SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		4 / 8 TYR A 289
ASP A 240
VAL A 238
GLY A 309
 None
 0.97A 1ekjA-3i2nA:
undetectable
1ekjB-3i2nA:
undetectable		 1ekjA-3i2nA:
19.89
1ekjB-3i2nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		4 / 6 TYR A 289
ASP A 240
VAL A 238
GLY A 309
 None
 0.99A 1ekjC-3i2nA:
undetectable
1ekjD-3i2nA:
undetectable		 1ekjC-3i2nA:
19.89
1ekjD-3i2nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		4 / 6 ASP A 240
VAL A 238
GLY A 309
TYR A 289
 None
 1.06A 1ekjC-3i2nA:
undetectable
1ekjD-3i2nA:
undetectable		 1ekjC-3i2nA:
19.89
1ekjD-3i2nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		4 / 6 SER A 231
VAL A 212
GLY A 211
GLU A 205
 None
 0.95A 1fduD-3i2nA:
undetectable		 1fduD-3i2nA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		5 / 12 VAL A 170
ASP A 118
ASP A 166
ARG A 266
GLY A  71
 None
 1.39A 1ia0B-3i2nA:
undetectable		 1ia0B-3i2nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		5 / 12 VAL A 170
ASP A 118
ASP A 166
ARG A 266
GLY A  71
 None
 1.39A 1tubB-3i2nA:
undetectable		 1tubB-3i2nA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		3 / 3 SER A 214
ASP A 328
CYH A 337
 None
 0.98A 2br4E-3i2nA:
undetectable		 2br4E-3i2nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		3 / 3 GLN A 264
THR A 261
TRP A 168
 None
 1.03A 2rctA-3i2nA:
undetectable		 2rctA-3i2nA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		4 / 7 LEU A 202
PHE A 195
TYR A 187
PRO A 158
 None
 0.98A 2vq5B-3i2nA:
undetectable		 2vq5B-3i2nA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		3 / 3 ASP A  23
ARG A 266
LYS A  25
 None
 1.15A 3wipG-3i2nA:
undetectable		 3wipG-3i2nA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		3 / 3 ASN A 189
ASP A 191
ASN A 207
 None
 0.52A 4agaA-3i2nA:
undetectable		 4agaA-3i2nA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		3 / 3 HIS A 267
GLU A 273
ASN A 225
 None
 1.04A 4bupB-3i2nA:
undetectable		 4bupB-3i2nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		3 / 3 ASP A 218
ARG A 272
ASP A 240
 None
 0.87A 4fp9D-3i2nA:
undetectable		 4fp9D-3i2nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		3 / 3 ASP A 218
ARG A 272
ASP A 240
 None
 0.87A 4fzvA-3i2nA:
undetectable		 4fzvA-3i2nA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		5 / 12 TYR A 105
LEU A  97
THR A  85
GLY A  71
GLY A 109
 None
 1.07A 5d4uA-3i2nA:
undetectable		 5d4uA-3i2nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		5 / 12 TYR A 105
LEU A  97
THR A  85
GLY A  71
GLY A 109
 None
 1.09A 5d4uB-3i2nA:
undetectable		 5d4uB-3i2nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		5 / 9 ASP A 191
GLY A 186
LEU A 215
LEU A 227
ALA A 229
 None
 1.09A 5dqfA-3i2nA:
undetectable		 5dqfA-3i2nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		4 / 5 GLU A 205
THR A 206
HIS A 237
LEU A 215
 None
 1.14A 5utuH-3i2nA:
undetectable		 5utuH-3i2nA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3i2n WD REPEAT-CONTAINING
PROTEIN 92
(Homo
sapiens) 		3 / 3 LYS A  25
SER A 340
SER A 326
 None
 1.15A 6gbfA-3i2nA:
undetectable		 6gbfA-3i2nA:
23.14