SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 HIS A  47
PHE A  94
LEU A  91
ILE A  92
 None
 1.17A 1sbrA-3i05A:
undetectable
1sbrB-3i05A:
undetectable		 1sbrA-3i05A:
20.82
1sbrB-3i05A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 ASP A 115
MET A 112
ASP A 114
ASP A 154
 None
 1.47A 1t03A-3i05A:
undetectable		 1t03A-3i05A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 ILE A 168
VAL A 165
ILE A 110
ILE A 136
 None
 0.79A 1uwhA-3i05A:
undetectable		 1uwhA-3i05A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 ILE A 168
VAL A 165
ILE A 110
ILE A 136
 None
 0.80A 1uwhB-3i05A:
undetectable		 1uwhB-3i05A:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 12 TYR A  76
THR A  77
GLY A  78
GLY A  80
THR A 113
GLN A 198
ILE A 222
 None
 0.37A 2akeA-3i05A:
42.3		 2akeA-3i05A:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 12 TYR A  76
THR A  77
GLY A  78
GLY A  80
THR A 113
GLU A 116
GLN A 198
 None
 0.52A 2akeA-3i05A:
42.3		 2akeA-3i05A:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		9 / 12 TYR A  76
THR A  77
GLY A  78
GLY A  80
GLN A 111
THR A 113
GLU A 116
GLN A 198
ILE A 222
 None
 0.53A 2azxA-3i05A:
42.2		 2azxA-3i05A:
46.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		9 / 12 TYR A  76
THR A  77
GLY A  78
GLY A  80
GLN A 111
THR A 113
GLU A 116
GLN A 198
ILE A 222
 None
 0.60A 2azxB-3i05A:
42.3		 2azxB-3i05A:
46.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 11 TYR A  76
GLY A  78
GLY A  80
GLN A 111
THR A 113
GLN A 198
ILE A 222
 None
 0.41A 2dr2A-3i05A:
41.9		 2dr2A-3i05A:
54.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 11 TYR A  76
GLY A  78
GLY A  80
GLN A 111
THR A 113
GLU A 116
GLN A 198
 None
 0.56A 2dr2A-3i05A:
41.9		 2dr2A-3i05A:
54.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 9 GLN A 101
PHE A 144
GLY A 143
ILE A 140
PHE A 152
 None
 1.49A 2dr6A-3i05A:
0.0		 2dr6A-3i05A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 PHE A 219
ILE A 250
PHE A  54
ALA A 248
ILE A  29
 None
 1.32A 3ndiA-3i05A:
undetectable		 3ndiA-3i05A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 ILE A 123
PRO A 124
PHE A 118
PHE A 155
 None
 1.19A 4fgkA-3i05A:
undetectable		 4fgkA-3i05A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 VAL A 106
ARG A  58
PRO A 247
 None
 0.65A 5koxA-3i05A:
undetectable		 5koxA-3i05A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3i05 TRYPTOPHANYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 HIS A  87
HIS A  90
ARG A  79
 None
 0.85A 6b58A-3i05A:
undetectable		 6b58A-3i05A:
19.40