SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3i0u PHOSPHOTHREONINE
LYASE OSPF
(Shigella
flexneri) 		4 / 5 PHE A  51
TYR A  49
LEU A 169
ASP A 127
 None
 1.25A 1dz6A-3i0uA:
undetectable		 1dz6A-3i0uA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 3i0u PHOSPHOTHREONINE
LYASE OSPF
(Shigella
flexneri) 		4 / 8 ILE A 130
PHE A  51
LEU A 170
VAL A 157
 None
 0.71A 1fslB-3i0uA:
undetectable		 1fslB-3i0uA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3i0u PHOSPHOTHREONINE
LYASE OSPF
(Shigella
flexneri) 		4 / 8 ALA A 151
SER A 106
SER A 209
ALA A 197
 None
 0.60A 4twdF-3i0uA:
undetectable
4twdG-3i0uA:
undetectable
4twdH-3i0uA:
undetectable
4twdI-3i0uA:
undetectable
4twdJ-3i0uA:
undetectable		 4twdF-3i0uA:
21.54
4twdG-3i0uA:
21.54
4twdH-3i0uA:
21.54
4twdI-3i0uA:
21.54
4twdJ-3i0uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3i0u PHOSPHOTHREONINE
LYASE OSPF
(Shigella
flexneri) 		4 / 8 ALA A 151
SER A 106
SER A 209
ALA A 197
 None
 0.75A 4twdF-3i0uA:
undetectable
4twdG-3i0uA:
undetectable
4twdH-3i0uA:
undetectable
4twdI-3i0uA:
undetectable
4twdJ-3i0uA:
undetectable		 4twdF-3i0uA:
21.54
4twdG-3i0uA:
21.54
4twdH-3i0uA:
21.54
4twdI-3i0uA:
21.54
4twdJ-3i0uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3i0u PHOSPHOTHREONINE
LYASE OSPF
(Shigella
flexneri) 		4 / 6 PRO A 192
LEU A 186
GLU A 182
TYR A 207
 None
 1.26A 4z4cA-3i0uA:
undetectable		 4z4cA-3i0uA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3i0u PHOSPHOTHREONINE
LYASE OSPF
(Shigella
flexneri) 		4 / 8 THR A 136
CYH A  64
TYR A  60
TRP A 133
 None
 1.33A 6cnjD-3i0uA:
undetectable
6cnjE-3i0uA:
undetectable		 6cnjD-3i0uA:
16.29
6cnjE-3i0uA:
17.55