SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A 229
PHE A 230
LEU A  98
VAL A 102
VAL A 244
 None
 1.20A 1hrkA-3i0wA:
undetectable		 1hrkA-3i0wA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 4 LEU A  98
SER A 101
TYR A 280
LEU A  92
 None
 1.21A 1xz1A-3i0wA:
undetectable		 1xz1A-3i0wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 4 LEU A  98
SER A 101
TYR A 280
LEU A  92
 None
 1.21A 1xz3A-3i0wA:
undetectable		 1xz3A-3i0wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		5 / 11 ARG A  34
VAL A  54
GLN A  55
GLY A  58
GLU A  59
 None
 1.39A 2h9tH-3i0wA:
undetectable		 2h9tH-3i0wA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A 229
PHE A 230
LEU A  98
VAL A 102
VAL A 244
 None
 1.18A 2hrcB-3i0wA:
undetectable		 2hrcB-3i0wA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 7 GLY A  45
PHE A  79
ILE A  63
PHE A  21
 None
 0.86A 2qmzA-3i0wA:
undetectable
2qmzB-3i0wA:
undetectable		 2qmzA-3i0wA:
21.48
2qmzB-3i0wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 7 ARG A  83
ASN A  20
GLY A 107
VAL A 102
 None
 0.95A 2y05A-3i0wA:
undetectable
2y05B-3i0wA:
undetectable		 2y05A-3i0wA:
21.04
2y05B-3i0wA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 5 VAL A  54
LEU A  23
ILE A  26
VAL A  18
 None
EDO  A 295 (-3.9A)
None
None
 0.87A 4a9kB-3i0wA:
undetectable		 4a9kB-3i0wA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		3 / 3 ASN A 288
LEU A 251
PHE A 282
 None
 0.80A 4dajB-3i0wA:
undetectable		 4dajB-3i0wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 6 PHE A 270
ALA A 277
LEU A 281
VAL A 244
 None
 1.07A 4dubA-3i0wA:
undetectable		 4dubA-3i0wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		5 / 7 GLY A  45
VAL A  51
PHE A  79
ILE A  63
PHE A  21
 None
EDO  A 291 (-4.1A)
None
None
None
 1.15A 4fglC-3i0wA:
undetectable		 4fglC-3i0wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		3 / 3 ARG A 112
ASP A   2
ASP A   4
 None
 0.74A 4kicB-3i0wA:
undetectable		 4kicB-3i0wA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 6 GLY A  45
PHE A  79
ILE A  63
PHE A  21
 None
 1.04A 4qogA-3i0wA:
undetectable
4qogB-3i0wA:
undetectable		 4qogA-3i0wA:
21.75
4qogB-3i0wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		3 / 3 SER A 121
ASP A  80
ASP A 114
 None
None
EDO  A 292 (-4.0A)
 0.80A 4uckA-3i0wA:
undetectable		 4uckA-3i0wA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		3 / 3 ASN A 288
LEU A 251
PHE A 282
 None
 0.66A 5dsgA-3i0wA:
undetectable		 5dsgA-3i0wA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		6 / 12 ALA A 144
GLY A 145
SER A 141
LYS A 143
GLU A 149
LEU A 148
 None
None
None
None
None
EDO  A 291 (-3.6A)
 1.31A 5nwuA-3i0wA:
undetectable		 5nwuA-3i0wA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 6 LEU A  23
PHE A  27
ASP A  28
HIS A  36
 EDO  A 295 (-3.9A)
None
None
None
 1.18A 5om3A-3i0wA:
undetectable
5om3B-3i0wA:
undetectable		 5om3A-3i0wA:
13.79
5om3B-3i0wA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE
(Clostridium
acetobutylicum) 		4 / 5 ALA A 237
TYR A 235
GLN A  31
ILE A 110
 None
 1.46A 6g9bA-3i0wA:
undetectable
6g9bB-3i0wA:
undetectable		 6g9bA-3i0wA:
15.08
6g9bB-3i0wA:
12.81