SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		5 / 12 VAL X 191
TRP X 271
VAL X 202
LEU X 168
LEU X 269
 None
 1.13A 1s19A-3i2mX:
undetectable		 1s19A-3i2mX:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		5 / 8 LEU X  98
PHE X  99
ARG X  61
THR X  45
LEU X  66
 None
 1.43A 1v55N-3i2mX:
undetectable
1v55W-3i2mX:
undetectable		 1v55N-3i2mX:
20.62
1v55W-3i2mX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		5 / 8 LEU X  98
PHE X  99
ARG X  61
THR X  45
LEU X  66
 None
 1.36A 3abkA-3i2mX:
undetectable
3abkJ-3i2mX:
undetectable		 3abkA-3i2mX:
20.62
3abkJ-3i2mX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		5 / 8 LEU X  98
PHE X  99
ARG X  61
THR X  45
LEU X  66
 None
 1.42A 3asoN-3i2mX:
undetectable
3asoW-3i2mX:
undetectable		 3asoN-3i2mX:
20.62
3asoW-3i2mX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		3 / 3 ARG X  21
VAL X  48
THR X  30
 None
 0.84A 3k4vA-3i2mX:
undetectable		 3k4vA-3i2mX:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		3 / 3 ARG X  21
VAL X  48
THR X  30
 None
 0.83A 3nduD-3i2mX:
undetectable		 3nduD-3i2mX:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		4 / 6 THR X  95
SER X  82
ILE X 150
THR X  93
 None
 1.12A 3q70A-3i2mX:
undetectable		 3q70A-3i2mX:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		3 / 3 ARG X  21
VAL X  48
THR X  30
 None
 0.85A 3tl9A-3i2mX:
undetectable		 3tl9A-3i2mX:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		5 / 12 ALA X 255
GLY X  53
GLY X  56
ALA X 254
GLU X 187
 None
 0.94A 4lg1B-3i2mX:
undetectable		 4lg1B-3i2mX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		3 / 3 PRO X  68
VAL X  37
HIS X  38
 None
 0.81A 4pevC-3i2mX:
undetectable		 4pevC-3i2mX:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		6 / 12 LEU X 252
LEU X 256
ILE X 253
LYS X 186
VAL X 295
LEU X 297
 None
 1.47A 4y0sA-3i2mX:
undetectable		 4y0sA-3i2mX:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		4 / 6 LEU X  98
PHE X  99
ARG X  61
THR X  45
 None
 0.97A 5b1aN-3i2mX:
undetectable
5b1aW-3i2mX:
undetectable		 5b1aN-3i2mX:
20.62
5b1aW-3i2mX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		5 / 12 ILE X  19
VAL X  48
LEU X  15
PHE X  99
THR X  95
 None
 1.27A 5bykA-3i2mX:
undetectable		 5bykA-3i2mX:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		5 / 8 LEU X  98
PHE X  99
ARG X  61
THR X  45
LEU X  66
 None
 1.41A 5zcpN-3i2mX:
undetectable
5zcpW-3i2mX:
undetectable		 5zcpN-3i2mX:
20.62
5zcpW-3i2mX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		4 / 5 GLN X  36
VAL X  37
PRO X 152
THR X  43
 None
 1.12A 6cduA-3i2mX:
undetectable
6cduB-3i2mX:
undetectable		 6cduA-3i2mX:
25.47
6cduB-3i2mX:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3i2m ORF59
(Human
gammaherpesvirus
8) 		3 / 3 LEU X  16
GLY X 100
PHE X  92
 None
 0.62A 6exiC-3i2mX:
undetectable		 6exiC-3i2mX:
15.73