SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PHE A1484
LEU A1516
ALA B1702
PHE B1694
GLY A1514
 None
 1.28A 1kglA-3i08A:
undetectable		 1kglA-3i08A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Homo
sapiens) 		5 / 9 GLY B1711
ALA B1708
SER B1712
LEU B1713
LEU B1704
 None
 1.42A 1y7iA-3i08B:
undetectable		 1y7iA-3i08B:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A1520
PHE A1501
ALA B1706
ALA B1702
THR B1698
 None
 1.30A 2x2nD-3i08A:
undetectable		 2x2nD-3i08A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE B1719
ASN A1485
LEU B1713
VAL A1605
LEU A1575
 None
 1.09A 3a51A-3i08B:
undetectable		 3a51A-3i08B:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Homo
sapiens) 		4 / 5 ARG A1595
ASP A1543
ASP A1558
ASP A1547
 None
CA  A1667 (-2.8A)
CA  A1667 (-2.1A)
CA  A1667 (-3.3A)
 1.15A 3naiC-3i08A:
undetectable		 3naiC-3i08A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Homo
sapiens) 		5 / 9 ASN A1485
GLY A1477
GLY A1478
GLY A1474
ASP A1486
 None
None
None
None
CL  A1668 (-4.5A)
 1.48A 4h2fA-3i08A:
undetectable		 4h2fA-3i08A:
18.26