SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 5 ASP A 154
VAL A 230
SER A 229
ASP A 211
 None
 1.25A 1n2xB-3i23A:
6.3		 1n2xB-3i23A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 11 PHE A   7
ILE A  93
THR A  73
VAL A  22
TYR A 305
 None
 1.46A 2gl0B-3i23A:
undetectable
2gl0C-3i23A:
undetectable		 2gl0B-3i23A:
21.49
2gl0C-3i23A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 12 ILE A  93
THR A  73
VAL A  22
TYR A 305
PHE A   7
 None
 1.44A 2gl0A-3i23A:
undetectable
2gl0C-3i23A:
undetectable		 2gl0A-3i23A:
21.49
2gl0C-3i23A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 11 PHE A   7
ILE A  93
THR A  73
VAL A  22
TYR A 305
 None
 1.45A 2gl0E-3i23A:
undetectable
2gl0F-3i23A:
undetectable		 2gl0E-3i23A:
21.49
2gl0F-3i23A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 11 ILE A  93
THR A  73
VAL A  22
TYR A 305
PHE A   7
 None
 1.43A 2gl0D-3i23A:
undetectable
2gl0F-3i23A:
undetectable		 2gl0D-3i23A:
21.49
2gl0F-3i23A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 7 ARG A 182
ASP A 128
ASP A 252
PHE A 237
 None
 1.40A 3kivA-3i23A:
undetectable		 3kivA-3i23A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 10 VAL A  30
PHE A  46
PHE A  53
GLY A  11
ASN A  39
 None
 1.29A 3r6wA-3i23A:
undetectable
3r6wB-3i23A:
3.5		 3r6wA-3i23A:
22.81
3r6wB-3i23A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		3 / 3 TYR A 155
HIS A 228
ARG A 157
 None
 0.92A 4e7bC-3i23A:
3.3		 4e7bC-3i23A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 9 GLY A 299
GLY A 270
PHE A 269
GLY A 129
ASP A 252
 None
 1.46A 4h2gA-3i23A:
undetectable		 4h2gA-3i23A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 6 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 0.97A 4z4cA-3i23A:
4.9		 4z4cA-3i23A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 5 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 1.12A 4z4dA-3i23A:
3.7		 4z4dA-3i23A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 5 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 1.02A 4z4hA-3i23A:
5.0		 4z4hA-3i23A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 7 ILE A  86
VAL A  30
ILE A  66
PHE A   7
 None
 0.77A 5hieC-3i23A:
undetectable		 5hieC-3i23A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 6 ASP A 252
GLY A 299
ASP A 300
ASP A 128
 None
 0.97A 5hp1A-3i23A:
undetectable		 5hp1A-3i23A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 8 ARG A 303
GLY A 129
LEU A 132
THR A 296
 None
 0.90A 5sxqA-3i23A:
undetectable		 5sxqA-3i23A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 8 ARG A 303
GLY A 129
LEU A 132
THR A 296
 None
 0.83A 5sxtA-3i23A:
undetectable		 5sxtA-3i23A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 8 ARG A 303
GLY A 129
LEU A 132
THR A 296
 None
 0.86A 5sxtB-3i23A:
undetectable		 5sxtB-3i23A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 8 ARG A 303
GLY A 129
LEU A 132
THR A 296
 None
 0.87A 5syjB-3i23A:
undetectable		 5syjB-3i23A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 5 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 1.20A 5weaA-3i23A:
4.3		 5weaA-3i23A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 5 GLY A 315
THR A 311
ASN A 314
LYS A 313
 None
 0.90A 5x23A-3i23A:
undetectable		 5x23A-3i23A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 6 GLY A 315
THR A 311
ASN A 314
LYS A 313
 None
 0.88A 5x24A-3i23A:
undetectable		 5x24A-3i23A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 6 GLY A 315
THR A 311
ASN A 314
LYS A 313
 None
 1.02A 5xxiA-3i23A:
undetectable		 5xxiA-3i23A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 5 TYR A 309
LYS A 313
LEU A  68
GLU A  67
 None
 1.17A 6cbdA-3i23A:
4.9		 6cbdA-3i23A:
18.76