SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		4 / 5 TYR A 106
GLU A  65
TYR A 128
PRO A 109
 None
UNL  A 143 (-2.1A)
UNL  A 143 ( 4.2A)
None
 1.37A 1mclA-3i0yA:
undetectable
1mclB-3i0yA:
undetectable
1mclP-3i0yA:
undetectable		 1mclA-3i0yA:
23.33
1mclB-3i0yA:
23.33
1mclP-3i0yA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		5 / 12 VAL A  36
LEU A  32
MET A  28
TYR A  16
PHE A  55
 None
None
None
UNL  A 143 (-4.8A)
None
 1.49A 1p5zB-3i0yA:
undetectable		 1p5zB-3i0yA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		5 / 12 THR A 122
ALA A  33
GLU A  34
LEU A  29
LEU A  12
 None
 1.10A 2jfaA-3i0yA:
undetectable		 2jfaA-3i0yA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		4 / 8 TYR A  85
TYR A 128
GLU A  65
ILE A 121
 UNL  A 143 (-4.7A)
UNL  A 143 ( 4.2A)
UNL  A 143 (-2.1A)
None
 0.99A 3jz0B-3i0yA:
undetectable		 3jz0B-3i0yA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		5 / 7 GLU A  34
VAL A  36
GLN A 120
ALA A  30
ARG A  49
 None
 1.34A 3kp6B-3i0yA:
undetectable		 3kp6B-3i0yA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		4 / 8 VAL A  72
VAL A  81
ILE A 121
PHE A 114
 None
 0.50A 3warA-3i0yA:
undetectable		 3warA-3i0yA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		5 / 11 LEU A  32
PHE A  52
ASN A 126
VAL A  72
TYR A  85
 None
None
UNL  A 143 ( 3.3A)
None
UNL  A 143 (-4.7A)
 1.45A 4claA-3i0yA:
undetectable		 4claA-3i0yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		5 / 12 THR A 122
ALA A  33
GLU A  34
LEU A  29
LEU A  12
 None
 1.06A 4xi3A-3i0yA:
undetectable		 4xi3A-3i0yA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		5 / 12 THR A 122
ALA A  33
GLU A  34
LEU A  29
LEU A  12
 None
 1.02A 4xi3D-3i0yA:
undetectable		 4xi3D-3i0yA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3i0y PUTATIVE POLYKETIDE
CYCLASE
(Xanthomonas
campestris) 		4 / 7 VAL A  72
VAL A  81
ILE A 121
PHE A 114
 None
 0.61A 5ywmX-3i0yA:
undetectable		 5ywmX-3i0yA:
18.06