SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3
(Homo
sapiens) 		3 / 3 GLN A  25
HIS A  38
PRO A  24
 None
 0.96A 1d8cA-3i2vA:
undetectable		 1d8cA-3i2vA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3
(Homo
sapiens) 		4 / 6 ALA A  58
ILE A  74
VAL A  72
PHE A  16
 None
 0.95A 2cizA-3i2vA:
undetectable		 2cizA-3i2vA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3
(Homo
sapiens) 		5 / 10 VAL A  76
ASP A  21
LEU A  44
LEU A  41
ALA A  87
 None
 0.96A 2v3kA-3i2vA:
undetectable		 2v3kA-3i2vA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3
(Homo
sapiens) 		4 / 5 ALA A  87
GLY A  81
CYH A  78
LYS A  79
 None
 1.49A 2ylgA-3i2vA:
undetectable		 2ylgA-3i2vA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3
(Homo
sapiens) 		3 / 3 LEU A  33
ARG A  32
ARG A  23
 None
 0.86A 4yiaB-3i2vA:
undetectable		 4yiaB-3i2vA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3
(Homo
sapiens) 		5 / 12 HIS A  17
ILE A  74
VAL A 108
VAL A   2
LEU A  91
 None
 1.02A 5bykA-3i2vA:
undetectable		 5bykA-3i2vA:
19.77