SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE A  52
GLY A 137
ILE A 138
VAL A 191
ILE A  17
 None
 0.89A 1sdtA-3i0mA:
undetectable		 1sdtA-3i0mA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 150
ASP A 177
ASN A 211
 GOL  A 325 (-4.6A)
None
None
 0.78A 1wg8B-3i0mA:
undetectable		 1wg8B-3i0mA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 9 ILE A  52
GLY A 137
ILE A 138
VAL A 191
ILE A  17
 None
 0.85A 2avoA-3i0mA:
undetectable		 2avoA-3i0mA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 11 MET A 233
LEU A 226
LEU A 243
ILE A 310
THR A 236
 None
 1.23A 2qd3A-3i0mA:
undetectable		 2qd3A-3i0mA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 184
CYH A 204
ILE A 208
VAL A 152
ILE A 118
 None
 1.22A 2uxoB-3i0mA:
undetectable		 2uxoB-3i0mA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A 164
THR A 165
GLU A 239
ALA A 168
 None
 0.63A 3aruA-3i0mA:
undetectable		 3aruA-3i0mA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 9 ILE A  52
GLY A 137
ILE A 138
VAL A 191
ILE A  17
 None
 0.97A 3d1yB-3i0mA:
undetectable		 3d1yB-3i0mA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A  52
GLY A 137
ILE A 138
VAL A 191
ILE A  17
 None
 0.89A 3k4vC-3i0mA:
undetectable		 3k4vC-3i0mA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		3 / 3 GLN A 156
THR A 162
ASN A 154
 None
 0.90A 3v4tE-3i0mA:
undetectable		 3v4tE-3i0mA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS A 171
THR A 173
ILE A 118
 None
 0.85A 4e0fB-3i0mA:
undetectable		 4e0fB-3i0mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 12 MET A 233
LEU A 226
LEU A 243
ILE A 310
THR A 236
 None
 1.27A 4f4dA-3i0mA:
undetectable		 4f4dA-3i0mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  98
ILE A 100
LEU A 102
ILE A 109
ILE A   4
 None
 0.98A 4y0rA-3i0mA:
undetectable		 4y0rA-3i0mA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A  74
ASN A  89
GLN A  88
 None
 0.83A 5k7uA-3i0mA:
undetectable		 5k7uA-3i0mA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE A  52
GLY A 137
ILE A 138
VAL A 191
ILE A  17
 None
 0.89A 5kr2B-3i0mA:
undetectable		 5kr2B-3i0mA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1
(Schizosaccharomy
ces
pombe) 		5 / 9 ILE A  52
GLY A 137
ILE A 138
VAL A 191
ILE A  17
 None
 0.93A 5kr2D-3i0mA:
undetectable		 5kr2D-3i0mA:
15.43