SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 12 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
1.03A 1eqhA-3i32A:
undetectable
1eqhA-3i32A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 12 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
1.04A 1eqhB-3i32A:
undetectable
1eqhB-3i32A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 11 LEU A 341
VAL A 218
GLU A 227
LEU A 258
LEU A 233
None
1.33A 1mrqA-3i32A:
undetectable
1mrqA-3i32A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
3 / 3 ARG A 444
ARG A 449
PRO A 443
None
1.12A 2wljA-3i32A:
undetectable
2wljA-3i32A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 12 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
1.02A 3n8wA-3i32A:
undetectable
3n8wA-3i32A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 12 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
1.04A 3n8zA-3i32A:
undetectable
3n8zA-3i32A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 12 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
0.94A 3pghC-3i32A:
undetectable
3pghC-3i32A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 12 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
1.00A 3rr3A-3i32A:
undetectable
3rr3A-3i32A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 12 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
0.99A 3rr3B-3i32A:
undetectable
3rr3B-3i32A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
4 / 5 LEU A 233
ARG A 290
PRO A 264
ALA A 265
None
1.33A 3vm4A-3i32A:
undetectable
3vm4A-3i32A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 12 PHE A 284
LEU A 258
VAL A 243
GLY A 336
THR A 329
None
1.32A 4mubA-3i32A:
undetectable
4mubA-3i32A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 10 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
0.95A 4ph9A-3i32A:
undetectable
4ph9A-3i32A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 10 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
None
0.93A 4ph9B-3i32A:
undetectable
4ph9B-3i32A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 11 PRO A 481
LEU A 454
VAL A 464
TYR A 438
GLY A 462
None
1.45A 5hbmA-3i32A:
undetectable
5hbmA-3i32A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
3 / 3 VAL A 235
GLU A 214
GLU A 216
None
0.77A 5jsdB-3i32A:
undetectable
5jsdC-3i32A:
undetectable
5jsdB-3i32A:
17.03
5jsdC-3i32A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
5 / 10 PRO A 367
LEU A 232
VAL A 372
SER A 230
GLU A 227
None
1.43A 5tixB-3i32A:
undetectable
5tixB-3i32A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus)
4 / 6 LEU A 341
TYR A 313
VAL A 289
GLY A 224
None
0.99A 6hd4B-3i32A:
undetectable
6hd4B-3i32A:
16.10