SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		4 / 8 ASP A  94
SER A 105
TYR A  53
HIS A  49
 None
None
None
NI  A 146 (-3.1A)
 1.35A 2bteD-3i2bA:
undetectable		 2bteD-3i2bA:
9.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		7 / 10 HIS A  24
HIS A  49
HIS A  51
THR A 106
THR A 107
GLU A 108
GLU A 134
 NI  A 146 (-3.1A)
NI  A 146 (-3.1A)
NI  A 146 (-3.3A)
None
None
None
NI  A 146 (-3.8A)
 0.57A 2dttA-3i2bA:
16.2
2dttC-3i2bA:
16.1		 2dttA-3i2bA:
30.71
2dttC-3i2bA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_B_H4BB1001_1
(HYPOTHETICAL PROTEIN
PH0634)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		5 / 10 HIS A  49
THR A 106
THR A 107
GLU A 108
GLU A 134
 NI  A 146 (-3.1A)
None
None
None
NI  A 146 (-3.8A)
 0.65A 2dttA-3i2bA:
16.2
2dttB-3i2bA:
15.6		 2dttA-3i2bA:
30.71
2dttB-3i2bA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		7 / 10 HIS A  24
HIS A  49
HIS A  51
THR A 106
THR A 107
GLU A 108
GLU A 134
 NI  A 146 (-3.1A)
NI  A 146 (-3.1A)
NI  A 146 (-3.3A)
None
None
None
NI  A 146 (-3.8A)
 0.72A 2dttD-3i2bA:
16.2
2dttF-3i2bA:
16.1		 2dttD-3i2bA:
30.71
2dttF-3i2bA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		7 / 11 HIS A  24
HIS A  49
HIS A  51
THR A 106
THR A 107
GLU A 108
GLU A 134
 NI  A 146 (-3.1A)
NI  A 146 (-3.1A)
NI  A 146 (-3.3A)
None
None
None
NI  A 146 (-3.8A)
 0.71A 2dttD-3i2bA:
16.2
2dttE-3i2bA:
15.6		 2dttD-3i2bA:
30.71
2dttE-3i2bA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		5 / 9 HIS A  51
THR A 106
THR A 107
GLU A 108
GLU A 134
 NI  A 146 (-3.3A)
None
None
None
NI  A 146 (-3.8A)
 0.48A 2dttE-3i2bA:
15.6
2dttF-3i2bA:
16.1		 2dttE-3i2bA:
30.71
2dttF-3i2bA:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		4 / 8 ASP A  94
SER A 105
TYR A  53
HIS A  49
 None
None
None
NI  A 146 (-3.1A)
 1.21A 2v0gA-3i2bA:
undetectable		 2v0gA-3i2bA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.67A 5qglA-3i2bA:
undetectable		 5qglA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.67A 5qguA-3i2bA:
undetectable		 5qguA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.67A 5qgvA-3i2bA:
undetectable		 5qgvA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.65A 5qgwA-3i2bA:
undetectable		 5qgwA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.66A 5qgxA-3i2bA:
undetectable		 5qgxA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.67A 5qgyA-3i2bA:
undetectable		 5qgyA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.65A 5qgzA-3i2bA:
undetectable		 5qgzA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.65A 5qh0A-3i2bA:
undetectable		 5qh0A-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.68A 5qh1A-3i2bA:
undetectable		 5qh1A-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.65A 5qh2A-3i2bA:
undetectable		 5qh2A-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.67A 5qh3A-3i2bA:
undetectable		 5qh3A-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.69A 5qh4A-3i2bA:
undetectable		 5qh4A-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.68A 5qh9A-3i2bA:
undetectable		 5qh9A-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.61A 5qhaA-3i2bA:
undetectable		 5qhaA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.68A 5qhcA-3i2bA:
undetectable		 5qhcA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.69A 5qheA-3i2bA:
undetectable		 5qheA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.67A 5qhfA-3i2bA:
undetectable		 5qhfA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 130
GLN A 119
 None
 0.67A 5qhhA-3i2bA:
undetectable		 5qhhA-3i2bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 HIS A  24
HIS A  51
HIS A  49
 NI  A 146 (-3.1A)
NI  A 146 (-3.3A)
NI  A 146 (-3.1A)
 0.61A 5zrdA-3i2bA:
undetectable		 5zrdA-3i2bA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Homo
sapiens) 		3 / 3 HIS A  49
HIS A  24
HIS A  51
 NI  A 146 (-3.1A)
NI  A 146 (-3.1A)
NI  A 146 (-3.3A)
 0.53A 5zrdA-3i2bA:
undetectable		 5zrdA-3i2bA:
14.63