ef0E-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.47A 5ef0E-3i04A:
undetectable
5ef0F-3i04A:
undetectable
5ef0E-3i04A:
7.87
5ef0F-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.46A 5ef0G-3i04A:
undetectable
5ef0H-3i04A:
undetectable
5ef0G-3i04A:
7.87
5ef0H-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5ef0I-3i04A:
undetectable
5ef0J-3i04A:
undetectable
5ef0I-3i04A:
7.87
5ef0J-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 5ef0I-3i04A:
undetectable
5ef0J-3i04A:
undetectable
5ef0I-3i04A:
7.87
5ef0J-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.42A 5ef0P-3i04A:
undetectable
5ef0Q-3i04A:
undetectable
5ef0P-3i04A:
7.87
5ef0Q-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.41A 5ef0U-3i04A:
undetectable
5ef0V-3i04A:
undetectable
5ef0U-3i04A:
7.87
5ef0V-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 5ef1D-3i04A:
undetectable
5ef1E-3i04A:
undetectable
5ef1D-3i04A:
7.87
5ef1E-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.31A 5ef1D-3i04A:
undetectable
5ef1E-3i04A:
undetectable
5ef1D-3i04A:
7.87
5ef1E-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.47A 5ef1E-3i04A:
undetectable
5ef1F-3i04A:
undetectable
5ef1E-3i04A:
7.87
5ef1F-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.45A 5ef1G-3i04A:
undetectable
5ef1H-3i04A:
undetectable
5ef1G-3i04A:
7.87
5ef1H-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5ef1I-3i04A:
undetectable
5ef1J-3i04A:
undetectable
5ef1I-3i04A:
7.87
5ef1J-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 5ef1I-3i04A:
undetectable
5ef1J-3i04A:
undetectable
5ef1I-3i04A:
7.87
5ef1J-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.41A 5ef1N-3i04A:
undetectable
5ef1O-3i04A:
undetectable
5ef1N-3i04A:
7.87
5ef1O-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.42A 5ef1P-3i04A:
undetectable
5ef1Q-3i04A:
undetectable
5ef1P-3i04A:
7.87
5ef1Q-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.41A 5ef1U-3i04A:
undetectable
5ef1V-3i04A:
undetectable
5ef1U-3i04A:
7.87
5ef1V-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 5ef2D-3i04A:
undetectable
5ef2E-3i04A:
undetectable
5ef2D-3i04A:
7.87
5ef2E-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.31A 5ef2D-3i04A:
undetectable
5ef2E-3i04A:
undetectable
5ef2D-3i04A:
7.87
5ef2E-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.47A 5ef2E-3i04A:
undetectable
5ef2F-3i04A:
undetectable
5ef2E-3i04A:
7.87
5ef2F-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.45A 5ef2G-3i04A:
undetectable
5ef2H-3i04A:
undetectable
5ef2G-3i04A:
7.87
5ef2H-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5ef2I-3i04A:
undetectable
5ef2J-3i04A:
undetectable
5ef2I-3i04A:
7.87
5ef2J-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 5ef2I-3i04A:
undetectable
5ef2J-3i04A:
undetectable
5ef2I-3i04A:
7.87
5ef2J-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.41A 5ef2N-3i04A:
undetectable
5ef2O-3i04A:
undetectable
5ef2N-3i04A:
7.87
5ef2O-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.42A 5ef2P-3i04A:
undetectable
5ef2Q-3i04A:
undetectable
5ef2P-3i04A:
7.87
5ef2Q-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.41A 5ef2U-3i04A:
undetectable
5ef2V-3i04A:
undetectable
5ef2U-3i04A:
7.87
5ef2V-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.17A 5ef3D-3i04A:
undetectable
5ef3E-3i04A:
undetectable
5ef3D-3i04A:
7.87
5ef3E-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.30A 5ef3D-3i04A:
undetectable
5ef3E-3i04A:
undetectable
5ef3D-3i04A:
7.87
5ef3E-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 9 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.47A 5ef3E-3i04A:
undetectable
5ef3F-3i04A:
undetectable
5ef3E-3i04A:
7.87
5ef3F-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 THR A 189
GLY A 244
HIS A 246
ALA A 183
ILE A 208
None
1.45A 5ef3G-3i04A:
undetectable
5ef3H-3i04A:
undetectable
5ef3G-3i04A:
7.87
5ef3H-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
HIS A 246
ILE A 120
None
None
CYN  A 900 (-4.1A)
None
None
1.19A 5ef3I-3i04A:
undetectable
5ef3J-3i04A:
undetectable
5ef3I-3i04A:
7.87
5ef3J-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 ARG A 555
GLY A 117
HIS A 113
THR A 249
HIS A 246
None
None
CYN  A 900 (-4.1A)
None
None
1.32A 5ef3I-3i04A:
undetectable
5ef3J-3i04A:
undetectable
5ef3I-3i04A:
7.87
5ef3J-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.41A 5ef3N-3i04A:
undetectable
5ef3O-3i04A:
undetectable
5ef3N-3i04A:
7.87
5ef3O-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.42A 5ef3P-3i04A:
undetectable
5ef3Q-3i04A:
undetectable
5ef3P-3i04A:
7.87
5ef3Q-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 GLY A 244
HIS A 246
ALA A 183
ILE A 208
THR A 189
None
1.40A 5ef3U-3i04A:
undetectable
5ef3V-3i04A:
undetectable
5ef3U-3i04A:
7.87
5ef3V-3i04A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.08A 5f9zA-3i04A:
3.6
5f9zA-3i04A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.10A 5f9zB-3i04A:
4.5
5f9zB-3i04A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 THR A 189
ASP A 250
GLU A 434
None
0.80A 5fa8A-3i04A:
undetectable
5fa8A-3i04A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 ALA A 590
GLY A 592
ALA A 110
GLY A 586
SER A 585
None
None
None
None
XCC  A 800 (-2.9A)
1.36A 5jglB-3i04A:
undetectable
5jglB-3i04A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 5 ALA A 588
GLY A 499
CYH A 550
HIS A 113
CYN  A 900 ( 4.8A)
XCC  A 800 ( 4.1A)
XCC  A 800 ( 2.1A)
CYN  A 900 (-4.1A)
1.45A 5jliA-3i04A:
undetectable
5jliA-3i04A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 ARG A 175
ILE A 208
PHE A 174
None
0.61A 5kirA-3i04A:
undetectable
5kirA-3i04A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 9 THR M 213
THR M 106
ALA M  29
ALA M 105
ALA M  36
None
1.03A 5l5zK-3i04M:
undetectable
5l5zL-3i04M:
undetectable
5l5zK-3i04M:
16.74
5l5zL-3i04M:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 9 THR M 213
THR M 106
ALA M  29
ALA M 105
ALA M  36
None
1.03A 5l5zY-3i04M:
undetectable
5l5zZ-3i04M:
undetectable
5l5zY-3i04M:
16.74
5l5zZ-3i04M:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 PHE A 198
ILE A 235
GLY A 630
GLY A 629
TYR A 674
None
1.37A 5lbtA-3i04A:
4.8
5lbtB-3i04A:
4.7
5lbtA-3i04A:
16.98
5lbtB-3i04A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 10 GLY M 663
GLY M 662
PHE M 682
ILE M 667
PHE M 695
None
1.48A 5lbtA-3i04M:
3.0
5lbtB-3i04M:
2.9
5lbtA-3i04M:
14.56
5lbtB-3i04M:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 12 PHE M 251
ALA M 305
ILE M 311
PHE M 181
ILE M 301
None
1.01A 5m24A-3i04M:
undetectable
5m24A-3i04M:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
5 / 12 ILE M 215
ILE M 301
VAL M 173
LEU M 176
VAL M 302
None
1.02A 5mugA-3i04M:
undetectable
5mugA-3i04M:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLY A 244
HIS A 246
ILE A 106
ALA A 590
VAL A 237
None
1.08A 5n0tA-3i04A:
3.0
5n0tA-3i04A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLY A 244
HIS A 246
ILE A 106
ALA A 590
VAL A 237
None
1.07A 5n0wB-3i04A:
3.1
5n0wB-3i04A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLY A 244
HIS A 246
ILE A 106
ALA A 590
VAL A 237
None
1.09A 5n0xA-3i04A:
undetectable
5n0xA-3i04A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLY A 244
HIS A 246
ILE A 106
ALA A 590
VAL A 237
None
1.07A 5n4iA-3i04A:
undetectable
5n4iA-3i04A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 6 ARG A 236
ALA A 240
PRO A 205
PHE A 206
None
1.39A 5odqA-3i04A:
4.4
5odqA-3i04A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 8 PHE A  49
GLN A 477
MET A 357
THR A 332
None
1.30A 5u6nA-3i04A:
6.0
5u6nA-3i04A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 ASP A 347
ASN A 277
ASP A 272
None
0.83A 5vopA-3i04A:
undetectable
5vopA-3i04A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 ASP A 347
ASN A 277
ASP A 272
None
0.85A 5vopB-3i04A:
undetectable
5vopB-3i04A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 5 TYR A 242
ASP A 558
ASP A 552
ARG A 148
None
0.94A 5w7pA-3i04A:
2.0
5w7pA-3i04A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 VAL A 331
GLY A 314
ALA A 340
LEU A 271
ASN A 311
None
1.21A 5x6yA-3i04A:
4.6
5x6yA-3i04A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 VAL A 331
GLY A 314
ALA A 340
LEU A 271
ASN A 311
None
1.23A 5x6yC-3i04A:
2.2
5x6yC-3i04A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica)
4 / 6 HIS M 516
ASN M 548
LEU M 571
GLN M 549
SF4  M 900 ( 4.8A)
None
None
None
1.49A 5xdhA-3i04M:
undetectable
5xdhC-3i04M:
undetectable
5xdhA-3i04M:
7.27
5xdhC-3i04M:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.17A 5xipA-3i04A:
4.3
5xipA-3i04A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.08A 5xiqA-3i04A:
4.5
5xiqA-3i04A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
THR A 606
SER A 480
None
1.42A 5xiqC-3i04A:
4.8
5xiqC-3i04A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 GLN A 389
ILE A 356
HIS A 281
None
0.71A 5z12B-3i04A:
undetectable
5z12B-3i04A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 MET A 561
ASP A 570
ARG A 199
None
0.97A 5z6jA-3i04A:
undetectable
5z6jA-3i04A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
3 / 3 MET A 561
ASP A 570
ARG A 199
None
1.09A 5z6kA-3i04A:
undetectable
5z6kA-3i04A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 10 PHE A 174
LEU A 171
GLY A 207
ILE A 208
ILE A 247
None
0.99A 6ebpD-3i04A:
undetectable
6ebpD-3i04A:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 PHE A 174
LEU A 171
GLY A 207
ILE A 208
ILE A 247
None
0.92A 6ebzA-3i04A:
undetectable
6ebzA-3i04A:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 PHE A 174
LEU A 171
GLY A 207
ILE A 208
ILE A 247
None
0.95A 6ebzB-3i04A:
undetectable
6ebzB-3i04A:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 PHE A 174
LEU A 171
GLY A 207
ILE A 208
ILE A 247
None
0.96A 6ebzC-3i04A:
undetectable
6ebzC-3i04A:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 PHE A 174
LEU A 171
GLY A 207
ILE A 208
ILE A 247
None
0.98A 6ebzD-3i04A:
undetectable
6ebzD-3i04A:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 6 PHE A 174
LEU A 171
ALA A 170
ASN A 284
None
1.02A 6f88A-3i04A:
0.2
6f88A-3i04A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
4 / 8 VAL A 231
HIS A 201
ASN A 202
GLU M  37
None
1.32A 6gneB-3i04A:
7.2
6gneB-3i04A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 PHE A 174
LEU A 171
GLY A 207
ILE A 208
ILE A 247
None
0.95A 6gp2A-3i04A:
undetectable
6gp2A-3i04A:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 11 PHE A 174
LEU A 171
GLY A 207
ILE A 208
ILE A 247
None
0.96A 6gp2B-3i04A:
undetectable
6gp2B-3i04A:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica)
5 / 12 GLU A 611
VAL A 610
PRO A 608
SER A 480
GLY A 475
None
1.15A 6mn8A-3i04A:
4.0
6mn8A-3i04A:
20.33