SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 318
LEU A 320
GLU A 317
LEU A 386
 None
 0.79A 3h5gA-3i2dA:
undetectable
3h5gC-3i2dA:
undetectable		 3h5gA-3i2dA:
6.79
3h5gC-3i2dA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 228
ALA A 278
ILE A 189
ILE A 261
VAL A 293
 None
 1.04A 4nkxA-3i2dA:
undetectable		 4nkxA-3i2dA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 228
ALA A 278
ILE A 189
ILE A 261
VAL A 293
 None
 1.02A 4nkxC-3i2dA:
undetectable		 4nkxC-3i2dA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 228
ALA A 278
ILE A 189
ILE A 261
VAL A 293
 None
 1.02A 4nkxD-3i2dA:
undetectable		 4nkxD-3i2dA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 367
LEU A 412
ILE A 414
PHE A 383
 None
 0.87A 4v04A-3i2dA:
undetectable		 4v04A-3i2dA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 214
ASN A 217
LEU A 218
 None
 0.51A 5i1oA-3i2dA:
undetectable		 5i1oA-3i2dA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		5 / 9 ASN A 291
ASP A 215
ILE A 310
GLY A 308
PRO A 282
 None
 1.11A 5kr2A-3i2dA:
undetectable		 5kr2A-3i2dA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 215
ILE A 310
GLY A 308
THR A 281
PRO A 282
 None
 1.26A 5kr2A-3i2dA:
undetectable		 5kr2A-3i2dA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3i2d E3 SUMO-PROTEIN
LIGASE SIZ1
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 205
MET A 194
ASN A 195
 None
 0.94A 5qh8A-3i2dA:
undetectable		 5qh8A-3i2dA:
18.13