SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 ALA A 405
VAL A 430
TRP A 457
 None
 0.88A 1av2A-3i2tA:
undetectable
1av2B-3i2tA:
undetectable		 1av2A-3i2tA:
3.28
1av2B-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 ALA A 405
VAL A 430
TRP A 457
 None
 0.93A 1c4dC-3i2tA:
undetectable
1c4dD-3i2tA:
undetectable		 1c4dC-3i2tA:
3.28
1c4dD-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 TRP A 457
ALA A 405
VAL A 430
 None
 0.87A 1c4dC-3i2tA:
undetectable
1c4dD-3i2tA:
undetectable		 1c4dC-3i2tA:
3.28
1c4dD-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 8 PHE A 387
PHE A 381
THR A 334
LEU A 310
 None
 1.18A 1ea1A-3i2tA:
undetectable		 1ea1A-3i2tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 7 ARG A 329
ILE A 328
LEU A 390
PHE A 362
 None
 0.85A 1rtsB-3i2tA:
undetectable		 1rtsB-3i2tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 ALA A 405
VAL A 430
TRP A 457
 None
 0.88A 1w5uA-3i2tA:
undetectable
1w5uB-3i2tA:
undetectable		 1w5uA-3i2tA:
3.28
1w5uB-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 TRP A 457
ALA A 405
VAL A 430
 None
 0.91A 1w5uA-3i2tA:
undetectable
1w5uB-3i2tA:
undetectable		 1w5uA-3i2tA:
3.28
1w5uB-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 MET A 418
LEU A 406
ASN A 373
ILE A 330
SER A 412
 None
 1.31A 1xlxA-3i2tA:
undetectable		 1xlxA-3i2tA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 MET A 418
LEU A 406
ASN A 373
ILE A 330
SER A 412
 None
 1.43A 1xotB-3i2tA:
undetectable		 1xotB-3i2tA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 6 TRP A  41
LEU A  39
LEU A  42
PRO A  13
 None
 1.19A 2dqyC-3i2tA:
undetectable		 2dqyC-3i2tA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 4 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.83A 2hrcA-3i2tA:
undetectable		 2hrcA-3i2tA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 4 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.74A 2hrcB-3i2tA:
undetectable		 2hrcB-3i2tA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 TRP A 457
ALA A 405
VAL A 430
 None
 0.89A 2izqC-3i2tA:
undetectable
2izqD-3i2tA:
undetectable		 2izqC-3i2tA:
3.28
2izqD-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 LEU A  42
PRO A  43
LEU A  47
 None
 0.56A 2po7B-3i2tA:
undetectable		 2po7B-3i2tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 4 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.99A 2qd2A-3i2tA:
undetectable		 2qd2A-3i2tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 SER A 141
GLU A  57
ASP A  34
 None
 0.78A 2zulA-3i2tA:
undetectable		 2zulA-3i2tA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 8 GLY A   5
GLY A  35
GLY A  60
ILE A  80
 None
 0.70A 3d41A-3i2tA:
undetectable		 3d41A-3i2tA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 SER A 141
GLU A  57
ASP A  34
 None
 0.75A 3dmhA-3i2tA:
undetectable		 3dmhA-3i2tA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 LEU A  42
LEU A  47
ARG A  24
 None
 0.59A 3hcnB-3i2tA:
undetectable		 3hcnB-3i2tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 4 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.88A 3hcoA-3i2tA:
undetectable		 3hcoA-3i2tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 4 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.73A 3hcoB-3i2tA:
undetectable		 3hcoB-3i2tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 LEU A  42
PRO A  43
LEU A  47
 None
 0.45A 3hcrA-3i2tA:
undetectable		 3hcrA-3i2tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ALA A 405
LEU A 421
LYS A 422
ILE A 443
LEU A 492
 None
 1.41A 3ia4A-3i2tA:
undetectable		 3ia4A-3i2tA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 7 LEU A  49
VAL A 115
ILE A 109
ARG A  83
 None
 1.31A 3ik3A-3i2tA:
undetectable		 3ik3A-3i2tA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 8 GLU A 417
TYR A 386
SER A 411
ILE A 408
 NAG  A3830 ( 4.8A)
NAG  A3830 (-4.9A)
None
None
 1.09A 3jz0B-3i2tA:
undetectable		 3jz0B-3i2tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 LEU A 416
ILE A 408
LEU A 437
ASP A 436
PHE A 381
 None
None
None
NDG  A4701 ( 3.1A)
None
 1.18A 3ko0A-3i2tA:
undetectable
3ko0B-3i2tA:
undetectable
3ko0C-3i2tA:
undetectable
3ko0D-3i2tA:
undetectable		 3ko0A-3i2tA:
11.34
3ko0B-3i2tA:
11.34
3ko0C-3i2tA:
11.34
3ko0D-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 PHE A 381
LEU A 416
ILE A 408
LEU A 437
ASP A 436
 None
None
None
None
NDG  A4701 ( 3.1A)
 1.18A 3ko0G-3i2tA:
undetectable
3ko0H-3i2tA:
undetectable
3ko0I-3i2tA:
undetectable
3ko0J-3i2tA:
undetectable		 3ko0G-3i2tA:
11.34
3ko0H-3i2tA:
11.34
3ko0I-3i2tA:
11.34
3ko0J-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 11 PHE A 381
LEU A 437
ASP A 436
LEU A 416
ILE A 408
 None
None
NDG  A4701 ( 3.1A)
None
None
 1.19A 3ko0A-3i2tA:
undetectable
3ko0B-3i2tA:
undetectable
3ko0I-3i2tA:
undetectable
3ko0J-3i2tA:
undetectable		 3ko0A-3i2tA:
11.34
3ko0B-3i2tA:
11.34
3ko0I-3i2tA:
11.34
3ko0J-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 LEU A 416
ILE A 408
LEU A 437
ASP A 436
PHE A 381
 None
None
None
NDG  A4701 ( 3.1A)
None
 1.11A 3ko0K-3i2tA:
undetectable
3ko0L-3i2tA:
undetectable
3ko0S-3i2tA:
undetectable
3ko0T-3i2tA:
undetectable		 3ko0K-3i2tA:
11.34
3ko0L-3i2tA:
11.34
3ko0S-3i2tA:
11.34
3ko0T-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 LEU A 437
ASP A 436
LEU A 416
ILE A 408
PHE A 381
 None
NDG  A4701 ( 3.1A)
None
None
None
 1.20A 3ko0K-3i2tA:
undetectable
3ko0L-3i2tA:
undetectable
3ko0M-3i2tA:
undetectable
3ko0N-3i2tA:
undetectable		 3ko0K-3i2tA:
11.34
3ko0L-3i2tA:
11.34
3ko0M-3i2tA:
11.34
3ko0N-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 LEU A 416
ILE A 408
LEU A 437
ASP A 436
PHE A 381
 None
None
None
NDG  A4701 ( 3.1A)
None
 1.14A 3ko0M-3i2tA:
undetectable
3ko0N-3i2tA:
undetectable
3ko0O-3i2tA:
undetectable
3ko0P-3i2tA:
undetectable		 3ko0M-3i2tA:
11.34
3ko0N-3i2tA:
11.34
3ko0O-3i2tA:
11.34
3ko0P-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 PHE A 381
LEU A 437
ASP A 436
LEU A 416
ILE A 408
 None
None
NDG  A4701 ( 3.1A)
None
None
 1.12A 3ko0M-3i2tA:
undetectable
3ko0N-3i2tA:
undetectable
3ko0O-3i2tA:
undetectable
3ko0P-3i2tA:
undetectable		 3ko0M-3i2tA:
11.34
3ko0N-3i2tA:
11.34
3ko0O-3i2tA:
11.34
3ko0P-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		3 / 3 TRP A 457
ALA A 405
VAL A 430
 None
 0.91A 3l8lC-3i2tA:
undetectable
3l8lD-3i2tA:
undetectable		 3l8lC-3i2tA:
3.28
3l8lD-3i2tA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		6 / 12 VAL A  33
PHE A  74
ILE A  80
LEU A  97
PHE A  86
VAL A  99
 None
 1.39A 3w68A-3i2tA:
undetectable		 3w68A-3i2tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		6 / 12 VAL A  33
PHE A  74
ILE A  80
LEU A  97
PHE A  86
VAL A  99
 None
 1.45A 3w68D-3i2tA:
undetectable		 3w68D-3i2tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE A 109
GLY A 121
VAL A 115
ILE A 139
VAL A 140
 None
 0.83A 4c9lA-3i2tA:
undetectable		 4c9lA-3i2tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE A 109
GLY A 121
VAL A 115
ILE A 139
VAL A 140
 None
 0.80A 4c9lB-3i2tA:
undetectable		 4c9lB-3i2tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE A 109
GLY A 121
VAL A 115
ILE A 139
VAL A 140
 None
 0.86A 4c9oA-3i2tA:
undetectable		 4c9oA-3i2tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 ILE A 109
GLY A 121
VAL A 115
ILE A 139
VAL A 140
 None
 0.87A 4c9oB-3i2tA:
undetectable		 4c9oB-3i2tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 10 VAL A 429
TRP A 445
ILE A 448
LEU A 384
LEU A 416
 None
 1.22A 4jtqA-3i2tA:
undetectable		 4jtqA-3i2tA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 5 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.92A 4klrA-3i2tA:
undetectable		 4klrA-3i2tA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 5 ARG A  83
THR A  59
ASP A  34
TYR A 259
 None
 1.50A 4qwpA-3i2tA:
undetectable		 4qwpA-3i2tA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 5 ARG A  83
THR A  59
ASP A  34
TYR A 259
 None
 1.46A 4qwpB-3i2tA:
undetectable		 4qwpB-3i2tA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 7 VAL A 429
TRP A 445
ILE A 448
LEU A 384
 None
 1.00A 4xo7B-3i2tA:
undetectable		 4xo7B-3i2tA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		5 / 12 LEU A 359
VAL A 361
PHE A 362
VAL A 307
GLY A 313
 None
 1.44A 5i8fA-3i2tA:
undetectable		 5i8fA-3i2tA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		6 / 12 VAL A  33
PHE A  74
ILE A  80
LEU A  97
PHE A  86
VAL A  99
 None
 1.44A 5mueA-3i2tA:
undetectable		 5mueA-3i2tA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 5 ARG A 157
MET A 104
THR A 106
LEU A 107
 None
 1.32A 5x1bW-3i2tA:
undetectable		 5x1bW-3i2tA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A
(Drosophila
melanogaster) 		4 / 5 ARG A 157
MET A 104
THR A 106
LEU A 107
 None
 1.38A 6nknJ-3i2tA:
undetectable		 6nknJ-3i2tA:
7.01