SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 GLU A  30
ALA A  32
SER A  27
 None
 0.38A 1errB-3i0pA:
undetectable		 1errB-3i0pA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 PHE A  55
ASP A  61
ILE A  60
LEU A 355
 None
 0.95A 1hmyA-3i0pA:
undetectable		 1hmyA-3i0pA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 12 PHE A  55
GLY A  51
ASP A  61
ILE A  60
LEU A 355
 None
 1.03A 2hmyB-3i0pA:
undetectable		 2hmyB-3i0pA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 ALA A 183
GLY A 190
SER A 150
 NAD  A 401 (-3.3A)
None
None
 0.55A 2ivuA-3i0pA:
undetectable		 2ivuA-3i0pA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 ARG A 148
THR A 163
ALA A 147
PRO A 188
 None
NAD  A 401 (-3.9A)
NAD  A 401 ( 4.0A)
NAD  A 401 (-4.1A)
 1.31A 2ql8A-3i0pA:
undetectable
2ql8B-3i0pA:
undetectable		 2ql8A-3i0pA:
16.39
2ql8B-3i0pA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 5 GLN A  53
THR A  49
THR A  38
HIS A  94
 None
 1.43A 3glqA-3i0pA:
undetectable		 3glqA-3i0pA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 5 GLN A  53
THR A  49
THR A  38
HIS A  94
 None
 1.43A 3glqB-3i0pA:
undetectable		 3glqB-3i0pA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 SER A 150
GLY A 162
SER A 185
 None
 0.66A 3loqA-3i0pA:
undetectable		 3loqA-3i0pA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 PHE A 280
GLU A 273
SER A 277
ARG A 148
 None
 1.27A 3nlyA-3i0pA:
1.0
3nlyB-3i0pA:
undetectable		 3nlyA-3i0pA:
21.23
3nlyB-3i0pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 PHE A 280
GLU A 273
SER A 277
ARG A 148
 None
 1.27A 4capA-3i0pA:
0.9
4capB-3i0pA:
undetectable		 4capA-3i0pA:
21.23
4capB-3i0pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 PHE A 280
GLU A 273
SER A 277
ARG A 148
 None
 1.33A 4d32A-3i0pA:
undetectable
4d32B-3i0pA:
undetectable		 4d32A-3i0pA:
21.23
4d32B-3i0pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 6 THR A  38
TYR A 130
HIS A 123
HIS A  50
 None
None
NAD  A 401 (-3.8A)
NAD  A 401 (-3.9A)
 1.34A 4df2A-3i0pA:
undetectable		 4df2A-3i0pA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 GLY A  46
GLY A  51
TYR A  59
LEU A  39
 None
 0.89A 4fgzA-3i0pA:
undetectable		 4fgzA-3i0pA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 GLY A  46
GLY A  51
TYR A  59
LEU A  39
 None
 0.87A 4fgzB-3i0pA:
undetectable		 4fgzB-3i0pA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A   9
SER A  10
THR A  13
 None
GOL  A 402 (-2.9A)
GOL  A 402 (-4.1A)
 0.34A 4luhA-3i0pA:
undetectable		 4luhA-3i0pA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 ILE A  77
VAL A 118
VAL A  85
ARG A  78
 None
 1.34A 4m6tA-3i0pA:
undetectable		 4m6tA-3i0pA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 PHE A 280
GLU A 273
SER A 277
ARG A 148
 None
 1.31A 4v3yA-3i0pA:
undetectable
4v3yB-3i0pA:
undetectable		 4v3yA-3i0pA:
21.23
4v3yB-3i0pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_DIFA601_1
(SERUM ALBUMIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 9 ASP A  28
ASN A  31
ALA A  32
VAL A  35
ARG A  36
 None
 1.33A 4zbrA-3i0pA:
0.0		 4zbrA-3i0pA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_DIFA601_1
(SERUM ALBUMIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 9 LEU A  23
ASP A  28
ASN A  31
ALA A  32
VAL A  35
 None
 1.47A 4zbrA-3i0pA:
0.0		 4zbrA-3i0pA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 9 ASP A  28
ASN A  31
ALA A  32
VAL A  35
ARG A  36
 None
 1.37A 5dbyA-3i0pA:
0.9		 5dbyA-3i0pA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 THR A 145
PRO A 165
ASP A 181
 NAD  A 401 (-4.2A)
NAD  A 401 (-4.1A)
NAD  A 401 (-2.7A)
 0.92A 5l8dB-3i0pA:
undetectable		 5l8dB-3i0pA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 THR A 145
PRO A 165
ASP A 181
 NAD  A 401 (-4.2A)
NAD  A 401 (-4.1A)
NAD  A 401 (-2.7A)
 0.92A 5mwuB-3i0pA:
undetectable		 5mwuB-3i0pA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 SER A 277
ARG A 148
PHE A 280
GLU A 273
 None
 1.26A 5uo7A-3i0pA:
0.9
5uo7B-3i0pA:
1.6		 5uo7A-3i0pA:
21.23
5uo7B-3i0pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 7 ILE A  11
VAL A   9
ILE A  52
THR A 348
 None
 1.00A 6cduF-3i0pA:
undetectable
6cduG-3i0pA:
undetectable		 6cduF-3i0pA:
20.49
6cduG-3i0pA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 8 ILE A  11
VAL A   9
ILE A  52
THR A 348
 None
 0.97A 6cduG-3i0pA:
undetectable
6cduH-3i0pA:
undetectable		 6cduG-3i0pA:
20.49
6cduH-3i0pA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 GLN A  53
THR A  49
THR A  38
HIS A  94
 None
 1.45A 6f3nA-3i0pA:
undetectable		 6f3nA-3i0pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 GLN A  53
THR A  49
THR A  38
HIS A  94
 None
 1.45A 6f3nC-3i0pA:
undetectable		 6f3nC-3i0pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 3i0p MALATE DEHYDROGENASE
(Entamoeba
histolytica) 		4 / 4 GLN A  53
THR A  49
THR A  38
HIS A  94
 None
 1.45A 6f3nD-3i0pA:
undetectable		 6f3nD-3i0pA:
21.64